Search Results - "Vandeputte, Marthe M."

In vitro functional assays as a tool to study new synthetic opioids at the μ-opioid receptor: Potential, pitfalls and progress by Vandeputte, Marthe M., Vasudevan, Lakshmi, Stove, Christophe P.

“…New psychoactive substances (NPS), formerly also referred to as “designer drugs”, are often synthetic derivatives of existing psychoactive drugs, their diverse…”
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Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs by Vandeputte, Marthe M., Walton, Sara E., Shuda, Sarah A., Papsun, Donna M., Krotulski, Alex J., Stove, Christophe P.

“…The emergence of structurally diverse new synthetic opioids (NSOs) has caused the opioid crisis to spiral to new depths. Little information is available about…”
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Nitazene test strips: a laboratory evaluation by De Vrieze, Liam M, Stove, Christophe P, Vandeputte, Marthe M

“…2-Benzylbenzimidazole 'nitazene' opioids pose a growing threat to public health. Nitazene analogues are increasingly found mixed with or (mis)sold as heroin…”
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Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays by Grafinger, Katharina Elisabeth, Vandeputte, Marthe M., Cannaert, Annelies, Ametovski, Adam, Sparkes, Eric, Cairns, Elizabeth, Juchli, Patrick Osamu, Haschimi, Belal, Pulver, Benedikt, Banister, Samuel D., Stove, Christophe P., Auwärter, Volker

“…The present work is the last of a three‐part study investigating a panel of 30 systematically designed synthetic cannabinoid receptor agonists (SCRAs)…”
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In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances by Vandeputte, Marthe M., Cannaert, Annelies, Stove, Christophe P.

“…The landscape of new psychoactive substances (NPS) is constantly evolving, with new compounds entering the illicit drug market at a continuous pace. Of these,…”
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The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament by Vandeputte, Marthe M, Krotulski, Alex J, Papsun, Donna M, Logan, Barry K, Stove, Christophe P

“…Abstract Synthetic opioids constitute one of the fastest-growing groups of new psychoactive substances (NPS) worldwide. With fentanyl analogues being…”
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First Report on Brorphine: The Next Opioid on the Deadly New Psychoactive Substance Horizon? by Verougstraete, Nick, Vandeputte, Marthe M, Lyphout, Cathelijne, Cannaert, Annelies, Hulpia, Fabian, Van Calenbergh, Serge, Verstraete, Alain G, Stove, Christophe

“…Abstract New psychoactive substances continue to appear on the drug market. Until recently, new synthetic opioids, which are among the most dangerous new…”
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In vitro μ‐opioid receptor activation potential of U10 and β‐U10, positional isomers of the synthetic opioid naphthyl U‐47700 by Vandeputte, Marthe M., Stove, Christophe P.

“…New synthetic opioids (NSOs) with diverse chemical structures continue to appear on recreational drug markets worldwide. U‐type opioids have become one of the…”
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Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole ‘nitazene’ synthetic opioid by Vandeputte, Marthe M., Krotulski, Alex J., Walther, Donna, Glatfelter, Grant C., Papsun, Donna, Walton, Sara E., Logan, Barry K., Baumann, Michael H., Stove, Christophe P.

“…Novel synthetic opioids continue to emerge on recreational drug markets worldwide. In response to legislative bans on fentanyl analogues, non-fentanyl…”
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Synthesis, Chemical Characterization, and μ‑Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2‑Benzylbenzimidazole Synthetic Opioids by Vandeputte, Marthe M, Van Uytfanghe, Katleen, Layle, Nathan K, St. Germaine, Danielle M, Iula, Donna M, Stove, Christophe P

“…Several 2-benzylbenzimidazole opioids (also referred to as “nitazenes”) recently emerged on the illicit market. The most frequently encountered member,…”
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Alkoxy chain length governs the potency of 2-benzylbenzimidazole ‘nitazene’ opioids associated with human overdose by Glatfelter, Grant C., Vandeputte, Marthe M., Chen, Li, Walther, Donna, Tsai, Meng-Hua M., Shi, Lei, Stove, Christophe P., Baumann, Michael H.

