Search Results - "Vandenberg, Jamie I."

hERG K(+) channels: structure, function, and clinical significance by Vandenberg, Jamie I, Perry, Matthew D, Perrin, Mark J, Mann, Stefan A, Ke, Ying, Hill, Adam P

“…The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are…”
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Towards a Structural View of Drug Binding to hERG K+ Channels by Vandenberg, Jamie I., Perozo, Eduardo, Allen, Toby W.

“…The human ether-a-go-go-related gene (hERG) K+ channel is of great medical and pharmaceutical relevance. Inherited mutations in hERG result in congenital…”
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Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon by Munawar, Saba, Vandenberg, Jamie I, Jabeen, Ishrat

“…Human ether a-go-go related gene (hERG) or KV11.1 potassium channels mediate the rapid delayed rectifier current ( in cardiac myocytes. Drug-induced inhibition…”
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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm by Fermini, Bernard, Hancox, Jules C, Abi-Gerges, Najah, Bridgland-Taylor, Matthew, Chaudhary, Khuram W, Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Erdemli, Gul, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Levesque, Paul, Li, Zhihua, Lindqvist, Anders, Obejero-Paz, Carlos A, Rampe, David, Sawada, Kohei, Strauss, David G, Vandenberg, Jamie I

“…For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia…”
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Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology by Heitmann, Stewart, Vandenberg, Jamie I, Hill, Adam P

“…Many classes of drugs can induce fatal cardiac arrhythmias by disrupting the electrophysiology of cardiomyocytes. Safety guidelines thus require all new drugs…”
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Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics by Chiamvimonvat, Nipavan, Chen‐Izu, Ye, Clancy, Colleen E., Deschenes, Isabelle, Dobrev, Dobromir, Heijman, Jordi, Izu, Leighton, Qu, Zhilin, Ripplinger, Crystal M., Vandenberg, Jamie I., Weiss, James N., Koren, Gideon, Banyasz, Tamas, Grandi, Eleonora, Sanguinetti, Michael C., Bers, Donald M., Nerbonne, Jeanne M.

“…This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation–Contraction…”
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Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes by Ma, Joanne G, Vandenberg, Jamie I, Ng, Chai-Ann

“…Advances in next-generation sequencing have been exceptionally valuable for identifying variants in medically actionable genes. However, for most missense…”
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Potassium channels in the heart: structure, function and regulation by Grandi, Eleonora, Sanguinetti, Michael C., Bartos, Daniel C., Bers, Donald M., Chen‐Izu, Ye, Chiamvimonvat, Nipavan, Colecraft, Henry M., Delisle, Brian P., Heijman, Jordi, Navedo, Manuel F., Noskov, Sergei, Proenza, Catherine, Vandenberg, Jamie I., Yarov‐Yarovoy, Vladimir

“…This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a…”
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1 by Kozek, Krystian A., Glazer, Andrew M., Ng, Chai-Ann, Blackwell, Daniel, Egly, Christian L., Vanags, Loren R., Blair, Marcia, Mitchell, Devyn, Matreyek, Kenneth A., Fowler, Douglas M., Knollmann, Bjorn C., Vandenberg, Jamie I., Roden, Dan M., Kroncke, Brett M.

“…KCHN2 encodes the KV11.1 potassium channel responsible for IKr, a major repolarization current during the cardiomyocyte action potential. Variants in KCNH2…”
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Arrhythmogenic effects of ultra-long and bistable cardiac action potentials by Heitmann, Stewart, Shpak, Anton, Vandenberg, Jamie I, Hill, Adam P

“…Contemporary accounts of the initiation of cardiac arrhythmias typically rely on after-depolarizations as the trigger for reentrant activity. The…”
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Potassium dependent structural changes in the selectivity filter of HERG potassium channels by Lau, Carus H. Y., Flood, Emelie, Hunter, Mark J., Williams-Noonan, Billy J., Corbett, Karen M., Ng, Chai-Ann, Bouwer, James C., Stewart, Alastair G., Perozo, Eduardo, Allen, Toby W., Vandenberg, Jamie I.

“…The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through…”
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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia by Thorpe, Jordan, Perry, Matthew D, Contreras, Osvaldo, Hurley, Emily, Parker, George, Harvey, Richard P, Hill, Adam P, Vandenberg, Jamie I

“…Atrial fibrillation is the most common arrhythmia syndrome and causes significant morbidity and mortality. Current therapeutics, however, have limited…”
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Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels by Clarke, Oliver B., Caputo, Alessandro T., Hill, Adam P., Vandenberg, Jamie I., Smith, Brian J., Gulbis, Jacqueline M.

“…Potassium channels embedded in cell membranes employ gates to regulate K + current. While a specific constriction in the permeation pathway has historically…”
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R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy by Mann, Stefan A., PhD, Castro, Maria L., BMedSci(Hons), Ohanian, Monique, BMedSci(Hons), Guo, Guanglan, PhD, Zodgekar, Poonam, MSW, GradDipGenCouns, Sheu, Angela, MB, BS, Stockhammer, Kathryn, BSc, GradDipGenCouns, Thompson, Tina, BNurs, Playford, David, MB, BS, PhD, Subbiah, Rajesh, MB, BS, PhD, Kuchar, Dennis, MD, Aggarwal, Anu, MB, BS, PhD, Vandenberg, Jamie I., MB, BS, PhD, Fatkin, Diane, MD

“…Objectives The goal of this study was to characterize a variant in the SCN5A gene that encodes the alpha-subunit of the cardiac sodium channel, Nav1.5, which…”
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Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels by Ng, Chai Ann, Phan, Kevin, Hill, Adam P., Vandenberg, Jamie I., Perry, Matthew D.

“…The intracellular domains of many ion channels are important for fine-tuning their gating kinetics. In Kv11.1 channels, the slow kinetics of channel…”
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Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy by Lim, Seakcheng, Mangala, Melissa M, Holliday, Mira, Cserne Szappanos, Henrietta, Barratt-Ross, Samantha, Li, Serena, Thorpe, Jordan, Liang, Whitney, Ranpura, Ginell N, Vandenberg, Jamie I, Semsarian, Christopher, Hill, Adam P, Hool, Livia C

“…Hypertrophic cardiomyopathy (HCM) is an inherited heart muscle disease that is characterised by left ventricular wall thickening, cardiomyocyte disarray and…”
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Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities by Munawar, Saba, Windley, Monique J, Tse, Edwin G, Todd, Matthew H, Hill, Adam P, Vandenberg, Jamie I, Jabeen, Ishrat

“…The hERG (human ether-a-go-go-related gene) encoded potassium ion (K ) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has…”
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Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels by Perrin, Mark J, Kuchel, Philip W, Campbell, Terence J, Vandenberg, Jamie I

“…Drug block of the human ether-à-go-go-related gene K(+) channel (hERG) is the most common cause of acquired long QT syndrome, a disorder of cardiac…”
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The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review by Tardo, Daniel T., Peck, Matthew, Subbiah, Rajesh N., Vandenberg, Jamie I., Hill, Adam. P.

“…Introduction QTc prolongation is key in diagnosing long QT syndrome (LQTS), however 25%–50% with congenital LQTS (cLQTS) demonstrate a normal resting QTc. T…”
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