Search Results - "Van Veelen, Peter"

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport by Jongsma, Marlieke L.M., Berlin, Ilana, Wijdeven, Ruud H.M., Janssen, Lennert, Janssen, George M.C., Garstka, Malgorzata A., Janssen, Hans, Mensink, Mark, van Veelen, Peter A., Spaapen, Robbert M., Neefjes, Jacques

“…Through a network of progressively maturing vesicles, the endosomal system connects the cell’s interior with extracellular space. Intriguingly, this network…”
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Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses by Lehmann, Kathleen C, Gulyaeva, Anastasia, Zevenhoven-Dobbe, Jessika C, Janssen, George M C, Ruben, Mark, Overkleeft, Hermen S, van Veelen, Peter A, Samborskiy, Dmitry V, Kravchenko, Alexander A, Leontovich, Andrey M, Sidorov, Igor A, Snijder, Eric J, Posthuma, Clara C, Gorbalenya, Alexander E

“…RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging…”
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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2 by Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, Wiertz, Emmanuel J H J

“…Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these…”
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ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab by Duarte, Henrique O., Rodrigues, Joana G., Gomes, Catarina, Hensbergen, Paul J., Ederveen, Agnes L. Hipgrave, de Ru, Arnoud H., Mereiter, Stefan, Polónia, António, Fernandes, Elisabete, Ferreira, José A., van Veelen, Peter A., Santos, Lúcio L., Wuhrer, Manfred, Gomes, Joana, Reis, Celso A.

“…The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely…”
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The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling by Treffers, Emmely E, Tas, Ali, Scholte, Florine E M, de Ru, Arnoud H, Snijder, Eric J, van Veelen, Peter A, van Hemert, Martijn J

“…Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central…”
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Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines by Pirro, Martina, Rombouts, Yoann, Stella, Alexandre, Neyrolles, Olivier, Burlet-Schiltz, Odile, van Vliet, Sandra J., de Ru, Arnoud H., Mohammed, Yassene, Wuhrer, Manfred, van Veelen, Peter A., Hensbergen, Paul J.

“…The Ca2+-dependent C-type lectin receptor Macrophage Galactose-type Lectin (MGL) is highly expressed by tolerogenic dendritic cells (DC) and macrophages. MGL…”
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Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes by Kracht, Maria J L, van Lummel, Menno, Nikolic, Tatjana, Joosten, Antoinette M, Laban, Sandra, van der Slik, Arno R, van Veelen, Peter A, Carlotti, Françoise, de Koning, Eelco J P, Hoeben, Rob C, Zaldumbide, Arnaud, Roep, Bart O

“…Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized…”
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A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells by Luimstra, Jolien J, Garstka, Malgorzata A, Roex, Marthe C J, Redeker, Anke, Janssen, George M C, van Veelen, Peter A, Arens, Ramon, Falkenburg, J H Frederik, Neefjes, Jacques, Ovaa, Huib

“…Adaptive immunity is initiated by T cell recognition of specific antigens presented by major histocompatibility complexes (MHCs). MHC multimer technology has…”
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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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Glycoproteomic Analysis of MGL-Binding Proteins on Acute T‑Cell Leukemia Cells by Pirro, Martina, Schoof, Esmee, van Vliet, Sandra J, Rombouts, Yoann, Stella, Alexandre, de Ru, Arnoud, Mohammed, Yassene, Wuhrer, Manfred, van Veelen, Peter A, Hensbergen, Paul J

“…C-type lectins are a diverse group of proteins involved in many human physiological and pathological processes. Most C-type lectins are glycan-binding…”
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Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein by Fang, Ying, Treffers, Emmely E, Li, Yanhua, Tas, Ali, Sun, Zhi, van der Meer, Yvonne, de Ru, Arnoud H, van Veelen, Peter A, Atkins, John F, Snijder, Eric J, Firth, Andrew E

