Search Results - "Van der Graaf, P H"

A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models by Dua, P, Hawkins, E, van der Graaf, PH

“…Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to…”
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A Six‐Stage Workflow for Robust Application of Systems Pharmacology by Gadkar, K, Kirouac, DC, Mager, DE, van der Graaf, PH, Ramanujan, S

“…Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate…”
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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development by Milligan, P A, Brown, M J, Marchant, B, Martin, S W, van der Graaf, P H, Benson, N, Nucci, G, Nichols, D J, Boyd, R A, Mandema, J W, Krishnaswami, S, Zwillich, S, Gruben, D, Anziano, R J, Stock, T C, Lalonde, R L

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Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014) by Musuamba, FT, Manolis, E, Holford, N, Cheung, SYA, Friberg, LE, Ogungbenro, K, Posch, M, Yates, JWT, Berry, S, Thomas, N, Corriol‐Rohou, S, Bornkamp, B, Bretz, F, Hooker, AC, Van der Graaf, PH, Standing, JF, Hay, J, Cole, S, Gigante, V, Karlsson, K, Dumortier, T, Benda, N, Serone, F, Das, S, Brochot, A, Ehmann, F, Hemmings, R, Rusten, I Skottheim

“…Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of…”
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Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation by Ribba, B, Grimm, HP, Agoram, B, Davies, MR, Gadkar, K, Niederer, S, van Riel, N, Timmis, J, van der Graaf, PH

“…With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an…”
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Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models by Graaf, PH

“…CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e153; doi:10.1038/psp.2014.51; published online 22 December 2014…”
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Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study by Bakshi, S, de Lange, EC, van der Graaf, PH, Danhof, M, Peletier, LA

“…In this tutorial, we introduce basic concepts in dynamical systems analysis, such as phase‐planes, stability, and bifurcation theory, useful for dissecting the…”
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Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis by Riggs, MM, Bennetts, M, Graaf, PH, Martin, SW

“…Endometriosis is a gynecological condition resulting from proliferation of endometrial‐like tissue outside the endometrial cavity. Estrogen suppression…”
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Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology by Li, L, van der Graaf, PH

“…Examples are recent articles on a new drug combinatory effect prediction based on gene expression data by Goswami et al. ; and the medication‐wide adverse…”
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Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic‐Pharmacodynamic Behavior: An Example Using 5‐Lipoxygenase Inhibitors by Demin, O, Karelina, T, Svetlichniy, D, Metelkin, E, Speshilov, G, Demin, O, Fairman, D, Graaf, PH, Agoram, BM

“…Zileuton, a 5‐lipoxygenase (5LO) inhibitor, displays complex pharmaokinetic (PK)‐pharmacodynamic (PD) behavior. Available clinical data indicate a lack of…”
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A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain by Benson, N, Metelkin, E, Demin, O, Li, GL, Nichols, D, Graaf, PH

“…The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF‐04457845, an irreversible inhibitor of FAAH, was…”
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Systems Approaches Evolve Clinical Pharmacology by Waldman, SA, Graaf, PH, Terzic, A

“…CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e68; doi:10.1038/psp.2013.48; advance online publication 21 August 2013…”
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CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article by Graaf, PH, Friberg, LE

“…[...]the journal has now already reached the milestone of publishing its 100th manuscript, 1 which is a rare achievement for a new Open Access journal to reach…”
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What Pharmacometricians (Should) Do by Graaf, PH

“…CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e41; doi:10.1038/psp.2013.21; advance online publication 1 May 2013…”
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Regulatory Modeling and Simulation Moves Into the Next Gear in Europe by Graaf, PH

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Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions by Vicini, P, Friberg, LE, Graaf, PH, Rostami‐Hodjegan, A

“…In addition to methodological Tutorials,1 CPT:PSP has recently started to publish software Tutorials.2,3 Our readership and authors may be wondering what kind…”
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Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats by Visser, S A G, Smulders, C J G M, Reijers, B P R, Van der Graaf, P H, Peletier, L A, Danhof, M

“…The neuroactive steroid alphaxalone reveals a complex biphasic concentration-effect relationship using the 11.5 to 30 Hz frequency band of the…”
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Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors by Toni, T, Dua, P, Graaf, P H

“…The nerve growth factor (NGF) pathway has been shown to play a key role in pain treatment. Recently, a systems pharmacology model has been proposed that can…”
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Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? by Vicini, P, van der Graaf, P H

“…Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in the synergy between modeling and simulation on one hand and…”
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Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats by Visser, S A G, Huntjens, D R H, van der Graaf, P H, Peletier, L A, Danhof, M

“…The objective of the present investigation was to characterize the pharmacodynamic interaction between the synthetic neuroactive steroid alphaxalone and the…”
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