Search Results - "Van de Walle, Gerlinde R"

A Single‐Nucleotide Polymorphism in a Herpesvirus DNA Polymerase Is Sufficient to Cause Lethal Neurological Disease by Van de Walle, Gerlinde R. , Goupil, Ryan , Wishon, Cassandra , Damiani, Armando , Perkins, Gillian A. , Osterrieder, Nikolaus 

“…Epidemiological studies have shown that a single‐nucleotide polymorphism in the equid herpesvirus type 1 DNA polymerase gene is associated with outbreaks of…”
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Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds by Harman, Rebecca M, Yang, Steven, He, Megan K, Van de Walle, Gerlinde R

“…The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and…”
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Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals by Ledet, Melissa M., Harman, Rebecca M., Fan, Jennifer C., Schmitt-Matzen, Emily, Diaz-Rubio, Maria Elena, Zhang, Sheng, Van de Walle, Gerlinde R.

“…Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel…”
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Peripheral Blood‐Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model by Bussche, Leen, Van de Walle, Gerlinde R.

“…The presence of angiogenic‐stimulating factors in conditioned medium (CM) of peripheral blood‐derived equine mesenchymal stromal cells (PB‐MSCs) was examined,…”
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Tropism, pathology, and transmission of equine parvovirus-hepatitis by Tomlinson, Joy Ellen, Jager, Mason, Struzyna, Alyssa, Laverack, Melissa, Fortier, Lisa Ann, Dubovi, Edward, Foil, Lane D., Burbelo, Peter D., Divers, Thomas J., Van de Walle, Gerlinde R.

“…Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess…”
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic by Shapira, Tirosh, Monreal, I. Abrrey, Dion, Sébastien P., Buchholz, David W., Imbiakha, Brian, Olmstead, Andrea D., Jager, Mason, Désilets, Antoine, Gao, Guang, Martins, Mathias, Vandal, Thierry, Thompson, Connor A. H., Chin, Aaleigha, Rees, William D., Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, Diel, Diego G., Van de Walle, Gerlinde R., August, Avery, Whittaker, Gary R., Boudreault, Pierre-Luc, Leduc, Richard, Aguilar, Hector C., Jean, François

“…The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their…”
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Identification and Characterization of Equine Herpesvirus Type 1 pUL56 and Its Role in Virus-Induced Downregulation of Major Histocompatibility Complex Class I by Ma, Guanggang, Feineis, Silke, Osterrieder, Nikolaus, Van de Walle, Gerlinde R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Electric Cell-Substrate Impedance Sensing To Monitor Viral Growth and Study Cellular Responses to Infection with Alphaherpesviruses in Real Time by Pennington, Matthew R, Van de Walle, Gerlinde R

“…Electric cell-substrate impedance sensing (ECIS) measures changes in an electrical circuit formed in a culture dish. As cells grow over a gold electrode, they…”
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Bovine milk-derived cells express transcriptome markers of pluripotency and secrete bioactive factors with regenerative and antimicrobial activity by Danev, Nikola, Harman, Rebecca M., Oliveira, Leane, Huntimer, Lucas, Van de Walle, Gerlinde R.

“…The bovine mammary stem/progenitor cell secretome stimulates regeneration in vitro and contains proteins associated with antimicrobial defense. This has led to…”
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Nasal transmission of equine parvovirus hepatitis by Tomlinson, Joy E., Van de Walle, Gerlinde R.

“…Background Equine parvovirus hepatitis (EqPV‐H) is highly prevalent and causes subclinical to fatal hepatitis, which can occur in outbreaks. Whereas iatrogenic…”
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The mesenchymal stromal cell secretome impairs methicillin‐resistant Staphylococcus aureus biofilms via cysteine protease activity in the equine model by Marx, Charlotte, Gardner, Sophia, Harman, Rebecca M., Van de Walle, Gerlinde R.

