Search Results - "Van Woerden, Geeske M"

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility by Judson, Matthew C., Wallace, Michael L., Sidorov, Michael S., Burette, Alain C., Gu, Bin, van Woerden, Geeske M., King, Ian F., Han, Ji Eun, Zylka, Mark J., Elgersma, Ype, Weinberg, Richard J., Philpot, Benjamin D.

“…Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic…”
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Non-associative potentiation of perisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons by Lourenço, Joana, Pacioni, Simone, Rebola, Nelson, van Woerden, Geeske M, Marinelli, Silvia, DiGregorio, David, Bacci, Alberto

“…In the neocortex, the coexistence of temporally locked excitation and inhibition governs complex network activity underlying cognitive functions, and is…”
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The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes by Vargas, Jessica Y, Loria, Frida, Wu, Yuan‐Ju, Córdova, Gonzalo, Nonaka, Takashi, Bellow, Sebastien, Syan, Sylvie, Hasegawa, Masato, van Woerden, Geeske M, Trollet, Capucine, Zurzolo, Chiara

“…Tunneling nanotubes (TNTs) are actin‐based transient tubular connections that allow direct communication between distant cells. TNTs play an important role in…”
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CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles by Moro, Alessandro, van Woerden, Geeske M, Toonen, Ruud F, Verhage, Matthijs

“…Ca2+/calmodulin-dependent kinase II (CaMKII) regulates synaptic plasticity in multiple ways, supposedly including the secretion of neuromodulators like…”
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A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants by Sonzogni, Monica, Wallaard, Ilse, Santos, Sara Silva, Kingma, Jenina, du Mee, Dorine, van Woerden, Geeske M, Elgersma, Ype

“…Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired…”
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RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity by Proietti Onori, Martina, Koene, Linda M. C, Schäfer, Carmen B, Nellist, Mark, de Brito van Velze, Marcel, Gao, Zhenyu, Elgersma, Ype, van Woerden, Geeske M

“…Hyperactivation of the mammalian target of rapamycin (mTOR) pathway can cause malformation of cortical development (MCD) with associated epilepsy and…”
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Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior by Rigter, Pomme M F, de Konink, Charlotte, van Woerden, Geeske M

“…The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental…”
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Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures by Goorden, Susanna M. I., van Woerden, Geeske M., van der Weerd, Louise, Cheadle, Jeremy P., Elgersma, Ype

“…Objective Tuberous sclerosis complex (TSC) is characterized by brain lesions, epilepsy, increased incidence of mental retardation and autism. The causal link…”
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Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome by Sonzogni, Monica, Zhai, Peipei, Mientjes, Edwin J, van Woerden, Geeske M, Elgersma, Ype

“…Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by the loss of functional ubiquitin protein ligase E3A (UBE3A). In…”
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Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes by Sonzogni, Monica, Hakonen, Johanna, Bernabé Kleijn, Mireia, Silva-Santos, Sara, Judson, Matthew C, Philpot, Benjamin D, van Woerden, Geeske M, Elgersma, Ype

“…Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting gene expression. Previous studies in mice revealed distinct…”
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The intellectual disability‐associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain‐of‐function by Proietti Onori, Martina, Koopal, Balwina, Everman, David B., Worthington, Jessica D., Jones, Julie R., Ploeg, Melissa A., Mientjes, Edwin, Bon, Bregje W., Kleefstra, Tjitske, Schulman, Howard, Kushner, Steven A., Küry, Sébastien, Elgersma, Ype, Woerden, Geeske M.

“…The abundantly expressed calcium/calmodulin‐dependent protein kinase II (CAMK2), alpha (CAMK2A), and beta (CAMK2B) isoforms are essential for learning and…”
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Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome by Wang, Tiantian, van Woerden, Geeske M, Elgersma, Ype, Borst, J Gerard G

“…The neurodevelopmental disorder Angelman syndrome (AS) is characterized by intellectual disability, motor dysfunction, distinct behavioral aspects, and…”
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Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model by Bruinsma, Caroline F, Schonewille, Martijn, Gao, Zhenyu, Aronica, Eleonora M A, Judson, Matthew C, Philpot, Benjamin D, Hoebeek, Freek E, van Woerden, Geeske M, De Zeeuw, Chris I, Elgersma, Ype

“…Angelman syndrome (AS) is a severe neurological disorder that is associated with prominent movement and balance impairments that are widely considered to be…”
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Case Report: Developmental Delay and Acute Neuropsychiatric Episodes Associated With a de novo Mutation in the CAMK2B Gene (c.328G>A p.Glu110Lys) by Dwyer, Bonnie K, Veenma, Danielle C M, Chang, Kiki, Schulman, Howard, Van Woerden, Geeske M

“…Mutations in the genes encoding calcium/calmodulin dependent protein kinase II (CAMK2) isoforms cause a newly recognized neurodevelopmental disorder (ND), for…”
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The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons by Tonazzini, Ilaria, Van Woerden, Geeske M, Masciullo, Cecilia, Mientjes, Edwin J, Elgersma, Ype, Cecchini, Marco

“…Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in…”
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Rheb Is Essential for Murine Development by Goorden, Susanna M. I., Hoogeveen-Westerveld, Marianne, Cheng, Caroline, van Woerden, Geeske M., Mozaffari, Melika, Post, Laura, Duckers, Henricus J., Nellist, Mark, Elgersma, Ype

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion by Kool, Martijn J., van de Bree, Jolet E., Bodde, Hanna E., Elgersma, Ype, van Woerden, Geeske M.

“…Genetic approaches using temporal and brain region-specific restricted gene deletions have provided a wealth of insight in the brain regions and temporal…”
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Focused ultrasound neuromodulation on a multiwell MEA by Saccher, Marta, Kawasaki, Shinnosuke, Onori, Martina Proietti, van Woerden, Geeske M, Giagka, Vasiliki, Dekker, Ronald

“…Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation…”
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Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice by Rigter, Pomme M.F., Wallaard, Ilse, Aghadavoud Jolfaei, Mehrnoush, Kingma, Jenina, Post, Laura, Elgersma, Minetta, Elgersma, Ype, van Woerden, Geeske M.

“…With the recent findings that mutations in the gene encoding the α-subunit of calcium/calmodulin-dependent protein kinase II (CAMK2A) causes a…”
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CAMK2-Dependent Signaling in Neurons Is Essential for Survival by Kool, Martijn J., Proietti Onori, Martina, Borgesius, Nils Z., van de Bree, Jolet E., Elgersma-Hooisma, Minetta, Nio, Enzo, Bezstarosti, Karel, Buitendijk, Gabriëlle H.S., Aghadavoud Jolfaei, Mehrnoush, Demmers, Jeroen A.A., Elgersma, Ype, van Woerden, Geeske M.

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