Search Results - "Van den Broucke, Sofie"
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Longitudinal micro-computed tomography-derived biomarkers quantify non-resolving lung fibrosis in a silicosis mouse model
Published in Scientific reports (30-09-2020)“…In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis remains a life-threatening condition for which highly…”
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Contribution of mast cells in irritant-induced airway epithelial barrier impairment in vitro
Published in Toxicology and industrial health (01-10-2020)“…The airway epithelium is continuously exposed to environmental irritants, which can cause adverse effects such as irritant-induced asthma (IIA). Mast cells are…”
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Irritant-induced asthma to hypochlorite in mice due to impairment of the airway barrier
Published in Archives of toxicology (01-04-2018)“…Inhalation of commonly present irritants, such as chlorine and chlorine derivatives, can cause adverse respiratory effects, including irritant-induced asthma…”
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Dermal exposure determines the outcome of repeated airway exposure in a long-term chemical-induced asthma-like mouse model
Published in Toxicology (Amsterdam) (01-06-2019)“…Exposure to diisocyanates is an important cause of occupational asthma (OA) in the industrialized world. Since OA occurs after long-term exposure to…”
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Effect of Graphene and Graphene Oxide on Airway Barrier and Differential Phosphorylation of Proteins in Tight and Adherens Junction Pathways
Published in Nanomaterials (Basel, Switzerland) (13-05-2021)“…Via inhalation we are continuously exposed to environmental and occupational irritants which can induce adverse health effects, such as irritant-induced asthma…”
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Involvement of Innate Lymphoid Cells and Dendritic Cells in a Mouse Model of Chemical-induced Asthma
Published in Allergy, asthma & immunology research (01-03-2021)“…Exposure to low concentrations of toluene diisocyanate (TDI) leads to immune-mediated chemical-induced asthma. The role of the adaptive immune system has…”
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Nanoparticles in the lungs of old mice: Pulmonary inflammation and oxidative stress without procoagulant effects
Published in The Science of the total environment (10-12-2018)“…Pulmonary exposure to nanoparticles (NPs) has been shown to induce pulmonary as well as cardiovascular toxicity. These effects might be enhanced in elderly…”
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Methylisothiazolinone: Dermal and respiratory immune responses in mice
Published in Toxicology letters (15-06-2015)“…•Dermal treatment with methylisothiazolinone results in sensitization.•An airway challenge with methylisothiazolinone induces sensory…”
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