Search Results - "Vanderluit, Jacqueline L."

Rapid degeneration of neurons in the penumbra region following a small, focal ischemic stroke by Fifield, Kathleen E., Vanderluit, Jacqueline L.

“…Ischemic stroke causes immediate cell death within the infarct core, whereas cells in the surrounding penumbra region are damaged but can be salvaged. Rapid…”
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A pref-1-controlled non-inflammatory mechanism of insulin resistance by Huang, Yiheng, Cui, Donghong, Chen, Liujun, Tong, Haibin, Wu, Hong, Muller, Grace K., Qi, Yadan, Wang, Shuxia, Xu, Jinjie, Gao, Xiang, Fifield, Kathleen E., Wang, Lingyan, Xia, Zhengyuan, Vanderluit, Jacqueline L., Liu, Suixin, Leng, Lin, Sun, Guang, McGuire, John, Young, Lawrence H., Bucala, Richard, Qi, Dake

“…While insulin resistance (IR) is associated with inflammation in white adipose tissue, we report a non-inflammatory adipose mechanism of high fat-induced IR…”
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Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms by Cheung, Eric C. C, Melanson-Drapeau, Lysanne, Cregan, Sean P, Vanderluit, Jacqueline L, Ferguson, Kerry L, McIntosh, William C, Park, David S, Bennett, Steffany A. L, Slack, Ruth S

“…Mitochondria release proteins that propagate both caspase-dependent and caspase-independent cell death pathways. AIF (apoptosis-inducing factor) is an…”
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The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis by Flemmer, Robert T, Connolly, Sarah P, Geizer, Brittany A, Opferman, Joseph T, Vanderluit, Jacqueline L

“…Myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic Bcl-2 protein, regulates neural precursor cell (NPC) survival in both the developing and adult mammalian…”
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Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions by McClellan, Kelly A., Ruzhynsky, Vladimir A., Douda, David N., Vanderluit, Jacqueline L., Ferguson, Kerry L., Chen, Danian, Bremner, Rod, Park, David S., Leone, Gustavo, Slack, Ruth S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mcl-1 and Bcl-xL are essential for survival of the developing nervous system by Fogarty, Lauren C., Flemmer, Robert T., Geizer, Brittany A., Licursi, Maria, Karunanithy, Ahila, Opferman, Joseph T., Hirasawa, Kensuke, Vanderluit, Jacqueline L.

“…During neurogenesis, proliferating neural precursor cells (NPC) exit the cell cycle and differentiate into postmitotic neurons. The proteins that regulate cell…”
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The p107/E2F Pathway Regulates Fibroblast Growth Factor 2 Responsiveness in Neural Precursor Cells by McClellan, Kelly A., Vanderluit, Jacqueline L., Julian, Lisa M., Andrusiak, Matthew G., Dugal-Tessier, Delphie, Park, David S., Slack, Ruth S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke by Fifield, Kathleen E., Rowe, Todd M., Raman-Nair, Joanna B., Hirasawa, Michiru, Vanderluit, Jacqueline L.

“…Obesity is associated with worse neurological outcomes following overt ischemic strokes. The majority of strokes however, are covert, small strokes that often…”
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MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner by Germain, Marc, Nguyen, Angela P, Le Grand, J Nicole, Arbour, Nicole, Vanderluit, Jacqueline L, Park, David S, Opferman, Joseph T, Slack, Ruth S

“…Apoptosis has an important role during development to regulate cell number. In differentiated cells, however, activation of autophagy has a critical role by…”
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Paw-dragging: a novel, sensitive analysis of the mouse cylinder test by Roome, R Brian, Vanderluit, Jacqueline L

“…The cylinder test is routinely used to predict focal ischemic damage to the forelimb motor cortex in rodents. When placed in the cylinder, rodents explore by…”
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Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons by McPhail, Lowell T., Fernandes, Karl J.L., Chan, Carmen C.M., Vanderluit, Jacqueline L., Tetzlaff, Wolfram

“…Recently, we reported that chronically axotomized rubrospinal neurons survive for up to 1 year in an atrophied state. This finding contrasted previous work…”
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c-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo through Mechanisms Independent of c-Jun Phosphorylation by Keramaris, Elizabeth, Vanderluit, Jacqueline L., Bahadori, Mohammad, Mousavi, Kambiz, Davis, Roger J., Flavell, Richard, Slack, Ruth S., Park, David S.

“…Both the transcription factor c-Jun and the c-Jun N-terminal kinases (JNKs) have been associated with neuronal loss in several death paradigms. JNK are key…”
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A reproducible Endothelin-1 model of forelimb motor cortex stroke in the mouse by Roome, R. Brian, Bartlett, Robert F., Jeffers, Matthew, Xiong, Jieying, Corbett, Dale, Vanderluit, Jacqueline L.

“…•Intra-cortical injections of Endothelin-1 generate a reproducible ischemic injury.•Infarcts targeted to the anterior FMC result in consistent behavioral…”
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A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration by Ferguson, Kerry L, McClellan, Kelly A, Vanderluit, Jacqueline L, McIntosh, William C, Schuurmans, Carol, Polleux, Franck, Slack, Ruth S

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Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage by Arbour, Nicole, Vanderluit, Jacqueline L, Le Grand, J. Nicole, Jahani-Asl, Arezu, Ruzhynsky, Vladimir A, Cheung, Eric C. C, Kelly, Melissa A, MacKenzie, Alexander E, Park, David S, Opferman, Joseph T, Slack, Ruth S

“…Despite the importance of Mcl-1, an anti-apoptotic Bcl-2 family member, in the regulation of apoptosis, little is known regarding its role in nervous system…”
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Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord by Fogarty, Lauren C., Song, Beibei, Suppiah, Yegappan, Hasan, S.M. Mahmud, Martin, Hiliary C., Hogan, Sarah E., Xiong, Jieying, Vanderluit, Jacqueline L.

“…The bcl-2 family of survival and death promoting proteins play a key role in regulating cell numbers during nervous system development. Bcl-xL, an…”
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Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents by Vanderluit, Jacqueline L., McPhail, Lowell T., Fernandes, Karl J. L., McBride, Christopher B., Huguenot, Claire, Roy, Sophie, Robertson, George S., Nicholson, Donald W., Tetzlaff, Wolfram

“…In this report, we examined the possible functions of the cell death protease, caspase‐3, in the axotomy‐induced apoptosis of facial motoneurons in newborn…”
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Mcl-1 regulates the survival of adult neural precursor cells by Malone, Craig D., Hasan, S.M. Mahmudul, Roome, R. Brian, Xiong, Jieying, Furlong, Michael, Opferman, Joseph T., Vanderluit, Jacqueline L.

“…Since the discovery of neural precursor cells (NPCs) in the adult mammalian brain, there has been a lot of excitement surrounding the potential for…”
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Caspase inhibition attenuates transection-induced oligodendrocyte apoptosis in the developing chick spinal cord by McBride, Christopher B., McPhail, Lowell T., Vanderluit, Jacqueline L., Tetzlaff, Wolfram, Steeves, John D.

“…A developmental model of spinal cord injury in the embryonic chick was specifically developed to characterize the involvement of caspases in injury-induced…”
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Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1 by Hasan, S M Mahmudul, Sheen, Ashley D, Power, Angela M, Langevin, Lisa Marie, Xiong, Jieying, Furlong, Michael, Day, Kristine, Schuurmans, Carol, Opferman, Joseph T, Vanderluit, Jacqueline L

“…Cortical development requires the precise timing of neural precursor cell (NPC) terminal mitosis. Although cell cycle proteins regulate terminal mitosis, the…”
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