Search Results - "VanAlstine, Melissa A"

Syntheses of novel high affinity ligands for opioid receptors by Wentland, Mark P., Lou, Rongliang, Lu, Qun, Bu, Yigong, Denhardt, Christoph, Jin, Jin, Ganorkar, Rakesh, VanAlstine, Melissa A., Guo, Chengyun, Cohen, Dana J., Bidlack, Jean M.

“…High binding affinity [ K i values (μ) = 0.072–1.3 nM] to opioid receptors is seen in a novel series of 3-desoxy-3-carboxamido-4-hydroxymorphinans where the…”
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Syntheses and opioid receptor binding properties of carboxamido-substituted opioids by Wentland, Mark P., Lou, Rongliang, Lu, Qun, Bu, Yigong, VanAlstine, Melissa A., Cohen, Dana J., Bidlack, Jean M.

“…A series of 15 novel opioid derivatives were made where the prototypic phenolic-OH group of traditional opioids was replaced by a carboxamido (CONH 2) group. A…”
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Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition by Yang, Jun, VanAlstine, Melissa A, Phillips, James G, Wentland, Mark P, Hough, Lindsay B

“…Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses…”
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Effects of Acetylenic Epoxygenase Inhibitors on Recombinant Cytochrome P450s by VANALSTINE, Melissa A, HOUGH, Lindsay B

“…Arachidonate epoxidation, which mediates important biological functions in several tissues, is catalyzed by specific cytochrome P450 (P450) enzymes. Two fatty…”
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Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling by Ding, Xinxin, Hough, Lindsay B, Conroy, Jennie L, Fang, Cheng, Gu, Jun, Zeitlin, Scott O, Yang, Weizhu, Yang, Jun, VanAlstine, Melissa A, Nalwalk, Julia W, Albrecht, Phillip J, Mazurkiewicz, Joseph E, Snyder-Keller, Abigail, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Behr, Melissa, Knapp, Brian I, Bidlack, Jean M, Zuiderveld, Obbe P, Leurs, Rob

“…To assess the importance of brain cytochrome P450 (P450) activity in μ opioid analgesic action, we generated a mutant mouse with brain neuron-specific…”
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Insight into the Mechanism of the Pechmann Condensation Reaction Using NMR by Tyndall, Stephen, Wong, Koon Fai, VanAlstine-Parris, Melissa A

“…The mechanism of the Pechmann condensation is still controversial despite the technological and biochemical importance of coumarins. Here, we present NMR…”
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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1′-biphenyl]-4-ylethyl) analogues of 8-CAC by Wentland, Mark P., Jo, Sunjin, Gargano, Joseph M., VanAlstine, Melissa A., Cohen, Dana J., Bidlack, Jean M.

“…N-[2-(4′-methoxy[1,1′-biphenyl]-4-yl)ethyl]-8-CAC (1) is a high affinity (Ki=0.084nM) ligand for the μ opioid receptor and served as the lead compound for this…”
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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors by VanAlstine, Melissa A., Wentland, Mark P., Alvarez, Juan, Cao, Qing, Cohen, Dana J., Knapp, Brian I., Bidlack, Jean M.

“…Derivatives of the lead compound N-BPE-8-CAC (1) where each CH of the biphenyl group was individually replaced by N were prepared in hopes of identifying high…”
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Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic by Hough, Lindsay B., Nalwalk, Julia W., Yang, Jun, Conroy, Jennie L., VanAlstine, Melissa A., Yang, Weizhu, Gargano, Joseph, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P., Phillips, James G., Knapp, Brian I., Bidlack, Jean M., Zuiderveld, Obbe P., Leurs, Rob, Ding, Xinxin

“…The search for the mechanism of action of improgan (a nonopioid analgesic) led to the recent discovery of CC12, a compound that blocks improgan…”
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Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4′-phenyl)-phenethyl) analogues of 8-CAC by VanAlstine, Melissa A., Wentland, Mark P., Cohen, Dana J., Bidlack, Jean M.

“…Novel analogues of 8-carboxamidocyclazocine have very high affinity for opioid receptors. A series of aryl-containing N-monosubstituted analogues of the lead…”
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Determining the IC50 Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver by Raymond, Lendelle, Rayani, Nikita, Polson, Grace, Sikorski, Kylie, Lian, Ailin, VanAlstine-Parris, Melissa A.

“…Vorozole and letrozole are third-generation aromatase (cytochrome P450 19A1) inhibitors. [11C]-Vorozole can be used as a radiotracer for aromatase in living…”
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Determining the IC 50 Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver by Raymond, Lendelle, Rayani, Nikita, Polson, Grace, Sikorski, Kylie, Lian, Ailin, VanAlstine-Parris, Melissa A

“…Vorozole and letrozole are third-generation aromatase (cytochrome P450 19A1) inhibitors. [(11)C]-Vorozole can be used as a radiotracer for aromatase in living…”
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Determining the IC_(50) Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver by Lendelle Raymond, Nikita Rayani, Grace Polson, Kylie Sikorski, Ailin Lian, Melissa A. VanAlstine-Parris

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Structure‐activity relationships of fragment‐based inhibitors of Trichomonas vaginalis adenosine/guanosine preferring nucleoside ribohydrolase by Emilcar, Melissa, Leonardo, Angelica, Li, Tian, Dulloo, Zaafir, Kabir, Nafeesathul Hanan, Gil, Ari, VanAlstine‐Parris, Melissa A., Stockman, Brian J.

“…Trichomoniasis is a sexually transmitted infection caused by the parasite, Trichomonas vaginalis. Infections are currently treated with 5‐nitroimidazole drugs,…”
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Brain P450 Epoxygenase Activity is Required for the Antinociceptive Effects of Improgan, a Non-Opioid Analgesic by Hough, Lindsay B., Nalwalk, Julia W., Yang, Jun, Conroy, Jennie L., VanAlstine, Melissa A., Yang, Weizhu, Gargano, Joseph, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Phillips, James G., Knapp, Brian I., Bidlack, Jean M., Zuiderveld, Obbe P., Leurs, Rob, Ding, Xinxin

“…The search for the mechanism of action of improgan (a non-opioid analgesic) led to the recent discovery of CC12, a compound which blocks improgan…”
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Determining the [IC.sub.50] values for vorozole and letrozole, on a series of human liver cytochrome P450s, to help determine the binding site of vorozole in the liver by Raymond, Lendelle, Rayani, Nikita, Polson, Grace, Sikorski, Kylie, Lian, Ailin, VanAlstine-Parris, Melissa A

“…Vorozole and letrozole are third-generation aromatase (cytochrome P450 19A1) inhibitors. [[sup.11]C]-Vorozole can be used as a radiotracer for aromatase in…”
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