Search Results - "Van Weering, T."

Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation by Jorge-Oliva, Marta, van Weering, Jan R T, Scheper, Wiep

“…Tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons…”
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Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes by Meijer, Marieke, Öttl, Miriam, Yang, Jie, Subkhangulova, Aygul, Kumar, Avinash, Feng, Zicheng, van Voorst, Torben W., Groffen, Alexander J., van Weering, Jan R. T., Zhang, Yongli, Verhage, Matthijs

“…Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against…”
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Cold-water coral growth under extreme environmental conditions, the Cape Lookout area, NW Atlantic by Mienis, F, Duineveld, G. C. A, Davies, A. J, Lavaleye, M. M. S, Ross, S. W, Seim, H, Bane, J, van Haren, H, Bergman, M. J. N, de Haas, H, Brooke, S, van Weering, T. C. E

“…The Cape Lookout cold-water coral area off the coast of North Carolina forms the shallowest and northernmost cold-water coral mound area on the Blake Plateau…”
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Hydrodynamic controls on cold-water coral growth and carbonate-mound development at the SW and SE Rockall Trough Margin, NE Atlantic Ocean by Mienis, F., de Stigter, H.C., White, M., Duineveld, G., de Haas, H., van Weering, T.C.E.

“…Long-term (⩽1-year) records obtained by seabed observatories (BOBO) and repeated (24-h) CTD casts show the presence of a highly energetic environment in and…”
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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin by Gowrisankaran, Sindhuja, Houy, Sébastien, del Castillo, Johanna G. Peña, Steubler, Vicky, Gelker, Monika, Kroll, Jana, Pinheiro, Paulo S., Schwitters, Dirk, Halbsgut, Nils, Pechstein, Arndt, van Weering, Jan R. T., Maritzen, Tanja, Haucke, Volker, Raimundo, Nuno, Sørensen, Jakob B., Milosevic, Ira

“…Endophilins-A are conserved endocytic adaptors with membrane curvature-sensing and -inducing properties. We show here that, independently of their role in…”
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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies by Batenburg, Kevin L, Sestito, Claudia, Cornelissen-Steijger, Paulien, van Weering, Jan R T, Price, Leo S, Heine, Vivi M, Scheper, Wiep

“…Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also…”
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The influence of near-bed hydrodynamic conditions on cold-water corals in the Viosca Knoll area, Gulf of Mexico by Mienis, F., Duineveld, G.C.A., Davies, A.J., Ross, S.W., Seim, H., Bane, J., van Weering, T.C.E.

“…Near-bed hydrodynamic conditions were recorded for almost one year in the Viosca Knoll area (lease block 826), one of the most well-developed cold-water coral…”
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Near-bed particle deposition and resuspension in a cold-water coral mound area at the Southwest Rockall Trough margin, NE Atlantic by Mienis, F., de Stigter, H.C., de Haas, H., van Weering, T.C.E.

“…Cold-water coral reefs and mounds are observed mainly on slopes and topographic highs, in areas with high current speeds. Previous investigations of the…”
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Reduced mGluR5 Activity Modulates Mitochondrial Function by Gonzalez-Lozano, Miguel A., Wortel, Joke, van der Loo, Rolinka J., van Weering, Jan R. T., Smit, August B., Li, Ka Wan

“…The metabotropic glutamate receptor 5 (mGluR5) is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is…”
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Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains by Geerts, Cornelia J, Mancini, Roberta, Chen, Ning, Koopmans, Frank T W, Li, Ka Wan, Smit, August B, van Weering, Jan R T, Verhage, Matthijs, Groffen, Alexander J A

“…The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. Tomosyn contributes to synapse function…”
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Carbonate mound development at the SW Rockall Trough margin based on high resolution TOBI and seismic recording by Mienis, F., van Weering, T., de Haas, H., de Stigter, H., Huvenne, V., Wheeler, A.

