Search Results - "Van de Waterbeemd, B"

Adaptive immune response to whole cell pertussis vaccine reflects vaccine quality: A possible complementation to the Pertussis Serological Potency test by Hoonakker, M.E, Verhagen, L.M, van der Maas, L, Metz, B, Uittenbogaard, J.P, van de Waterbeemd, B, van Els, C.A.C.M, van Eden, W, Hendriksen, C.F.M, Sloots, A, Han, W.G.H

“…Abstract Whole cell Bordetella pertussis (wP) vaccines are still used in many countries to protect against the respiratory disease pertussis. The potency of…”
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practical approach for exploration and modeling of the design space of a bacterial vaccine cultivation process by Streefland, M, Van Herpen, P.F.G, Van de Waterbeemd, B, Van der Pol, L.A, Beuvery, E.C, Tramper, J, Martens, D.E, Toft, M

“…A licensed pharmaceutical process is required to be executed within the validated ranges throughout the lifetime of product manufacturing. Changes to the…”
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Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process by van de Waterbeemd, Bas, Streefland, Mathieu, van der Ley, Peter, Zomer, Bert, van Dijken, Harry, Martens, Dirk, Wijffels, René, van der Pol, Leo

“…Abstract The use of detergent-extracted outer membrane vesicles (OMVs) is an established approach for development of a multivalent PorA vaccine against N…”
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Improved production process for native outer membrane vesicle vaccine against Neisseria meningitidis by van de Waterbeemd, Bas, Zomer, Gijsbert, Kaaijk, Patricia, Ruiterkamp, Nicole, Wijffels, René H, van den Dobbelsteen, Germie P J M, van der Pol, Leo A

“…An improved detergent-free process has been developed to produce vaccine based on native outer membrane vesicles (NOMV) against Neisseria meningitidis…”
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Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines by van de Waterbeemd, Bas, Mommen, Geert P. M, Pennings, Jeroen L. A, Eppink, Michel H, Wijffels, René H, van der Pol, Leo A, de Jong, Ad P. J. M

“…At present, only vaccines containing outer membrane vesicles (OMV) have successfully stopped Neisseria meningitidis serogroup B epidemics. These vaccines…”
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Identification and optimization of critical process parameters for the production of NOMV vaccine against Neisseria meningitidis by van de Waterbeemd, Bas, Streefland, Mathieu, van Keulen, Lonneke, van den IJssel, Jan, de Haan, Alex, Eppink, Michel H, van der Pol, Leo A

“…Highlights ► We optimized detergent-free OMV extraction for vaccine production. ► Two critical process parameters were identified (harvest point and extraction…”
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Unbiased Selective Isolation of Protein N-Terminal Peptides from Complex Proteome Samples Using Phospho Tagging PTAG) and TiO2-based Depletion by Mommen, G.P.M, Waterbeemd, B., van de, Meiring, H.D, Kersten, G, Heck, A.J.R, Jong, A.P.J.M., de

“…A positional proteomics strategy for global N-proteome analysis is presented based on phospho tagging (PTAG) of internal peptides followed by depletion by…”
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Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria meningitidis; implications for vaccine development by van de Waterbeemd, Bas, Zomer, Gijsbert, van den Ijssel, Jan, van Keulen, Lonneke, Eppink, Michel H, van der Ley, Peter, van der Pol, Leo A

“…Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines…”
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Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine production by van de Waterbeemd, Bas, Streefland, Mathieu, Pennings, Jeroen, van der Pol, Leo, Beuvery, Coen, Tramper, Johannes, Martens, Dirk

“…The evolution of vaccine product quality during batch cultivation of Bordetella pertussis, the causative agent of whooping cough, was investigated with the…”
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PAT for vaccines: The first stage of PAT implementation for development of a well-defined whole-cell vaccine against whooping cough disease by Streefland, Mathieu, van de Waterbeemd, Bas, Happé, Hester, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Abstract Since variation in process time and process output is commonly accepted to be inevitable for biological processes, application of Process Analytical…”
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Expression of phosphofructokinase in Neisseria meningitidis by Baart, Gino J. E, Langenhof, Marc, van de Waterbeemd, Bas, Hamstra, Hendrik-Jan, Zomer, Bert, van der Pol, Leo A, Beuvery, E. C, Tramper, Johannes, Martens, Dirk E

“…1 Netherlands Vaccine Institute (NVI), Unit Research and Development, PO Box 457, 3720 AL Bilthoven, The Netherlands 2 Wageningen University, Food and…”
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Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis by Streefland, Mathieu, van de Waterbeemd, Bas, Kint, Joeri, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Modern (bio)pharmaceutical process development requires thorough investigation of all process parameters that are critical to product quality. The impact of a…”
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Microarrays in vaccine process development: The effect of oxygen limitation on gene expression during batch cultivation of Bordetella pertussis by van de Waterbeemd, Bas, Streefland, Mathieu, Kint, Joeri, van der Pol, Leo

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