Search Results - "Van der Feen, Diederik E"

Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence by van der Feen, Diederik E, Berger, Rolf M F, Bartelds, Beatrijs

“…Cellular senescence is recognized as a crucial contributor to the pathobiology of various degenerative and cardiovascular diseases, such as idiopathic…”
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Pulmonary arterial hypertension in congenital heart disease: translational opportunities to study the reversibility of pulmonary vascular disease by van der Feen, Diederik E, Bartelds, B, de Boer, Rudolf A, Berger, Rolf M F

“…Pulmonary arterial hypertension (PAH) is a progressive and lethal pulmonary vascular disease (PVD). Although in recent years outcome has improved by new…”
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Assessment of reversibility in pulmonary arterial hypertension and congenital heart disease by van der Feen, Diederik E, Bartelds, Beatrijs, de Boer, Rudolf A, Berger, Rolf M F

“…Pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) can be reversed by early shunt closure, but this potential is lost beyond a certain…”
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Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling by Kurakula, Kondababu, Hagdorn, Quint A. J., van der Feen, Diederik E., Vonk Noordegraaf, Anton, ten Dijke, Peter, de Boer, Rudolf A., Bogaard, Harm Jan, Goumans, Marie José, Berger, Rolf M. F.

“…Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right…”
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Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension by van der Feen, Diederik E., MD, Dickinson, Michael G., MD, PhD, Bartelds, Beatrijs, MD, PhD, Borgdorff, Marinus A.J., MD, PhD, Sietsma, Hannie, MD, PhD, Lévy, Marilyne, MD, PhD, Berger, Rolf M.F., MD, PhD

“…Background Pulmonary arterial hypertension (PAH) is hallmarked by the development of neointimal lesions. The transcription factor Egr-1 seems to play a…”
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Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis by Hagdorn, Quint A J, Kurakula, Kondababu, Koop, Anne-Marie C, Bossers, Guido P L, Mavrogiannis, Emmanouil, van Leusden, Tom, van der Feen, Diederik E, de Boer, Rudolf A, Goumans, Marie-José T H, Berger, Rolf M F

“…Right ventricular (RV) function and failure are key determinants of morbidity and mortality in various cardiovascular diseases. Myocardial fibrosis is regarded…”
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Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation by Mavrogiannis, Emmanouil, Hagdorn, Quint A. J., Bazioti, Venetia, Douwes, Johannes M., Van Der Feen, Diederik E., Oberdorf‐Maass, Silke U., Westerterp, Marit, Berger, Rolf M. F.

“…Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of…”
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Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension by Van der Feen, Diederik E, Kurakula, Kondababu, Tremblay, Eve, Boucherat, Olivier, Bossers, Guido P L, Szulcek, Robert, Bourgeois, Alice, Lampron, Marie-Claude, Habbout, Karima, Martineau, Sandra, Paulin, Roxane, Kulikowski, Ewelina, Jahagirdar, Ravi, Schalij, Ingrid, Bogaard, Harm Jan, Bartelds, Beatrijs, Provencher, Steeve, Berger, Rolf M F, Bonnet, Sébastien, Goumans, Marie-José

“…Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricular (RV) failure. BRD4 (bromodomain-containing protein 4), a…”
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A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing by Hagdorn, Quint A J, Bossers, Guido P L, Koop, Anne-Marie C, Piek, Arnold, Eijgenraam, Tim R, van der Feen, Diederik E, Silljé, Herman H W, de Boer, Rudolf A, Berger, Rolf M F

“…For indexing cardiac measures in small animal models, tibia length (TL) is a recommended surrogate for body weight (BW) that aims to avoid biases because of…”
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Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure load by Bossers, Guido P.L., Günthel, Marie, van der Feen, Diederik E., Hagdorn, Quint A.J., Koop, Anne-Marie C., van Duijvenboden, Karel, Barnett, Phil, Borgdorff, Marinus A.J., Christoffels, Vincent M., Silljé, Herman H.W., Berger, Rolf M.F., Bartelds, Beatrijs

“…Right ventricular (RV) failure is a leading cause of death in patients with congenital heart disease. RV failure is kept at bay during childhood. Limited…”
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Animal models of right heart failure by Andersen, Asger, van der Feen, Diederik E., Andersen, Stine, Schultz, Jacob Gammelgaard, Hansmann, Georg, Bogaard, Harm Jan

“…Right heart failure may be the ultimate cause of death in patients with acute or chronic pulmonary hypertension (PH). As PH is often secondary to other…”
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Reply to Piquereau and Perros and to Pullamsetti and de Jesus Perez by Kurakula, Kondababu, Boucherat, Olivier, Van der Feen, Diederik E, Bogaard, Harm Jan, Kulikowski, Ewelina, Bartelds, Beatrijs, Provencher, Steeve, Berger, Rolf M F, Bonnet, Sébastien, Goumans, Marie-José

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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension by van der Feen, Diederik E, Weij, Michel, Smit-van Oosten, Annemieke, Jorna, Lysanne M, Hagdorn, Quint A J, Bartelds, Beatrijs, Berger, Rolf M F

“…In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt…”
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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension by van der Feen, Diederik E., Weij, Michel, Smit-van Oosten, Annemieke, Jorna, Lysanne M., Hagdorn, Quint A.J., Bartelds, Beatrijs, Berger, Rolf M.F.

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Abstract 16556: BRD4 Antagonist RVX208 Reverses Vascular Remodeling and Supports the Right Ventricle in Pulmonary Arterial Hypertension via PLK1 and FoxM1 by van der Feen, Diederik E, Kurakula, Kondababu, Boucherat, Olivier, Bossers, Guido P, Tremblay, Eve, Jahagirdar, Ravi, Kulikowski, Ewelina, Provencher, Steeve, Bogaard, Harm Jan, Bartelds, Beatrijs, Berger, Rolf M, Goumans, Marie-José T, Bonnet, Sébastien

“…IntroductionPulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricular (RV) failure. BMPR2 loss and DNA damage are…”
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A neonate with anaemia of prematurity: zinc protoporphyrin identifies iron deficiency anaemia without iron deficiency by van der Feen, Diederik E, van Hillegersberg, Jacqueline L A M, Schippers, Johannes A

“…Anaemia is a common problem in premature infants and is generally easy to treat with iron supplementation. If the anaemia persists despite appropriate…”
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