“…In 2002, high-resolution sidescan sonar images of a mound area at the SW Rockall Trough margin were recorded with the TOBI deep towed sidescan sonar. Processed…”
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A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline by Wenzel, Michaela, Dekker, Marien P., Wang, Biwen, Burggraaf, Maroeska J., Bitter, Wilbert, van Weering, Jan R. T., Hamoen, Leendert W.

“…Transmission electron microscopy of cell sample sections is a popular technique in microbiology. Currently, ultrathin sectioning is done on resin-embedded cell…”
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DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion by Friedrich, Reut, Groffen, Alexander J, Connell, Emma, van Weering, Jan R. T, Gutman, Orit, Henis, Yoav I, Davletov, Bazbek, Ashery, Uri

“…Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small…”
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Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons by Subkhangulova, Aygul, Gonzalez-Lozano, Miguel A, Groffen, Alexander JA, van Weering, Jan RT, Smit, August B, Toonen, Ruud F, Verhage, Matthijs

“…Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the…”
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Cold-water coral habitats of Rockall and Porcupine Bank, NE Atlantic Ocean: Sedimentary facies and benthic foraminiferal assemblages by Smeulders, G.G.B., Koho, K.A., de Stigter, H.C., Mienis, F., de Haas, H., van Weering, T.C.E.

“…The extent of the cold-water coral mounds in the modern ocean basins has been recently revealed by new state-of-the-art equipment. However, not much is known…”
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Cold-water coral mounds on the Pen Duick Escarpment, Gulf of Cadiz: The MiCROSYSTEMS project approach by Van Rooij, D., Blamart, D., De Mol, L., Mienis, F., Pirlet, H., Wehrmann, L.M., Barbieri, R., Maignien, L., Templer, S.P., de Haas, H., Hebbeln, D., Frank, N., Larmagnat, S., Stadnitskaia, A., Stivaletta, N., van Weering, T., Zhang, Y., Hamoumi, N., Cnudde, V., Duyck, P., Henriet, J.-P.

“…Here we present a case study of three cold-water coral mounds in a juvenile growth stage on top of the Pen Duick Escarpment in the Gulf of Cadiz; Alpha, Beta…”
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The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators by Persoon, Claudia M., Hoogstraaten, Rein I., Nassal, Joris P., van Weering, Jan R.T., Kaeser, Pascal S., Toonen, Ruud F., Verhage, Matthijs

“…Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain…”
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Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology by Wiersma, Vera I., van Ziel, Anna Maria, Vazquez-Sanchez, Sonia, Nölle, Anna, Berenjeno-Correa, Ernesto, Bonaterra-Pastra, Anna, Clavaguera, Florence, Tolnay, Markus, Musters, René J. P., van Weering, Jan R. T., Verhage, Matthijs, Hoozemans, Jeroen J. M., Scheper, Wiep

“…Granulovacuolar degeneration bodies (GVBs) are membrane-bound vacuolar structures harboring a dense core that accumulate in the brains of patients with…”
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Pool size estimations for dense‐core vesicles in mammalian CNS neurons by Persoon, Claudia M, Moro, Alessandro, Nassal, Joris P, Farina, Margherita, Broeke, Jurjen H, Arora, Swati, Dominguez, Natalia, van Weering, Jan RT, Toonen, Ruud F, Verhage, Matthijs

“…Neuropeptides are essential signaling molecules transported and secreted by dense‐core vesicles (DCVs), but the number of DCVs available for secretion, their…”
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Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules by van Weering, Jan R T, Sessions, Richard B, Traer, Colin J, Kloer, Daniel P, Bhatia, Vikram K, Stamou, Dimitrios, Carlsson, Sven R, Hurley, James H, Cullen, Peter J

“…Sorting nexins (SNXs) are regulators of endosomal sorting. For the SNX‐BAR subgroup, a Bin/Amphiphysin/Rvs (BAR) domain is vital for formation/stabilization of…”
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