Search Results - "VanCott, John L"

Mice Develop Effective but Delayed Protective Immune Responses When Immunized as Neonates either Intranasally with Nonliving VP6/LT(R192G) or Orally with Live Rhesus Rotavirus Vaccine Candidates by VANCOTT, John L, PRADA, Anne E, CHOI, Anthony H.-C, WARD, Richard L, MCNEAL, Monica M, STONE, Susan C, BASU, Mitali, HUFFER, Bert, SMILEY, Kristi L, SHAO, Mingyuan, BEAN, Judy A, CLEMENTS, John D

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CD4 T Cells Are the Only Lymphocytes Needed To Protect Mice against Rotavirus Shedding after Intranasal Immunization with a Chimeric VP6 Protein and the Adjuvant LT(R192G) by McNeal, Monica M, VanCott, John L, Choi, Anthony H C, Basu, Matili, Flint, Jason A, Stone, Susan C, Clements, John D, Ward, Richard L

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Intranasal or oral immunization of inbred and outbred mice with murine or human rotavirus VP6 proteins protects against viral shedding after challenge with murine rotaviruses by Choi, Anthony H, McNeal, Monica M, Basu, Mitali, Flint, Jason A, Stone, Susan C, Clements, John D, Bean, Judy A, Poe, Stacey A, VanCott, John L, Ward, Richard L

“…Intranasal (i.n.) administration of an Escherichia coli-expressed chimeric VP6 protein from the EDIM strain of murine rotavirus to adult BALB/c (H-2 d) mice…”
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The role of interferons in rotavirus infections and protection by Vancott, John L, McNeal, Monica M, Choi, Anthony H C, Ward, Richard L

“…Type I and type II interferons (IFNs) play a critical role in control of a number of viral infections. To study whether altered and reduced functional…”
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Regulation of host immune responses by modification of Salmonella virulence genes by VanCott, John L, Chatfield, Stephen N, Roberts, Mark, Hone, David M, Hohmann, Elizabeth L, Pascual, David W, Yamamoto, Masafumi, Kiyono, Hiroshi, McGhee, Jerry R

“…Modifying bacterial virulence genes to probe the nature of host immunity is mostly unexplored. Here we investigate whether host immune responses can be…”
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Functional Mapping of Protective Domains and Epitopes in the Rotavirus VP6 Protein by Choi, A H, Basu, M, McNeal, M M, Flint, J, VanCott, J L, Clements, J D, Ward, R L

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The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant by Choi, Anthony H., McNeal, Monica M., Flint, Jason A., Basu, Mitali, Lycke, Nils Y., Clements, John D., Bean, Judy A., Davis, Heather L., McCluskie, Michael J., VanCott, John L., Ward, Richard L.

“…Intranasal (i.n.) immunization of BALB/c mice with chimeric murine rotavirus EDIM (epizootic diarrhea of infant mice) VP6 and attenuated E. coli heat-labile…”
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Functional mapping of protective epitopes within the rotavirus VP6 protein in mice belonging to different haplotypes by Choi, Anthony H.-C., McNeal, Monica M., Basu, Mitali, Bean, Judy A., VanCott, John L., Clements, John D., Ward, Richard L.

“…We recently used “functional mapping” to locate protective epitopes in the carboxyl terminus (aa 197–397) of the VP6 protein (designated CD) of the EDIM strain…”
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Protective Immunity to Rotavirus Shedding in the Absence of Interleukin-6: Th1 Cells and Immunoglobulin A Develop Normally by VanCott, J L, Franco, M A, Greenberg, H B, Sabbaj, S, Tang, B, Murray, R, McGhee, J R

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Mucosal immunity: Regulation by helper T cells and a novel method for detection by Jackson, Raymond J., Marinaro, Mariarosaria, VanCott, John L., Yamamoto, Masafumi, Okahashi, Nobuo, Fujihashi, Kohtaro, Kiyono, Hiroshi, Chatfield, Steven N., McGhee, Jerry R.

“…The mechanisms which regulate mucosal IgA responses to orally administered protein vaccines are not yet fully elucidated. We have used two delivery systems,…”
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Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella by VanCott, JL, Staats, HF, Pascual, DW, Roberts, M, Chatfield, SN, Yamamoto, M, Coste, M, Carter, PB, Kiyono, H, McGhee, JR

“…We have assessed regulatory Th cell and cytokine responses in mice after oral immunization with recombinant Salmonella (BRD 847) expressing fragment C of…”
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Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses by OKAHASHI, N, YAMAMOTO, M, VANCOTT, J. L, CHATFIELD, S. N, ROBERTS, M, BLUETHMANN, H, HIROI, T, KIYONO, H, MCGHEE, J. R, KAUFMANN, S. H. E

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Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice by Kweon, M N, Fujihashi, K, VanCott, J L, Higuchi, K, Yamamoto, M, McGhee, J R, Kiyono, H

“…Splenic T cells isolated from BALB/c mice that had been mucosally tolerized by oral administration of 25 mg of OVA revealed selective increases in IFN-gamma…”
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Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response by PASCUAL, D. W, HONE, D. M, KIYONO, H, MCGHEE, J. R, HALL, S, VAN GINKEL, F. W, YAMAMOTO, M, WALTERS, N, FUJIHASHI, K, POWELL, R. J, SHAOGUANG WU, VANCOTT, J. L

“…Protective immunity to enterotoxigenic Escherichia coli (ETEC) is antibody (Ab) dependent; however, oral immunization with purified ETEC fimbriae fails to…”
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Role for T cell‐independent B cell activity in the resolution of primary rotavirus infection in mice by VanCott, John L., McNeal, Monica M., Flint, Jason, Bailey, Sara A., Choi, Anthony H. C., Ward, Richard L.

“…We examined the importance of T cell‐independent B cell activity in the resolution of primary murine (EDIM) rotavirus infection in adult mice. We showed that…”
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Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon by Franco, M A, Tin, C, Rott, L S, VanCott, J L, McGhee, J R, Greenberg, H B

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The role of Th1 and Th2 cells for mucosal IgA responses by Yamamoto, M, Vancott, J L, Okahashi, N, Marinaro, M, Kiyono, H, Fujihashi, K, Jackson, R J, Chatfield, S N, Bluethmann, H, McGhee, J R

“…We have used cytokine-knockout mice to help determine the precise requirements for CD4+ Th cell regulation of IgA responses. In these studies, we have used two…”
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Role of Tumor Necrosis Factor Alpha in the Host Response of Mice to Bacteremia Caused by Pneumolysin-DeficientStreptococcus pneumoniae by Kimberly A. Benton, John L. VanCott, David E. Briles

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Role of tumor necrosis factor alpha in the host response of mice to bacteremia caused by pneumolysin-deficient Streptococcus pneumoniae by BENTON, K. A, VANCOTT, J. L, BRILES, D. E

“…Pneumolysin-deficient mutant strains of Streptococcus pneumoniae are known to cause less-severe sepsis than wild-type pneumococcal strains that produce…”
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Strategies for mucosal vaccine development by Boyaka, P N, Marinaro, M, Vancott, J L, Takahashi, I, Fujihashi, K, Yamamoto, M, van Ginkel, F W, Jackson, R J, Kiyono, H, McGhee, J R

“…Vaccines able to induce both secretory IgA for protection of mucosal surfaces and systemic immunity to pathogens invading the host are of great interest in the…”
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