Search Results - "VanLoock, Margaret S"

ATP-Mediated Conformational Changes in the RecA Filament by VanLoock, Margaret S., Yu, Xiong, Yang, Shixin, Lai, Alex L., Low, Claudia, Campbell, Michael J., Egelman, Edward H.

“…The crystal structure of the E. coli RecA protein was solved more than 10 years ago, but it has provided limited insight into the mechanism of homologous…”
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ADF/Cofilin Use an Intrinsic Mode of F-Actin Instability to Disrupt Actin Filaments by Galkin, Vitold E., Orlova, Albina, VanLoock, Margaret S., Shvetsov, Alexander, Reisler, Emil, Egelman, Edward H.

“…Proteins in the ADF/cofilin (AC) family are essential for rapid rearrangements of cellular actin structures. They have been shown to be active in both the…”
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A New Internal Mode in F-Actin Helps Explain the Remarkable Evolutionary Conservation of Actin's Sequence and Structure by Galkin, Vitold E., VanLoock, Margaret S., Orlova, Albina, Egelman, Edward H.

“…Actin is one of the most highly conserved eukaryotic proteins. There are no amino acid changes between the chicken and human skeletal muscle isoforms, and the…”
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The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings by Yu, Xiong, VanLoock, Margaret S, Poplawski, Andrzej, Kelman, Zvi, Xiang, Tao, Tye, Bik K, Egelman, Edward H

“…Mini‐chromosome maintenance (MCM) proteins form a conserved family found in all eukaryotes and are essential for DNA replication. They exist as…”
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How Does ATP Hydrolysis Control Actin's Associations? by Sablin, Elena P., Dawson, John F., VanLoock, Margaret S., Spudich, James A., Egelman, Edward H., Fletterick, Robert J.

“…Polymers of actin (F-actin) form an integral part of the structural framework that supports the plasma membrane of cells while providing a platform for…”
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Salmonella SipA Polymerizes Actin by Stapling Filaments with Nonglobular Protein Arms by Lilic, Mirjana, Galkin, Vitold E., Orlova, Albina, VanLoock, Margaret S., Egelman, Edward H., Stebbins, C. Erec

“…Like many bacterial pathogens, Salmonella spp. use a type III secretion system to inject virulence proteins into host cells. The Salmonella invasion protein A…”
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Flexibility of the Rings: Structural Asymmetry in the DnaB Hexameric Helicase by Yang, Shixin, Yu, Xiong, VanLoock, Margaret S, Jezewska, Maria J, Bujalowski, Wlodzimierz, Egelman, Edward H

“…DnaB is the primary replicative helicase in Escherichia coli and the hexameric DnaB ring has previously been shown to exist in two states in the presence of…”
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Complexes of RecA with LexA and RecX Differentiate Between Active and Inactive RecA Nucleoprotein Filaments by VanLoock, Margaret S., Yu, Xiong, Yang, Shixin, Galkin, Vitold E., Huang, Hao, Rajan, Shyamala S., Anderson, Wayne F., Stohl, Elizabeth A., Seifert, H.Steven, Egelman, Edward H.

“…The bacterial RecA protein has been the dominant model system for understanding homologous genetic recombination. Although a crystal structure of RecA was…”
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Do the utrophin tandem calponin homology domains bind F-actin in a compact or extended conformation? by Galkin, Vitold E, Orlova, Albina, VanLoock, Margaret S, Egelman, Edward H

“…Tandem calponin-homology (CH) domains play an important role in the actin-binding function of many spectrin superfamily proteins. Crystal structures from…”
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The Utrophin Actin-Binding Domain Binds F-Actin in Two Different Modes: Implications for the Spectrin Superfamily of Proteins by Galkin, Vitold E, Orlova, Albina, VanLoock, Margaret S, Rybakova, Inna N, Ervasti, James M, Egelman, Edward H

“…Utrophin, like its homologue dystrophin, forms a link between the actin cytoskeleton and the extracellular matrix. We have used a new method of image analysis…”
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SV40 Large T Antigen Hexamer Structure: Domain Organization and DNA-Induced Conformational Changes by VanLoock, Margaret S., Alexandrov, Alexander, Yu, Xiong, Cozzarelli, Nicholas R., Egelman, Edward H.

“…Simian Virus 40 replication requires only one viral protein, the Large T antigen (T-ag), which acts as both an initiator of replication and as a replicative…”
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Each actin subunit has three nebulin binding sites: implications for steric blocking by Lukoyanova, Natalya, VanLoock, Margaret S, Orlova, Albina, Galkin, Vitold E, Wang, Kuan, Egelman, Edward H

“…Nebulin is a giant protein that spans most of the muscle thin filament. Mutations in nebulin result in myopathies and dystrophies. Nebulin contains…”
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The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin by Egelman, Edward H, Galkin, Vitold E, Orlova, Albina, VanLoock, Margaret S, Zhou, Daoguo, Galán, Jorge E

“…SipA is a Salmonella protein delivered into host cells to promote efficient bacterial entry, which is essential for pathogenicity. SipA exerts its function by…”
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Comparison of bacteriophage T4 UvsX and human Rad51 filaments suggests that RecA-like polymers may have evolved independently by Yang, Shixin, VanLoock, Margaret S, Yu, Xiong, Egelman, Edward H

“…The UvsX protein from bacteriophage T4 is a member of the RecA/Rad51/RadA family of recombinases active in homologous genetic recombination. Like RecA, Rad51…”
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The primase active site is on the outside of the hexameric bacteriophage T7 gene 4 helicase-primase ring by VanLoock, Margaret S, Chen, Yen-Ju, Yu, Xiong, Patel, Smita S, Egelman, Edward H

“…Gene 4 of bacteriophage T7 encodes a protein (gp4) that can translocate along single-stranded DNA, couple the unwinding of duplex DNA with the hydrolysis of…”
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The Location of Ubiquitin in Lethocerus Arthrin by Galkin, Vitold E., Orlova, Albina, Lukoyanova, Natalya, VanLoock, Margaret S., Hååg, Petra, Bullard, Belinda, Egelman, Edward H.

“…Arthrin is a ubiquitinated actin that is present in flight muscles of some insects. In addition, it has been found in the malaria parasite Plasmodium…”
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Each Actin Subunit Has Three Nebulin Binding Sites by Lukoyanova, Natalya, VanLoock, Margaret S., Orlova, Albina, Galkin, Vitold E., Wang, Kuan, Egelman, Edward H.

“…Nebulin is a giant protein that spans most of the muscle thin filament [1, 2]. Mutations in nebulin result in myopathies and dystrophies [3, 4]. Nebulin…”
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Exploring three-dimensional structures of the HIV-1 RNA/tRNA Lys3 initiation complex 1 1Edited by D. E. Draper by Elgavish, Tricia, VanLoock, Margaret S., Harvey, Stephen C.

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Probing the structure of F-actin: cross-links constrain atomic models and modify actin dynamics 1 1Edited by M. F. Moody by Orlova, Albina, Galkin, Vitold E, VanLoock, Margaret S, Kim, Eldar, Shvetsov, Alexander, Reisler, Emil, Egelman, Edward H

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Movement of the Decoding Region of the 16 S Ribosomal RNA Accompanies tRNA Translocation by VanLoock, Margaret S., Agrawal, Rajendra K., Gabashvili, Irene S., Qi, Li, Frank, Joachim, Harvey, Stephen C.

“…The ribosome undergoes pronounced periodic conformational changes during protein synthesis. Of particular importance are those occurring around the decoding…”
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