Search Results - "Van de Kar, L D"

Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder by Lee, Royce, Ferris, Craig, Van de Kar, L.D, Coccaro, Emil F

“…Summary Background Data from animal studies have identified oxytocin as an important modulator of social aggression. We have previously reported on a…”
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Serotonin and the Neuroendocrine Regulation of the Hypothalamic–Pituitary–Adrenal Axis in Health and Disease by Sullivan Hanley, N.R, Van de Kar, L.D

“…Serotonin (5-hydroxytryptamine, 5-HT)-containing neurons in the midbrain directly innervate corticotropin-releasing hormone (CRH)-containing cells located in…”
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Chronic olanzapine activates the Stat3 signal transduction pathway and alters expression of components of the 5-HT2A receptor signaling system in rat frontal cortex by Muma, N A, Singh, R K, Vercillo, M S, D'Souza, D N, Zemaitaitis, B, Garcia, F, Damjanoska, K J, Zhang, Y, Battaglia, G, Van de Kar, L D

“…The mechanisms underlying desensitization of serotonin 2A (5-HT(2A)) receptor signaling by antagonists are unclear but may involve changes in gene expression…”
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Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon by CARRASCO, G. A, VAN DE KAR, L. D, SULLIVAN, N. R, LANDRY, M, GARCIA, F, MUMA, N. A, BATTAGLIA, G

“…We previously reported that treatment and withdrawal from cocaine increases: (1) 5-HT2A receptor-mediated neuroendocrine responses, and (2) Galphaq and…”
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Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet by D'Souza, D N, Zhang, Y, Garcia, F, Battaglia, G, Van de Kar, L D

“…Tryptophan depleting protocols are commonly used to study the role of serotonin in mood disorders. The present study examined the impact of a…”
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Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1 and Gαz by Creech, R.D., Li, Q., Carrasco, G.A., Van de Kar, L.D., Muma, N.A.

“…Hyperactivity of hypothalamic–pituitary mediated hormone responses, such as to stimulation with a serotonin 1A (5-HT1A) receptor agonist, are a feature of…”
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Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI) by Li, Q, Brownfield, M S, Battaglia, G, Cabrera, T M, Levy, A D, Rittenhouse, P A, van de Kar, L D

“…Various endocrine responses to 5-hydroxytryptamine (serotonin, 5-HT) agonists were used to assess serotonergic receptor function after chronic treatment with…”
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Agonist-induced serotonin 2A receptor desensitization in the rat frontal cortex and hypothalamus by Damjanoska, K J, Heidenreich, B A, Kindel, G H, D'Souza, D N, Zhang, Y, Garcia, F, Battaglia, G, Wolf, W A, Van de Kar, L D, Muma, N A

“…This study examined the time course and possible mechanisms of agonist-induced desensitization of 5-hydroxytryptamine serotonin 2A receptors in the rat frontal…”
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Enhanced serotonergic transmission stimulates oxytocin secretion in conscious male rats by Saydoff, J A, Rittenhouse, P A, van de Kar, L D, Brownfield, M S

“…The involvement of serotonin (5-HT) in oxytocin secretion was investigated in this study. Pharmacologic agents that influence serotonergic transmission were…”
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Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: Possible role in desensitization of 5-hydroxytryptamine1A receptors by CARRASCO, G. A, BARKER, S. A, ZHANG, Y, DAMJANOSKA, K. J, SULLIVAN, N. R, GARCIA, F, D'SOUZA, D. N, MUMA, N. A, VAN DE KAR, L. D

“…Desensitization of post-synaptic serotonin1A (5-HT1A) receptors may underlie the clinical improvement of neuropsychiatric disorders. In the hypothalamic…”
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Neuroendocrine evidence for denervation supersensitivity of serotonin receptors: effects of the 5-HT agonist RU 24969 on corticotropin, corticosterone, prolactin and renin secretion by Van de Kar, L D, Carnes, M, Maslowski, R J, Bonadonna, A M, Rittenhouse, P A, Kunimoto, K, Piechowski, R A, Bethea, C L

“…Serotonergic stimulation can increase the secretion of several hormones through the involvement of different serotonin (5-HT) receptor subtypes. RU 24969, a…”
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Cocaine-induced elevation of plasma adrenocorticotropin hormone and corticosterone is mediated by serotonergic neurons by Levy, A D, Li, Q A, Kerr, J E, Rittenhouse, P A, Milonas, G, Cabrera, T M, Battaglia, G, Alvarez Sanz, M C, Van de Kar, L D

“…We investigated the hypothesis that cocaine-induced elevations of plasma adrenocorticotropin hormone (ACTH) and corticosterone are mediated by brain serotonin…”
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Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects by NEWMAN, M. E, LI, Q, GELFIN, Y, VAN DE KAR, L. D, LERER, B

“…The present study investigated whether administration of a 5-HT1A receptor agonist would increase growth hormone (GH) and oxytocin levels in normal human…”
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Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats by Zhang, Yahong, Raap, Danı́ K, Garcia, Francisca, Serres, Florence, Ma, Qing, Battaglia, George, Van de Kar, Louis D

“…The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors…”
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WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretion by Vicentic, Aleksandra, Li, Qian, Battaglia, George, Van de Kar, Louis D

“…Previous studies suggest that the 5-HT 1A receptor agonist 8-hydroxy-2-(di- n-propylamino) tetralin (8-OH-DPAT) increases the secretion of oxytocin,…”
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Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors by Rittenhouse, P A, Bakkum, E A, Van de Kar, L D

“…DOI [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCI] is a serotonin (5-HT1C/5-HT2) agonist, with potent cardiovascular effects. The purpose of the…”
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Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by β antagonists by Richardson Morton, K.D., Johnson, M.D., Van de Kar, L.D.

“…The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of…”
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d-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala by Javed, A., Kamradt, M.C., Van de Kar, L.D., Gray, T.S.

“…The neurotransmitters expressed by neurons activated by d-fenfluramine (5 mg/kg, i.p.) were identified in the hypothalamus, amygdala and bed nucleus of the…”
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Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT1A receptors by D'SOUZA, D. N, ZHANG, Y, GARCIA, F, BATTAGLIA, G, VAN DE KAR, L. D

“…Abstract Rationale. Selective serotonin (5-HT, 5-hydroxytryptamine) reuptake inhibitors (SSRIs) such as fluoxetine produce a gradual desensitization of…”
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5-HT2A Receptors Stimulate ACTH, Corticosterone, Oxytocin, Renin, and Prolactin Release and Activate Hypothalamic CRF and Oxytocin-Expressing Cells by Van de Kar, Louis D, Javed, Adil, Zhang, Yahong, Serres, Florence, Raap, Dani K, Gray, Thackery S

“…The 5-HT(2A/2C) agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI) stimulates hypothalamic neurons to increase the secretion of several…”
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