Search Results - "Vanderlaan, Martin"

Host cell protein testing by ELISAs and the use of orthogonal methods by Zhu-Shimoni, Judith, Yu, Christopher, Nishihara, Julie, Wong, Robert M., Gunawan, Feny, Lin, Margaret, Krawitz, Denise, Liu, Peter, Sandoval, Wendy, Vanderlaan, Martin

“…ABSTRACT Host cell proteins (HCPs) are among the process‐related impurities monitored during recombinant protein pharmaceutical process development. The…”
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Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro by YANING WANG, FEI, David, VANDERLAAN, Martin, AN SONG

“…Bevacizumab (Avastin, Genentech) is a humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), a critical angiogenic factor involved…”
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Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities by Chung, Shan, Quarmby, Valerie, Gao, Xiaoying, Ying, Yong, Lin, Linda, Reed, Chae, Fong, Chris, Lau, Wendy, Qiu, Zhihua J., Shen, Amy, Vanderlaan, Martin, Song, An

“…The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward FcγRIIIa as well as their…”
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Industrial Purification of Pharmaceutical Antibodies: Development, Operation, and Validation of Chromatography Processes by Fahrner, Robert L., Knudsen, Heather L., Basey, Carol D., Galan, Walter, Feuerhelm, Dian, Vanderlaan, Martin, Blank, Gregory S.

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Performance comparison of Protein A affinity-chromatography sorbents for purifying recombinant monoclonal antibodies by Fahrner, Robert L., Whitney, Duncan H., Vanderlaan, Martin, Blank, Gregory S.

“…We describe the performance characteristics of five Protein A affinity‐chromatography sorbents (Sepharose Fast Flow, Poros 50, Poros LP, Prosep and Streamline)…”
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Experience with host cell protein impurities in biopharmaceuticals by Vanderlaan, Martin, Zhu‐Shimoni, Judith, Lin, Sansan, Gunawan, Feny, Waerner, Thomas, Van Cott, Kevin E.

“…In the 40‐year history of biopharmaceuticals, there have been a few cases where the final products contained residual host cell protein (HCP) impurities at…”
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Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product by Vanderlaan, Martin, Maniatis, Aristides, Olney, Robert, Rahmaoui, Abdelkader, Yau, Linda, Quarmby, Valerie, Azzolino, Craig, Woods, Cynthia, Moawad, Dalia

“…Manufacturing process changes may alter the characteristics of a protein therapeutic. In 2009, somatropin (version 1.0), a recombinant human growth hormone…”
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Mass spectrometric evaluation of upstream and downstream process influences on host cell protein patterns in biopharmaceutical products by Falkenberg, Heiner, Waldera‐Lupa, Daniel Michael, Vanderlaan, Martin, Schwab, Thomas, Krapfenbauer, Kurt, Studts, Joey Michael, Flad, Thomas, Waerner, Thomas

“…For production of different monoclonal antibodies (mAbs), biopharmaceutical companies often use related upstream and downstream manufacturing processes. Such…”
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Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane by Ieva, Raffaele, Schrempp, Sandra G., Opaliński, Łukasz, Wollweber, Florian, Höß, Philipp, Heißwolf, Anna K., Gebert, Michael, Zhang, Ying, Guiard, Bernard, Rospert, Sabine, Becker, Thomas, Chacinska, Agnieszka, Pfanner, Nikolaus, van der Laan, Martin

“…The majority of preproteins destined for mitochondria carry N-terminal presequences. The presequence translocase of the inner mitochondrial membrane (TIM23…”
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Host cell proteins in biotechnology-derived products: A risk assessment framework by de Zafra, Christina L. Zuch, Quarmby, Valerie, Francissen, Kathleen, Vanderlaan, Martin, Zhu-Shimoni, Judith

“…ABSTRACT To manufacture biotechnology products, mammalian or bacterial cells are engineered for the production of recombinant therapeutic human proteins…”
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More similar than different: Host cell protein production using three null CHO cell lines by Yuk, Inn H., Nishihara, Julie, Walker Jr, Donald, Huang, Eric, Gunawan, Feny, Subramanian, Jayashree, Pynn, Abigail F.J., Yu, X.Christopher, Zhu-Shimoni, Judith, Vanderlaan, Martin, Krawitz, Denise C.