“…Mesenchymal stromal cells (MSCs) from various species, such as humans, mice, and horses, were recently found to effectively inhibit the growth of various…”
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Small but mighty: old and new parvoviruses of veterinary significance by Jager, Mason C, Tomlinson, Joy E, Lopez-Astacio, Robert A, Parrish, Colin R, Van de Walle, Gerlinde R

“…In line with the Latin expression "sed parva forti" meaning "small but mighty," the family Parvoviridae contains many of the smallest known viruses, some of…”
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Mesenchymal stromal cell‐secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes by Marx, Charlotte, Gardner, Sophia, Harman, Rebecca M., Wagner, Bettina, Van de Walle, Gerlinde R.

“…Mesenchymal stromal cells (MSCs) from both humans and horses, which represent a clinically relevant translation animal model for human cutaneous wound healing,…”
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Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet + B cells by Patel, Roosheel S, Tomlinson, Joy E, Divers, Thomas J, Van de Walle, Gerlinde R, Rosenberg, Brad R

“…Traditional laboratory model organisms represent a small fraction of the diversity of multicellular life, and findings in any given experimental model often do…”
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Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection by Tomlinson, Joy E., Wolfisberg, Raphael, Fahnøe, Ulrik, Patel, Roosheel S., Trivedi, Sheetal, Kumar, Arvind, Sharma, Himanshu, Nielsen, Louise, McDonough, Sean P., Bukh, Jens, Tennant, Bud C., Kapoor, Amit, Rosenberg, Brad R., Rice, Charles M., Divers, Thomas J., Van de Walle, Gerlinde R., Scheel, Troels K.H.

“…Background and Aims Equine hepacivirus (EqHV) is phylogenetically the closest relative of HCV and shares genome organization, hepatotropism, transient or…”
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Preliminary in vivo investigation of the mesenchymal stromal cell secretome as a novel treatment for methicillin‐resistant Staphylococcus aureus in equine skin wounds by Fahey, Megan J., Harman, Rebecca M., Thomas, Matthew A., Pugliese, Brenna R., Peters‐Kennedy, Jeanine, Delco, Michelle L., Van de Walle, Gerlinde R.

“…Objective We aimed to study the antimicrobial and pro‐healing potential of equine mesenchymal stromal cell secreted products (i.e. secretome), collected as…”
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Beyond tradition and convention: benefits of non-traditional model organisms in cancer research by Harman, Rebecca M., Das, Sanjna P., Bartlett, Arianna P., Rauner, Gat, Donahue, Leanne R., Van de Walle, Gerlinde R.

“…Traditional laboratory model organisms are indispensable for cancer research and have provided insight into numerous mechanisms that contribute to cancer…”
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Characterization of nonprimate hepacivirus and construction of a functional molecular clone by Scheel, Troels K. H., Kapoor, Amit, Nishiuchi, Eiko, Brock, Kenny V., Yu, Yingpu, Andrus, Linda, Gu, Meigang, Renshaw, Randall W., Dubovi, Edward J., McDonough, Sean P., Van de Walle, Gerlinde R., Lipkin, W. Ian, Divers, Thomas J., Tennant, Bud C., Rice, Charles M.

“…Nonprimate hepacivirus (NPHV) is the closest known relative of hepatitis C virus (HCV) and its study could enrich our understanding of HCV evolution, immunity,…”
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Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility by Harman, Rebecca M, Patel, Roosheel S, Fan, Jennifer C, Park, Jee E, Rosenberg, Brad R, Van de Walle, Gerlinde R

“…The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue…”
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The mammosphere-derived epithelial cell secretome modulates neutrophil functions in the bovine model by Harman, Rebecca M, Sipka, Anja, Oxford, Kelly A, Oliveira, Leane, Huntimer, Lucas, Nydam, Daryl V, Van de Walle, Gerlinde R

“…Innovative therapies against bacterial infections are needed. One approach is to focus on host-directed immunotherapy (HDT), with treatments that exploit…”
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