Search Results - "Vandana, J. Jeya"

SARS-CoV-2 infection induces beta cell transdifferentiation by Tang, Xuming, Uhl, Skyler, Zhang, Tuo, Xue, Dongxiang, Li, Bo, Vandana, J. Jeya, Acklin, Joshua A., Bonnycastle, Lori L., Narisu, Narisu, Erdos, Michael R., Bram, Yaron, Chandar, Vasuretha, Chong, Angie Chi Nok, Lacko, Lauretta A., Min, Zaw, Lim, Jean K., Borczuk, Alain C., Xiang, Jenny, Naji, Ali, Collins, Francis S., Evans, Todd, Liu, Chengyang, tenOever, Benjamin R., Schwartz, Robert E., Chen, Shuibing

“…Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral…”
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Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter by Sengar, Anjali, Vandana, J Jeya, Chambers, Vicki S, Di Antonio, Marco, Winnerdy, Fernaldo Richtia, Balasubramanian, Shankar, Phan, Anh Tuân

“…Abstract Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition…”
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NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes by Winnerdy, Fernaldo Richtia, Bakalar, Blaž, Maity, Arijit, Vandana, J Jeya, Mechulam, Yves, Schmitt, Emmanuelle, Phan, Anh Tuân

“…Abstract Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous…”
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Modeling cancer progression using human pluripotent stem cell-derived cells and organoids by Zhang, Meili, Vandana, J. Jeya, Lacko, Lauretta, Chen, Shuibing

“…•hPSC-derived cells and organoids provide a powerful tool to study cancer progression.•hPSC-derived cells have been applied to elucidate the cancer…”
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Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation by Vandana, J. Jeya, Manrique, Cassandra, Lacko, Lauretta A., Chen, Shuibing

“…Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a new era for disease modeling and drug discovery. Over the past decade,…”
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Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis by Vandana, J Jeya, Lacko, Lauretta A, Chen, Shuibing

“…Using an automatic microfluidics droplet platform, Ding et al. successfully replicated the tumor micro-environment by generating micro-organospheres, which…”
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Phenotypic technologies in stem cell biology by Vandana, J Jeya, Lacko, Lauretta A, Chen, Shuibing

“…The high-throughput phenotypic screen (HTPS) has become an emerging technology to discover synthetic small molecules that regulate stem cell fates. Here, we…”
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Formation of RNA G-wires by G4C2 repeats associated with ALS and FTD by Bose, Krishnashish, Maity, Arijit, Ngo, Khac Huy, Vandana, J. Jeya, Shneider, Neil A., Phan, Anh Tuân

“…In the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), expansion of the G4C2 hexanucleotide repeat in the…”
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Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure by Zhan, Xuan, Deng, Liping, Lian, Yun, Shu, Zhiyu, Xu, Yunong, Mai, Xinyi, Krishna, Manchugondanahalli S., Lu, Rongguang, Wang, Anni, Bai, Shiyao, Zhou, Fangyu, Xiong, Chi, Xu, Yingyi, Ni, Jie, Vandana, J. Jeya, Wang, Zi, Li, Yuqing, Sun, Dongmei, Huang, Shaohui, Liu, Jingyan, Cheng, Gui-Juan, Wu, Song, Chiang, Ying-Chih, Stjepanovic, Goran, Jiang, Cheng, Shao, Yong, Chen, Gang

“…The small molecule epiberberine (EPI) is a natural alkaloid with versatile bioactivities against several diseases including cancer and bacterial infection. EPI…”
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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis by Chong, Angie Chi Nok, Vandana, J. Jeya, Jeng, Ginnie, Li, Ge, Meng, Zihe, Duan, Xiaohua, Zhang, Tuo, Qiu, Yunping, Duran-Struuck, Raimon, Coker, Kimberly, Wang, Wei, Li, Yanjing, Min, Zaw, Zuo, Xi, de Silva, Neranjan, Chen, Zhengming, Naji, Ali, Hao, Mingming, Liu, Chengyang, Chen, Shuibing

“…After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a…”
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Students’ Perspective on Scientific Training by Chua, Gabriella N. L., Vandana, J. Jeya, Hsieh, Chun‐Cheng

“…How should lab heads train their students and what is the role of degree‐granting institutions in this process? Chua, Vandana, and Hsieh discuss the needs of…”
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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells by Xue, Dongxiang, Narisu, Narisu, Taylor, D Leland, Zhang, Meili, Grenko, Caleb, Taylor, Henry J, Yan, Tingfen, Tang, Xuming, Sinha, Neelam, Zhu, Jiajun, Vandana, J Jeya, Nok Chong, Angie Chi, Lee, Angela, Mansell, Erin C, Swift, Amy J, Erdos, Michael R, Zhong, Aaron, Bonnycastle, Lori L, Zhou, Ting, Chen, Shuibing, Collins, Francis S

“…Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the functional roles of many loci remain unexplored. Here, we…”
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Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for −1 ribosomal frameshifting stimulation by Zhong, Zhensheng, Yang, Lixia, Zhang, Haiping, Shi, Jiahao, Vandana, J. Jeya, Lam, Do Thuy Uyen Ha, Olsthoorn, René C. L., Lu, Lanyuan, Chen, Gang

“…Minus-one ribosomal frameshifting is a translational recoding mechanism widely utilized by many RNA viruses to generate accurate ratios of structural and…”
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283-OR: ADA Presidents' Select Abstract: An Isogenic hPSC-Based Platform for Functional Interrogation of the Role of Multiple T2D-Associated Genes in Pancreatic Beta-Cell Failure by XUE, DONGXIANG, NARISU, NARISU, YAN, TINGFEN, ZHANG, MEILI, GRENKO, CALEB, TANG, XUMING, ZHU, JIAJUN, BONNYCASTLE, LORI L., ERDOS, MICHAEL, VANDANA, J JEYA, CHONG, ANGIE, COLLINS, FRANCIS S., CHEN, SHUIBING

“…Type 2 diabetes (T2D) mellitus is a complex polygenic disease. Multiple genome-wide association studies (GWAS) have identified hundreds of T2D-related genetic…”
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Formation of RNA G-wires by G 4 C 2 repeats associated with ALS and FTD by Bose, Krishnashish, Maity, Arijit, Ngo, Khac Huy, Vandana, J Jeya, Shneider, Neil A, Phan, Anh Tuân

“…In the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), expansion of the G C hexanucleotide repeat in the…”
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