Search Results - "Van de Bittner, Genevieve C."

Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems by Lippert, Alexander R, Van de Bittner, Genevieve C, Chang, Christopher J

“…Reactive oxygen species (ROS), such as hydrogen peroxide, are important products of oxygen metabolism that, when misregulated, can accumulate and cause…”
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Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation by Van de Bittner, Genevieve C, Bertozzi, Carolyn R, Chang, Christopher J

“…In vivo molecular imaging holds promise for understanding the underlying mechanisms of health, injury, aging, and disease, as it can detect distinct…”
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In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease by Heffern, Marie C., Park, Hyo Min, Au-Yeung, Ho Yu, Van de Bittner, Genevieve C., Ackerman, Cheri M., Stahl, Andreas, Chang, Christopher J.

“…Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic…”
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Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model by Hirayama, Tasuku, Van de Bittner, Genevieve C., Gray, Lawrence W., Lutsenko, Svetlana, Chang, Christopher J.

“…Copper is an essential metal nutrient that is tightly regulated in the body because loss of its homeostasis is connected to severe diseases such as Menkes and…”
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Development of a Fluorinated Class‑I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance by Strebl, Martin G, Wang, Changning, Schroeder, Frederick A, Placzek, Michael S, Wey, Hsiao-Ying, Van de Bittner, Genevieve C, Neelamegam, Ramesh, Hooker, Jacob M

“…Despite major efforts, our knowledge about many brain diseases remains remarkably limited. Epigenetic dysregulation has been one of the few leads toward…”
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In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter by Van de Bittner, Genevieve C., Dubikovskaya, Elena A., Bertozzi, Carolyn R., Chang, Christopher J., Neckers, Doug

“…Living organisms produce hydrogen peroxide (H₂O₂) to kill invading pathogens and for cellular signaling, but aberrant generation of this reactive oxygen…”
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In Vivo Metal Ion Imaging Using Fluorescent Sensors by Van de Bittner, Genevieve C, Hirayama, Tasuku

“…In vivo imaging in living animals provides the ability to monitor alterations of signaling molecules, ions, and other biological components during various life…”
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Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A by Van de Bittner, Genevieve C, Van de Bittner, Kyle C, Wey, Hsiao-Ying, Rowe, Wayne, Dharanipragada, Ram, Ying, Xiaoyou, Hurst, William, Giovanni, Andrew, Alving, Kim, Gupta, Anurag, Hoekman, John, Hooker, Jacob M

“…Intranasal drug delivery is a noninvasive drug delivery route that can enhance systemic delivery of therapeutics with poor oral bioavailability by exploiting…”
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A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography by Wang, Changning, Placzek, Michael S, Van de Bittner, Genevieve C, Schroeder, Frederick A, Hooker, Jacob M

“…Monoacylglycerol lipase (MAGL) is a serine hydrolase that hydrolyzes monoacylglycerols to glycerol and fatty acid and plays an important role in…”
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A Chemical Strategy for the Cell-Based Detection of HDAC Activity by Diyabalanage, Himashinie V. K, Van de Bittner, Genevieve C, Ricq, Emily L, Hooker, Jacob M

“…A strategy for activity-based enzyme detection using a novel enamide-based chemical strategy is described. Enzymatic cleavage of an amide bond results in the…”
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A Philosophy for CNS Radiotracer Design by Van de Bittner, Genevieve C, Ricq, Emily L, Hooker, Jacob M

“…Decades after its discovery, positron emission tomography (PET) remains the premier tool for imaging neurochemistry in living humans. Technological…”
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Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET by Placzek, Michael S, Van de Bittner, Genevieve C, Wey, Hsiao-Ying, Lukas, Scott E, Hooker, Jacob M

“…Monitoring changes in opioid receptor binding with positron emission tomography (PET) could lead to a better understanding of tolerance and addiction because…”
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Functionally Biased D2R Antagonists: Targeting the β‑Arrestin Pathway to Improve Antipsychotic Treatment by Weïwer, Michel, Xu, Qihong, Gale, Jennifer P, Lewis, Michael, Campbell, Arthur J, Schroeder, Frederick A, Van de Bittner, Genevieve C, Walk, Michelle, Amaya, Aldo, Su, Ping, D̵ordevic, Luka, Sacher, Joshua R, Skepner, Adam, Fei, David, Dennehy, Kelly, Nguyen, Shannon, Faloon, Patrick W, Perez, Jose, Cottrell, Jeffrey R, Liu, Fang, Palmer, Michelle, Pan, Jen Q, Hooker, Jacob M, Zhang, Yan-Ling, Scolnick, Edward, Wagner, Florence F, Holson, Edward B

“…Schizophrenia is a severe neuropsychiatric disease that lacks completely effective and safe therapies. As a polygenic disorder, genetic studies have only…”
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Nasal neuron PET imaging quantifies neuron generation and degeneration by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Herrick, Scott P, Ricq, Emily L, Wey, Hsiao-Ying, O'Neill, Michael J, Ahmed, Zeshan, Murray, Tracey K, Smith, Jaclyn E, Wang, Changning, Schroeder, Frederick A, Albers, Mark W, Hooker, Jacob M

“…Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy…”
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Immediate and persistent effects of Salvinorin A on the kappa opioid receptor in rodents, monitored in vivo with pet by Placzek, Michael S, Van de Bittner, Genevieve C, Wey, Hsiao-Ying, Lukas, Scott E, Hooker, Jacob M

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OLFACTORY SENSORY NEURON MONITORING IN ALZHEIMER’S DISEASE: TOWARD HUMAN TRANSLATION OF A PET IMAGING AGENT by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M, Wey, Hsiao-Ying

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OLFACTORY SENSORY NEURON MONITORING IN ALZHEIMER’S DISEASE: TOWARD HUMAN TRANSLATION OF A PET IMAGING AGENT by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Wey, Hsiao-Ying, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M

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O1‐06‐06: Olfactory Sensory Neuron Monitoring in Alzheimer’s Disease: Toward Human Translation of a Pet Imaging Agent by Van de Bittner, Genevieve C., Riley, Misha M., Cao, Luxiang, Ehses, Janina, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M., Wey, Hsiao-Ying

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IC‐P‐166: Olfactory Sensory Neuron Monitoring in Alzheimer’s Disease: Toward Human Translation of a Pet Imaging Agent by Van de Bittner, Genevieve C., Riley, Misha M., Cao, Luxiang, Ehses, Janina, Wey, Hsiao-Ying, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M.

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