Search Results - "Vandeput, Fabrice"

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2 by Zoccarato, Anna, Surdo, Nicoletta C, Aronsen, Jan M, Fields, Laura A, Mancuso, Luisa, Dodoni, Giuliano, Stangherlin, Alessandra, Livie, Craig, Jiang, He, Sin, Yuan Yan, Gesellchen, Frank, Terrin, Anna, Baillie, George S, Nicklin, Stuart A, Graham, Delyth, Szabo-Fresnais, Nicolas, Krall, Judith, Vandeput, Fabrice, Movsesian, Matthew, Furlan, Leonardo, Corsetti, Veronica, Hamilton, Graham, Lefkimmiatis, Konstantinos, Sjaastad, Ivar, Zaccolo, Manuela

“…RATIONALE:Chronic elevation of 3′-5′-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However,…”
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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54 by Kotani, Masato, Detheux, Michel, Vandenbogaerde, Ann, Communi, David, Vanderwinden, Jean-Marie, Le Poul, Emmanuel, Brézillon, Stéphane, Tyldesley, Richard, Suarez-Huerta, Nathalie, Vandeput, Fabrice, Blanpain, Cédric, Schiffmann, Serge N., Vassart, Gilbert, Parmentier, Marc

“…Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino…”
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Cyclic Nucleotide Phosphodiesterase PDE1C1 in Human Cardiac Myocytes by Vandeput, Fabrice, Wolda, Sharon L., Krall, Judith, Hambleton, Ryan, Uher, Lothar, McCaw, Kim N., Radwanski, Przemyslaw B., Florio, Vincent, Movsesian, Matthew A.

“…Isoforms in the PDE1 family of cyclic nucleotide phosphodiesterases were recently found to comprise a significant portion of the cGMP-inhibited cAMP hydrolytic…”
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cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium by Vandeput, Fabrice, Krall, Judith, Ockaili, Ramzi, Salloum, Fadi N, Florio, Vincent, Corbin, Jackie D, Francis, Sharron H, Kukreja, Rakesh C, Movsesian, Matthew A

“…In mouse models of cardiac disease, the type 5 (PDE5)-selective cyclic nucleotide phosphodiesterase inhibitor sildenafil has antihypertrophic and…”
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Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms by Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Ahmad, Faiyaz, Kho, Changwon, Lee, Ahyoung, Krall, Judith, Dunlop, Allan, Hazel, Mark W., Wohlschlegel, James A., Hajjar, Roger J., Houslay, Miles D., Manganiello, Vincent C., Movsesian, Matthew A.

“…Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in…”
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The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity by Vandeput, Fabrice, Backers, Katrien, Villeret, Vincent, Pesesse, Xavier, Erneux, Christophe

“…The SH2 domain containing inositol 5-phosphatase 2 (SHIP2) catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P 3) to…”
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Phosphodiesterase inhibition in heart failure by Movsesian, Matthew, Stehlik, Josef, Vandeput, Fabrice, Bristow, Michael R.

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Role of the Different Mitogen-Activated Protein Kinase Subfamilies in the Stimulation of Dog and Human Thyroid Epithelial Cell Proliferation by Cyclic Adenosine 5′-Monophosphate and Growth Factors by Vandeput, Fabrice, Perpete, Sandrine, Coulonval, Katia, Lamy, Françoise, Dumont, Jacques E

“…We have investigated the role of the different classes of MAPKs, i.e. ERKs, c-Jun N-terminal kinases (JNKs), and p38 MAPK in the proliferation of dog and human…”
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Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2 by Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent

“…Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart…”
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PDE3 inhibition in dilated cardiomyopathy by Movsesian, Matthew, Wever-Pinzon, Omar, Vandeput, Fabrice