“…ABSTRACT To understand the diversity in the cell culture harvest (i.e., feedstock) provided for downstream processing, we compared host cell protein (HCP)…”
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One-step purification of mouse monoclonal antibodies from ascites fluid by hydroxylapatite chromatography by Stanker, L H, Vanderlaan, M, Juarez-Salinas, H

“…A single-step method for purification of mouse monoclonal antibodies directly from ascitic fluids using hydroxylapatite column chromatography is described. The…”
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Monoclonal antibodies for dioxin: antibody characterization and assay development by Stanker, L H, Watkins, B, Rogers, N, Vanderlaan, M

“…A set of 5 anti-dioxin monoclonal antibodies (mAbs), named DD-1, DD-3, DD-4, DD-5 and DD-6, have been isolated. In order to evaluate the ability of these mAbs…”
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Trace level analysis of leached Protein A in bioprocess samples without interference from the large excess of rhMAb IgG by Zhu-Shimoni, Judith, Gunawan, Feny, Thomas, Anne, Vanderlaan, Martin, Stults, John

“…Resins containing immobilized Staphylococcal Protein A (PA) are widely used in the commercial purification of recombinant human monoclonal antibody (rhuMAb…”
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Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1 by Yan, Boxu, Boyd, Daniel, Kaschak, Timothy, Tsukuda, Joni, Shen, Amy, Lin, Yuwen, Chung, Shan, Gupta, Priyanka, Kamath, Amrita, Wong, Anne, Vernes, Jean-Michel, Meng, Gloria Y., Totpal, Klara, Schaefer, Gabriele, Jiang, Guoying, Nogal, Bartek, Emery, Craig, Vanderlaan, Martin, Carter, Paul, Harris, Reed, Amanullah, Ashraf

“…Upper hinge is vulnerable to radical attacks that result in breakage of the heavy-light chain linkage and cleavage of the hinge of an IgG1. To further explore…”
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Effects of diet and folate on levels of micronucleated polychromatic erythrocytes by Tucker, J D, Vanderlaan, M, Kwan, T C, Moore, 2nd, D H, Felton, J S

“…We describe a study examining the effects of fried beef consumption on the frequency of micronuclei in RNA-positive polychromatic erythrocytes (PCEs) in…”
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Comparison of the Escherichia coli proteomes for recombinant human growth hormone producing and nonproducing fermentations by Champion, Kathleen M., Nishihara, Julie C., Aldor, Ilana S., Moreno, G. Tony, Andersen, Dana, Stults, Kathy L., Vanderlaan, Martin

“…Two‐dimensional electrophoretic analyses of Escherichia coli cells producing recombinant human growth hormone (Nutropin™) in fermentations were conducted. The…”
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Affinity–reversed-phase liquid chromatography assay to quantitate recombinant antibodies and antibody fragments in fermentation broth by Battersby, John E, Snedecor, Brad, Chen, Christina, Champion, Kathleen M, Riddle, Lavon, Vanderlaan, Martin

“…An automated dual-column liquid chromatography assay comprised of affinity and reversed-phase separations that quantifies the majority of antibody-related…”
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Rat Skin Tumor Incidence Following Single and Fractionated Exposures to Proton Radiation by Burns, Fredric J., Strickland, Paul, Vanderlaan, Martin, Albert, Roy E.

“…Experiments were conducted to establish the dose-response curve and degree of split-dose recovery for tumor induction and hair follicle survival in rat skin…”
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A two-dimensional protein map of Chinese hamster ovary cells by Champion, Kathleen M., Arnott, David, Henzel, William J., Hermes, Sam, Weikert, Stefanie, Stults, John, Vanderlaan, Martin, Krummen, Lynne

“…Chinese hamster ovary (CHO) cells are used extensively for the expression of biopharmaceutical protein products. As part of our effort to better understand CHO…”
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