“…Rationale Novel synthetic opioids (NSOs) are emerging in recreational drug markets worldwide. In particular, 2-benzylbenzimidazole ‘nitazene’ compounds are…”
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Toxicological and pharmacological characterization of novel cinnamylpiperazine synthetic opioids in humans and in vitro including 2-methyl AP-237 and AP-238 by Fogarty, Melissa F., Vandeputte, Marthe M., Krotulski, Alex J., Papsun, Donna, Walton, Sara E., Stove, Christophe P., Logan, Barry K.

“…The recent scheduling actions of fentanyl-related substances in both the United States and China have sparked the emergence and proliferation of other…”
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Detection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole “nitazene” class by Monti, Manuela C., De Vrieze, Liam M., Vandeputte, Marthe M., Persson, Mattias, Gréen, Henrik, Stove, Christophe P., Schlotterbeck, Götz

“…The emergence of 2-benzylbenzimidazole “nitazene” opioids is stirring up the recreational synthetic opioid market. Many nitazene analogues act as potent…”
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Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide by Vandeputte, Marthe M., Tsai, Meng-Hua M., Chen, Li, Glatfelter, Grant C., Walther, Donna, Stove, Christophe P., Shi, Lei, Baumann, Michael H.

“…The emergence of novel synthetic opioids (NSOs) is contributing to the opioid overdose crisis. While fentanyl analogs have historically dominated the NSO…”
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First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass by Vandeputte, Marthe M., Verougstraete, Nick, Walther, Donna, Glatfelter, Grant C., Malfliet, Jeroen, Baumann, Michael H., Verstraete, Alain G., Stove, Christophe P.

“…N -Piperidinyl etonitazene (‘etonitazepipne’) represents a recent addition to the rapidly expanding class of 2-benzylbenzimidazole ‘nitazene’ opioids…”
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Phenethyl-4-ANPP: A Marginally Active Byproduct Suggesting a Switch in Illicit Fentanyl Synthesis Routes by Vandeputte, Marthe M, Krotulski, Alex J, Hulpia, Fabian, Van Calenbergh, Serge, Stove, Christophe P

“…Abstract Profiling of the illicit fentanyl supply is invaluable from surveillance and intelligence perspectives. An important strategy includes the study of…”
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Characterization of recent non-fentanyl synthetic opioids via three different in vitro µ-opioid receptor activation assays by Vandeputte, Marthe M., Persson, Mattias, Walther, Donna, Vikingsson, Svante, Kronstrand, Robert, Baumann, Michael H., Gréen, Henrik, Stove, Christophe P.

“…New synthetic opioids (NSOs) are one of the fastest growing groups of new psychoactive substances. Amid this dynamic landscape, insight into the pharmacology…”
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Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization by Vandeputte, Marthe M., Bilel, Sabrine, Tirri, Micaela, Corli, Giorgia, Bassi, Marta, Layle, Nathan K., Fantinati, Anna, Walther, Donna, Iula, Donna M., Baumann, Michael H., Stove, Christophe P., Marti, Matteo

“…The emergence of new synthetic opioids (NSOs) has added complexity to recreational opioid markets worldwide. While NSOs with diverse chemical structures have…”
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Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice by Vandeputte, Marthe M., Glatfelter, Grant C., Walther, Donna, Layle, Nathan K., St. Germaine, Danielle M., Ujváry, István, Iula, Donna M., Baumann, Michael H., Stove, Christophe P.

“…2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacological…”
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In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids by De Vrieze, Liam M., Walton, Sara E., Pottie, Eline, Papsun, Donna, Logan, Barry K., Krotulski, Alex J., Stove, Christophe P., Vandeputte, Marthe M.

“…2-Benzylbenzimidazole ‘nitazene’ opioids are presenting a growing threat to public health. Although various nitazenes were previously studied, systematic…”
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