Search Results - "Van Weeghel, M"

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin by Ramirez-Moral, I., Yu, X., Butler, J. M., van Weeghel, M., Otto, N. A., Ferreira, B. Lima, Maele, L. Van, Sirard, J. C., de Vos, A. F., de Jong, M. D., Houtkooper, R. H., van der Poll, T.

“…Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective…”
Get full text

Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib by Krishnamurthy, K A, Rutten, M G S, Hoogerland, J A, van Dijk, T H, Bos, T, Koehorst, M, de Vries, M P, Kloosterhuis, N J, Havinga, H, Schomakers, B V, van Weeghel, M, Wolters, J C, Bakker, B M, Oosterveer, M H

“…Carbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription factor that acts as a metabolic switch to…”
Get full text

Insulin and glycolysis dependency of cardioprotection by nicotinamide riboside by Xiao, Y., Wang, Q., Zhang, H., Nederlof, R., Bakker, D., Siadari, B. A., Wesselink, M. W., Preckel, B., Weber, N. C., Hollmann, M. W., Schomakers, B. V., van Weeghel, M., Zuurbier, C. J.

“…Decreased nicotinamide adenine dinucleotide (NAD + ) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia–reperfusion…”
Get full text

Right ventricular pressure overload alters cardiac lipid composition by Koop, A.M.C., Hagdorn, Q.A.J., Bossers, G.P.L., van Leusden, T., Gerding, A., van Weeghel, M., Vaz, F.M., Koonen, D.P.Y., Silljé, H.H.W., Berger, R.M.F., Bartelds, B.

“…Right ventricular (RV) failure due to pressure load is an important determinant of clinical outcome in pulmonary hypertension, congenital heart disease and…”
Get full text

Nicotinamide riboside cardioprotection is mediated through glycolysis activation by Xiao, Y, Wang, Q, Preckel, B, Hollmann, M W, Weber, N C, Schomakers, B V, Van Weeghel, M, Zuurbier, C

“…Abstract Purpose Low NAD+ levels are observed in pathologies such as ageing, diabetes, heart failure and ischemia-reperfusion (IR) injury. Nicotinamide…”
Get full text

Metabolomics to characterise adaptations in cellular metabolism for the stages of atrial fibrillation by Wijdeveld, L F J M, Pool, L, Van Weeghel, M, Schomakers, B V, De Groot, N M S, Houtkooper, R H, Brundel, B J J M

“…Abstract Background Atrial fibrillation (AF) is a highly prevalent, progressive cardiac arrhythmia associated with high cardiovascular comorbidity. Current…”
Get full text

The Effect Of Mirabegron On Energy Expenditure, Brown Adipose Tissue And The Lipidomic Profile In Healthy Lean South Asian And White Caucasian Men by Martinez-Tellez, B., Nahon, K.J., Janssen, L.G.M., Sardjoe-Mishre, A.S., van Weeghel, M., Vaz, F.M., Houtkooper, R., Burakiewicz, J., Dzyubachyk, O., Kooijman, S., Webb, A.G., Kan, H.E., Berbée, J.F.P., Jazet, I.M., Boon, M., Rensen, P.C.N.

Get full text

Targeting Lipoprotein(A)-Induced Endothelial Cell Metabolic Reprogramming Reverses Inflammation And Leukocyte Migration by Schnitzler, J., Hoogeveen, R., Ali, L., Prange, K., Van Weeghel, M., Bachmann, J., Versloot, M., Houtkooper, R., Tsimikas, S., Koschinksky, M., De Winther, M., Groen, A., Stroes, E., Kroon, J.

Get full text