Search Results - "Van Woerden, G. M."

HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1 by Omrani, A, van der Vaart, T, Mientjes, E, van Woerden, G M, Hojjati, M R, Li, K W, Gutmann, D H, Levelt, C N, Smit, A B, Silva, A J, Kushner, S A, Elgersma, Y

“…Cognitive impairments are a major clinical feature of the common neurogenetic disease neurofibromatosis type 1 (NF1). Previous studies have demonstrated that…”
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Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors by Olijslagers, J. E., De Kloet, E. R., Elgersma, Y., Van Woerden, G. M., Joëls, M., Karst, H.

“…Corticosterone (100 nm) rapidly increases the frequency of miniature excitatory postsynaptic currents in mouse CA1 pyramidal neurons via membrane‐located…”
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Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability by Reijnders, M. R. F., Kousi, M., van Woerden, G. M., Klein, M., Bralten, J., Mancini, G. M. S., van Essen, T., Proietti-Onori, M., Smeets, E. E. J., van Gastel, M., Stegmann, A. P. A., Stevens, S. J. C., Lelieveld, S. H., Gilissen, C., Pfundt, R., Tan, P. L., Kleefstra, T., Franke, B., Elgersma, Y., Katsanis, N., Brunner, H. G.

“…De novo mutations in specific mTOR pathway genes cause brain overgrowth in the context of intellectual disability (ID). By analyzing 101 mMTOR-related genes in…”
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Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum by van der Vaart, T., van Woerden, G. M., Elgersma, Y., de Zeeuw, C. I., Schonewille, M.

“…Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited disease, characterized by various neurocutaneous symptoms, cognitive impairments and…”
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Neurofibromin regulates HCN activity in Parvalbumin-positive interneurons by Omrani, A, van Woerden, G M, Elgersma, Y

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Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates by Tonazzini, I., Meucci, S., Van Woerden, G. M., Elgersma, Y., Cecchini, M.

“…Recent discoveries indicate that during neuronal development the signaling processes that regulate extracellular sensing (e.g., adhesion, cytoskeletal…”
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CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting  CaMKII to Synapses by Borgesius, N. Z., van Woerden, G. M., Buitendijk, G. H. S., Keijzer, N., Jaarsma, D., Hoogenraad, C. C., Elgersma, Y.

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Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments by Goorden, Susanna M I, Abs, Elisabeth, Bruinsma, Caroline F, Riemslagh, Fréderike W, van Woerden, Geeske M, Elgersma, Ype

“…Target of rapamycin complex 1 (TORC1) is an important regulator of neuronal function. However, whereas a modest activation of the TORC1 signaling pathway has…”
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Episodic memory in dementia of the Alzheimer type and in normal ageing: similar impairment in automatic processing by Abbenhuis, M A, Raaijmakers, W G, Raaijmakers, J G, van Woerden, G J

“…A perceptual identification task was used to provide an implicit measure for automatic memory processes. The facilitation of word identification on repeated…”
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