Search Results - "Vanderlugt, Carol L"

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis by Vanderlugt, Carol L, Neville, Katherine L, Nikcevich, Kelly M, Eagar, Todd N, Bluestone, Jeffrey A, Miller, Stephen D

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) is a CD4+ T cell-mediated demyelinating disease model for multiple sclerosis. Myelin destruction…”
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Epitope spreading in immune-mediated diseases: implications for immunotherapy by Miller, Stephen D, Vanderlugt, Carol L

“…Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B…”
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Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading by Miller, Stephen D, Vanderlugt, Carol L, Begolka, Wendy Smith, Pao, Winnie, Yauch, Robert L, Neville, Katherine L, Katz-Levy, Yael, Carrizosa, Ana, Kim, Byung S

“…Multiple sclerosis (MS) is a T cell-mediated autoimmune demyelinating disease, which may be initiated by a virus infection. Theiler's murine encephalomyelitis…”
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Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis by Begolka, Wendy Smith, Vanderlugt, Carol L, Rahbe, Sandra M, Miller, Stephen D

“…Multiple sclerosis is an immune-mediated demyelinating disease of unknown etiology that presents with either a chronic-progressive or relapsing-remitting…”
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Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis by Howard, L M, Miga, A J, Vanderlugt, C L, Dal Canto, M C, Laman, J D, Noelle, R J, Miller, S D

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoimmune demyelinating disease model for human multiple…”
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Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE by Theien, Bradley E., Vanderlugt, Carol L., Nickerson-Nutter, Cheryl, Cornebise, Mark, Scott, Daniel M., Perper, Stuart J., Whalley, Eric T., Miller, Stephen D.

“…Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1 (VCAM-1) is required for central nervous system (CNS) migration of…”
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Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE by Miller, Stephen D., Vanderlugt, Carol L., Lenschow, Deborah J., Pope, Jonathan G., Karandikar, Nitin J., Dal Canto, Mauro C., Bluestone, Jeffrey A.

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) induced with the immunodominant epitope from proteolipid protein, PLP 139–151, is characterized by…”
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Temporal Development of Autoreactive Th1 Responses and Endogenous Presentation of Self Myelin Epitopes by Central Nervous System-Resident APCs in Theiler's Virus-Infected Mice by Katz-Levy, Yael, Neville, Katherine L, Padilla, Josette, Rahbe, Sandra, Begolka, Wendy S, Girvin, Ann M, Olson, Julie K, Vanderlugt, Carol L, Miller, Stephen D

“…Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is a chronic-progressive, immune-mediated CNS demyelinating disease and a…”
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CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis by Karandikar, Nitin J, Eagar, Todd N, Vanderlugt, Carol L, Bluestone, Jeffrey A, Miller, Stephen D

“…During the progression of relapsing experimental autoimmune encephalomyelitis (R-EAE), in SJL mice, disease relapses are mediated by T cells specific for…”
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Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune Encephalomyelitis by Karandikar, Nitin J, Vanderlugt, Carol L, Eagar, Todd, Tan, Litjen, Bluestone, Jeffrey A, Miller, Stephen D

“…B7/CD28-mediated costimulation is a promising target for therapeutic intervention in autoimmune diseases. However, studies addressing the differential…”
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Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis by Mack, Cara L, Vanderlugt-Castaneda, Carol L, Neville, Katherine L, Miller, Stephen D

“…Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a well-characterized murine model of the chronic-progressive form of human…”
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Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler’s virus–infected mice by Katz-Levy, Yael, Neville, Katherine L., Girvin, Ann M., Vanderlugt, Carol L., Pope, Jonathan G., Tan, Lit Jen, Miller, Stephen D.

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Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus by Pope, J G, Vanderlugt, C L, Rahbe, S M, Lipton, H L, Miller, S D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease by Karandikar, Nitin J, Vanderlugt, Carol L, Bluestone, Jeffrey A, Miller, Stephen D

“…The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immmune responses (activation vs. down-regulation) and is a highly…”
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Lymphocytes from mice chronically infected with Theiler’s murine encephalomyelitis virus produce demyelination of organotypic cultures after stimulation with the major encephalitogenic epitope of myelin proteolipid protein. Epitope spreading in TMEV infection has functional activity by Dal Canto, Mauro C, Calenoff, Miriam A, Miller, Stephen D, Vanderlugt, Carol L

“…Theiler’s murine encephalomyelitis virus (TMEV) infection produces a chronic inflammatory disease of the spinal cord white matter, with striking similarities…”
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CD8 + T cells from Theiler’s virus-resistant BALB/cByJ mice downregulate pathogenic virus-specific CD4 + T cells by Haynes, Lia M, Vanderlugt, Carol L, Dal Canto, Mauro C, Melvold, Roger W, Miller, Stephen D

“…Theiler’s murine encephalomyelitis virus (TMEV) is a picornavirus which induces an immune-mediated demyelinating disease in susceptible strains of mice and…”
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Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE by Vanderlugt, Carol L, Karandikar, Nitin J, Lenschow, Deborah J, Dal Canto, Mauro C, Bluestone, Jeffrey A, Miller, Stephen D

“…PLP139–151-induced experimental autoimmune encephalomyelitis in the SJL mouse is a Th1-mediated inflammatory demyelinating disease characterized by a…”
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The role of protective CD8 + T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: regulatory vs. lytic by Nicholson, Simone M, Haynes, Lia M, Vanderlugt, Carol L, Miller, Stephen D, Melvold, Roger W

“…Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c…”
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CTLA-4: a negative regulator of autoimmune disease by Karandikar, N J, Vanderlugt, C L, Walunas, T L, Miller, S D, Bluestone, J A

“…CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to…”
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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis by McRae, B L, Vanderlugt, C L, Dal Canto, M C, Miller, S D

“…The role of epitope spreading in the pathology of relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) was examined. Using peripherally…”
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