“…Highlights ► In dilated cardiomyopathy, cAMP responses to β-adrenergic receptor agonists are attenuated. ► This results from downregulation of β1 -adrenergic…”
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PDE3A mutations cause autosomal dominant hypertension with brachydactyly by Maass, Philipp G, Aydin, Atakan, Luft, Friedrich C, Schächterle, Carolin, Weise, Anja, Stricker, Sigmar, Lindschau, Carsten, Vaegler, Martin, Qadri, Fatimunnisa, Toka, Hakan R, Schulz, Herbert, Krawitz, Peter M, Parkhomchuk, Dmitri, Hecht, Jochen, Hollfinger, Irene, Wefeld-Neuenfeld, Yvette, Bartels-Klein, Eireen, Mühl, Astrid, Kann, Martin, Schuster, Herbert, Chitayat, David, Bialer, Martin G, Wienker, Thomas F, Ott, Jürg, Rittscher, Katharina, Liehr, Thomas, Jordan, Jens, Plessis, Ghislaine, Tank, Jens, Mai, Knut, Naraghi, Ramin, Hodge, Russell, Hopp, Maxwell, Hattenbach, Lars O, Busjahn, Andreas, Rauch, Anita, Vandeput, Fabrice, Gong, Maolian, Rüschendorf, Franz, Hübner, Norbert, Haller, Hermann, Mundlos, Stefan, Bilginturan, Nihat, Movsesian, Matthew A, Klussmann, Enno, Toka, Okan, Bähring, Sylvia

“…Friedrich Luft and colleagues identify missense mutations in PDE3A in six unrelated families with an autosomal dominant syndrome marked by severe hypertension…”
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Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1 by Humphrey, John M, Movsesian, Matthew, am Ende, Christopher W, Becker, Stacey L, Chappie, Thomas A, Jenkinson, Stephen, Liras, Jennifer L, Liras, Spiros, Orozco, Christine, Pandit, Jayvardhan, Vajdos, Felix F, Vandeput, Fabrice, Yang, Eddie, Menniti, Frank S

“…We disclose the discovery and X-ray cocrystal data of potent, selective quinazoline inhibitors of PDE1. Inhibitor (S)-3 readily attains free plasma…”
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Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin by COULONVAL, Katia, VANDEPUT, Fabrice, STEIN, Rob C., KOZMA, Sara C., LAMY, Françoise, DUMONT, Jacques E.

“…The proliferation of most normal cells depends on the co-operation of several growth factors and hormones, each with a specific role, but the key events…”
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Phosphodiesterase inhibition in heart failure by Movsesian, Matthew, Stehlik, Josef, Vandeput, Fabrice, Bristow, Michael R.

“…Drugs that inhibit cyclic nucleotide phosphodiesterase activity act to increase intracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine…”
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Phosphorylation regulates association of PDE3A isoforms with distinct interactomes (1013.23) by Vandeput, Fabrice, Szabo‐Fresnais, Nicolas, Ahmad, Faiyaz, Kho, Changwon, Lee, Ahyoung, Krall, Judith, Hajjar, Roger, Manganiello, Vincent, Movsesian, Matthew

“…Inhibitors of cyclic nucleotide phosphodiesterase PDE3A have inotropic actions in human myocardium, but their long‐term use increases mortality in patients…”
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Phosphorylation‐dependent Association of PDE3A1 with SERCA2 and its Regulation of SERCA2 Activity in Human Myocardium by Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo‐Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent

“…Abstract only PDE3 regulates cAMP‐mediated signaling in the heart. Studies in mice showed that PDE3A is associated with SERCA2, PLB and AKAP18 in a signaling…”
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Regulation of SERCA2 activity by PDE3A in human myocardium: Phosphorylation-dependent interaction of PDE3A1 with SERCA2 by Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent

“…PDE3 regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that…”
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Selective regulation of PDE3A isoforms by differential phosphorylation by Vandeput, Fabrice, Szabo‐Fresnais, Nicolas, Dunlop, Allan, Krall, Judith, Manganiello, Vincent C., Houslay, Miles D., Movsesian, Matthew A.

“…Abstract only Two isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes, PDE3A1 and PDE3A2, have identical amino‐acid sequences save for a…”
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Regulation of Sarcoplasmic Reticulum Ca2+ ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium by Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent

“…Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart…”
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Subcellular Localization of Human Myocardial PDE3 Isoforms and Components of cAMP Signaling Pathways by Khan, Faiyaz Ahmad, Krall, Judith, Vandeput, Fabrice, Shen, Weixing, Manganiello, Vincent, Movsesian, Matthew

“…Abstract only Caveolae‐enriched plasma membrane (PM) fractions from failing heart myocardium are highly enriched in b2‐ARs, b3‐ARs, Gα (i), adenylyl cyclase…”
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