Search Results - "Van de Berg, Wilma D. J."

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease by Moors, Tim E., Hoozemans, Jeroen J. M., Ingrassia, Angela, Beccari, Tommaso, Parnetti, Lucilla, Chartier-Harlin, Marie-Christine, van de Berg, Wilma D. J.

“…Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson's…”
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Allele-specific expression of Parkinson’s disease susceptibility genes in human brain by Langmyhr, Margrete, Henriksen, Sandra Pilar, Cappelletti, Chiara, van de Berg, Wilma D. J., Pihlstrøm, Lasse, Toft, Mathias

“…Genome-wide association studies have identified genetic variation in genomic loci associated with susceptibility to Parkinson’s disease (PD), the most common…”
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Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson's Disease by Hepp, Dagmar H, van Wageningen, Thecla A, Kuiper, Kirsten L, van Dijk, Karin D, Oosterveld, Linda P, Berendse, Henk W, van de Berg, Wilma D J

“…An altered immune response has been identified as a pathophysiological factor in Parkinson's disease (PD). We aimed to identify blood immunity-associated…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain by van den Berge, Simone A., van Strien, Miriam E., Korecka, Joanna A., Dijkstra, Anke A., Sluijs, Jacqueline A., Kooijman, Lieneke, Eggers, Ruben, De Filippis, Lidia, Vescovi, Angelo L., Verhaagen, Joost, van de Berg, Wilma D. J., Hol, Elly M.

“…There are many indications that neurogenesis is impaired in Parkinson's disease, which might be due to a lack of dopamine in the subventricular zone. An…”
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Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease by Dijkstra, Anke A, Ingrassia, Angela, de Menezes, Renee X, van Kesteren, Ronald E, Rozemuller, Annemieke J M, Heutink, Peter, van de Berg, Wilma D J

“…Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson's disease (PD). To elucidate molecular mechanisms underlying…”
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Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease by Majbour, Nour K, Vaikath, Nishant N, van Dijk, Karin D, Ardah, Mustafa T, Varghese, Shiji, Vesterager, Louise B, Montezinho, Liliana P, Poole, Stephen, Safieh-Garabedian, Bared, Tokuda, Takahiko, Teunissen, Charlotte E, Berendse, Henk W, van de Berg, Wilma D J, El-Agnaf, Omar M A

“…Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson's disease (PD) based on biochemical analysis of blood or CSF…”
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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology by Pihlstrøm, Lasse, Shireby, Gemma, Geut, Hanneke, Henriksen, Sandra Pilar, Rozemuller, Annemieke J. M., Tunold, Jon-Anders, Hannon, Eilis, Francis, Paul, Thomas, Alan J., Love, Seth, Mill, Jonathan, van de Berg, Wilma D. J., Toft, Mathias

“…Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy,…”
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A comprehensive analysis of SNCA‐related genetic risk in sporadic parkinson disease by Pihlstrøm, Lasse, Blauwendraat, Cornelis, Cappelletti, Chiara, Berge‐Seidl, Victoria, Langmyhr, Margrete, Henriksen, Sandra Pilar, van de Berg, Wilma D. J., Gibbs, J. Raphael, Cookson, Mark R., Singleton, Andrew B., Nalls, Mike A., Toft, Mathias

“…Objective The goal of this study was to refine our understanding of disease risk attributable to common genetic variation in SNCA, a major locus in Parkinson…”
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Regional differences in synaptic degeneration are linked to alpha-synuclein burden and axonal damage in Parkinson's disease and dementia with Lewy bodies by Frigerio, Irene, Bouwman, Maud M A, Noordermeer, Ruby T G M M, Podobnik, Ema, Popovic, Marko, Timmermans, Evelien, Rozemuller, Annemieke J M, van de Berg, Wilma D J, Jonkman, Laura E