“…Programmed −1 ribosomal frameshifting (−1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient…”
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes by Ali, Muhammad, Giannakopoulou, Eirini, Li, Yingqian, Lehander, Madeleine, Virding Culleton, Stina, Yang, Weiwen, Knetter, Cathrine, Odabasi, Mete Can, Bollineni, Ravi Chand, Yang, Xinbo, Foldvari, Zsofia, Böschen, Maxi-Lu, Taraldsrud, Eli, Strønen, Erlend, Toebes, Mireille, Hillen, Amy, Mazzi, Stefania, de Ru, Arnoud H., Janssen, George M. C., Kolstad, Arne, Tjønnfjord, Geir Erland, Lie, Benedicte A., Griffioen, Marieke, Lehmann, Sören, Osnes, Liv Toril, Buechner, Jochen, Garcia, K. Christopher, Schumacher, Ton N., van Veelen, Peter A., Leisegang, Matthias, Jacobsen, Sten Eirik W., Woll, Petter, Olweus, Johanna

“…Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we…”
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Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes by van Lummel, Menno, Duinkerken, Gaby, van Veelen, Peter A, de Ru, Arnoud, Cordfunke, Robert, Zaldumbide, Arnaud, Gomez-Touriño, Iria, Arif, Sefina, Peakman, Mark, Drijfhout, Jan W, Roep, Bart O

“…Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG),…”
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The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis by Stavast, Christiaan J., van Zuijen, Iris, Karkoulia, Elena, Özçelik, Arman, van Hoven-Beijen, Antoinette, Leon, Leticia G., Voerman, Jane S. A., Janssen, George M. C., van Veelen, Peter A., Burocziova, Monika, Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Maas, Alex, Bindels, Eric M., van der Velden, Vincent H. J., Schliehe, Christopher, Katsikis, Peter D., Alberich-Jorda, Meritxell, Erkeland, Stefan J.

“…MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular…”
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Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis by Rombouts, Yoann, Willemze, Annemiek, van Beers, Joyce J B C, Shi, Jing, Kerkman, Priscilla F, van Toorn, Linda, Janssen, George M C, Zaldumbide, Arnaud, Hoeben, Rob C, Pruijn, Ger J M, Deelder, André M, Wolbink, Gertjan, Rispens, Theo, van Veelen, Peter A, Huizinga, Tom W J, Wuhrer, Manfred, Trouw, Leendert A, Scherer, Hans U, Toes, René E M

“…To understand the molecular features distinguishing anti-citrullinated protein antibodies (ACPA) from 'conventional' antibodies in rheumatoid arthritis (RA)…”
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Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains by Abendstein, Leoni, Dijkstra, Douwe J., Tjokrodirijo, Rayman T. N., van Veelen, Peter A., Trouw, Leendert A., Hensbergen, Paul J., Sharp, Thomas H.

“…IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies by Kollenstart, Leonie, van der Horst, Sophie C., Vreeken, Kees, Janssen, George M. C., Martino, Fabrizio, Vlaming, Hanneke, van Veelen, Peter A., van Leeuwen, Fred, van Attikum, Haico

“…The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations,…”
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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage by Shi, Jing, Knevel, Rachel, Suwannalai, Parawee, van der Linden, Michael P, Janssen, George M. C, van Veelen, Peter A, Levarht, Nivine E. W, van der Helm-van Mil, Annette H. M, Cerami, Anthony, Huizinga, Tom W. J, Toes, Rene E. M, Trouw, Leendert A

“…Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated…”
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Detecting Proteomic Indicators to Distinguish Diabetic Nephropathy from Hypertensive Nephrosclerosis by Integrating Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging with High-Mass Accuracy Mass Spectrometry by Smith, Andrew, Iablokov, Vadim, Mazza, Mariafrancesca, Guarnerio, Sonia, Denti, Vanna, Ivanova, Mariia, Stella, Martina, Piga, Isabella, Chinello, Clizia, Heijs, Bram, van Veelen, Peter A., Benediktsson, Hallgrimur, Muruve, Daniel A., Magni, Fulvio

“…Introduction: Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many…”
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