Search Results - "Van Wyk, Michiel"

A visual opsin from jellyfish enables precise temporal control of G protein signalling by van Wyk, Michiel, Kleinlogel, Sonja

“…Phototransduction is mediated by distinct types of G protein cascades in different animal taxa: bilateral invertebrates typically utilise the Gαq pathway…”
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Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool by van Wyk, Michiel, Pielecka-Fortuna, Justyna, Löwel, Siegrid, Kleinlogel, Sonja

“…Photoreceptor degeneration is one of the most prevalent causes of blindness. Despite photoreceptor loss, the inner retina and central visual pathways remain…”
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Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina by Kralik, Jakub, van Wyk, Michiel, Stocker, Nino, Kleinlogel, Sonja

“…Optogenetic gene therapies to restore vision are in clinical trials. Whilst current clinical approaches target the ganglion cells, the output neurons of the…”
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A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation by Goldmann, Tobias, Overlack, Nora, Möller, Fabian, Belakhov, Valery, van Wyk, Michiel, Baasov, Timor, Wolfrum, Uwe, Nagel‐Wolfrum, Kerstin

“…Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic…”
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Local Edge Detectors: A Substrate for Fine Spatial Vision at Low Temporal Frequencies in Rabbit Retina by van Wyk, Michiel, Taylor, W. Rowland, Vaney, David I

“…Visual acuity is limited by the size and density of the smallest retinal ganglion cells, which correspond to the midget ganglion cells in primate retina and…”
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Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina by Venkataramani, Sowmya, Van Wyk, Michiel, Buldyrev, Ilya, Sivyer, Benjamin, Vaney, David I, Taylor, W Rowland

“…This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We…”
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Synaptic inputs and timing underlying the velocity tuning of direction‐selective ganglion cells in rabbit retina by Sivyer, Benjamin, Van Wyk, Michiel, Vaney, David I., Taylor, W. Rowland

“…There are two types of direction‐selective ganglion cells (DSGCs) identified in the rabbit retina, which can be readily distinguished both morphologically and…”
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The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience by Kralik, Jakub, van Wyk, Michiel, Leonardon, Benjamin, Schilardi, Giulia, Schneider, Sabine, Kleinlogel, Sonja

“…PurposeThe isolated ex vivo retina is the standard model in retinal physiology and neuroscience. During isolation, the retina is peeled from the retinal…”
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Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice by van Wyk, Michiel, Schneider, Sabine, Kleinlogel, Sonja

“…Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical…”
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Receptive field properties of ON- and OFF-ganglion cells in the mouse retina by van Wyk, Michiel, Wässle, Heinz, Taylor, W Rowland

“…There are two subclasses of alpha cell in the mammalian retina, which are morphologically identical in plain view but have opposite responses to a luminance…”
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Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells by Thyagarajan, Senthil, van Wyk, Michiel, Lehmann, Konrad, Löwel, Siegrid, Feng, Guoping, Wässle, Heinz

“…The progression of rod and cone degeneration in retinally degenerate (rd) mice ultimately results in a complete loss of photoreceptors and blindness. The inner…”
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Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool: e1002143 by Wyk, Michiel van, Pielecka-Fortuna, Justyna, Löwel, Siegrid, Kleinlogel, Sonja

“…Photoreceptor degeneration is one of the most prevalent causes of blindness. Despite photoreceptor loss, the inner retina and central visual pathways remain…”
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Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy by van Wyk, Michiel, Hulliger, Elmar C, Girod, Lara, Ebneter, Andreas, Kleinlogel, Sonja

“…Recent studies have demonstrated the safety and efficacy of ocular gene therapy based on adeno-associated viral vectors (AAVs). Accordingly, a surge in…”
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Synaptic inputs and timing underlying the velocity tuning of direction-selective ganglion cells in rabbit retina: Velocity tuning of direction-selective ganglion cells by Sivyer, Benjamin, Van Wyk, Michiel, Vaney, David I., Taylor, W. Rowland

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Dendritic Projections and Dye-Coupling in Dopaminergic Neurons of the Substantia Nigra Examined in Horizontal Brain Slices From Young Rats by Lin, John Y, van Wyk, Michiel, Bowala, Tharushini K, Teo, Min-Yau, Lipski, Janusz

“…Division of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, Private Bag 92-019 New Zealand Submitted 10 January 2003;…”
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The network vs. pacemaker theory of the activity of RVL presympathetic neurons-a comparison with another putative pacemaker system by Lipski, Janusz, Lin, John, Teo, Min-Yau, van Wyk, Michiel

“…Intracellular studies previously conducted in our laboratory on adult rats indicate that the activity of spinally projecting RVL neurons (neurons located in…”
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Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro by Teo, Min-Yau, van Wyk, Michiel, Lin, John, Lipski, Janusz

“…Despite resembling each other in many respects, dopaminergic neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) exhibit…”
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