“…Regional differences in synaptic degeneration may underlie differences in clinical presentation and neuropathological disease progression in Parkinson's…”
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CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers by Majbour, Nour K, Aasly, Jan O, Hustad, Eldbjørg, Thomas, Mercy A, Vaikath, Nishant N, Elkum, Naser, van de Berg, Wilma D J, Tokuda, Takahiko, Mollenhauer, Brit, Berendse, Henk W, El-Agnaf, Omar M A

“…Asymptomatic carriers of leucine-rich repeat kinase 2 (LRRK2) gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson's…”
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Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies by Fathy, Yasmine Y, Jonkman, Laura E, Bol, John J, Timmermans, Evelien, Jonker, Allert J, Rozemuller, Annemieke J M, van de Berg, Wilma D J

“…Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson's disease (PD) and…”
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Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson's disease dementia by Frigerio, Irene, Laansma, Max A, Lin, Chen-Pei, Hermans, Emma J M, Bouwman, Maud M A, Bol, John G J M, Galis-de Graaf, Yvon, Hepp, Dagmar H, Rozemuller, Annemieke J M, Barkhof, Frederik, van de Berg, Wilma D J, Jonkman, Laura E

“…Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed…”
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Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease by Donega, Vanessa, Burm, Saskia M, van Strien, Miriam E, van Bodegraven, Emma J, Paliukhovich, Iryna, Geut, Hanneke, van de Berg, Wilma D J, Li, Ka Wan, Smit, August B, Basak, Onur, Hol, Elly M

“…It is currently accepted that the human brain has a limited neurogenic capacity and an impaired regenerative potential. We have previously shown the existence…”
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies by Moors, Tim E, Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N, Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D J, Britschgi, Markus

“…Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated…”
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Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis by Fathy, Yasmine Y., Hoogers, Susanne E., Berendse, Henk W., van der Werf, Ysbrand D., Visser, Pieter J., de Jong, Frank J., van de Berg, Wilma D.J.

“…The insular cortex is proposed to function as a central brain hub characterized by wide-spread connections and diverse functional roles. As a result, its…”
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Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease by Lin, Chen-Pei, Frigerio, Irene, Bol, John G J M, Bouwman, Maud M A, Wesseling, Alex J, Dahl, Martin J, Rozemuller, Annemieke J M, van der Werf, Ysbrand D, Pouwels, Petra J W, van de Berg, Wilma D J, Jonkman, Laura E

“…Degeneration of the locus coeruleus (LC) noradrenergic system contributes to clinical symptoms in Alzheimer's disease (AD) and Parkinson's disease (PD)…”
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Author Correction: Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention by Obermayer, Joshua, Luchicchi, Antonio, Heistek, Tim S., de Kloet, Sybren F., Terra, Huub, Bruinsma, Bastiaan, Mnie-Filali, Ouissame, Kortleven, Christian, Galakhova, Anna A., Khalil, Ayoub J., Kroon, Tim, Jonker, Allert J., de Haan, Roel, van de Berg, Wilma D. J., Goriounova, Natalia A., de Kock, Christiaan P. J., Pattij, Tommy, Mansvelder, Huibert D.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Toll-like Receptor 4 Is Upregulated in Parkinson's Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology by Conte, Carmela, Ingrassia, Angela, Breve, John, Bol, John J, Timmermans-Huisman, Evelien, van Dam, Anne-Marie, Beccari, Tommaso, van de Berg, Wilma D J

“…Growing evidence suggests a crucial role of neuroinflammation in the pathophysiology of Parkinson's disease (PD). Neuroinflammation is linked to the…”
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Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies by Chatterjee, Madhurima, van Steenoven, Inger, Huisman, Evelien, Oosterveld, Linda, Berendse, Henk, van der Flier, Wiesje M, Del Campo, Marta, Lemstra, Afina W, van de Berg, Wilma D J, Teunissen, Charlotte E

“…Synaptic degeneration is an early phenomenon in Parkinson's disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1…”
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