Search Results - "Van Valkenburgh, Juno"

Development of a novel radiofluorinated riboflavin probe for riboflavin receptor-targeting PET imaging by Li, Jindian, Valkenburgh, Juno Van, Fang, Jianyang, Zhang, Deliang, Chen, Yingxi, Chen, Quan, Jia, Guorong, Chen, Austin Z., Zhang, Xianzhong, Chen, Kai

“…Riboflavin receptor 3 (RFVT3) is a key protein in energetic metabolism reprogramming and is overexpressed in multiple cancers involved in malignant…”
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Small molecules as theranostic agents in cancer immunology by Li, Jindian, Van Valkenburgh, Juno, Hong, Xingfang, Conti, Peter S, Zhang, Xianzhong, Chen, Kai

“…With further research into the molecular mechanisms and roles linking immune suppression and restraint of (pre)malignancies, immunotherapies have…”
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Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma by Jia, Guorong, Van Valkenburgh, Juno, Chen, Austin Z., Chen, Quan, Li, Jindian, Zuo, Changjing, Chen, Kai

“…Transarterial chemoembolization (TACE) is a recommended treatment for patients suffering from intermediate and advanced hepatocellular carcinoma (HCC). As…”
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Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases by Van Valkenburgh, Juno, Meuret, Cristiana, Martinez, Ashley E., Kodancha, Vibha, Solomon, Victoria, Chen, Kai, Yassine, Hussein N.

“…High-density lipoproteins (HDLs) are complex, heterogenous lipoprotein particles, consisting of a large family of apolipoproteins, formed in subspecies of…”
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Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs by Plamthottam, Sheba, Sun, Daniel, Van Valkenburgh, Juno, Valenzuela, Jeffrey, Ruehle, Bastian, Steele, Dalton, Poddar, Soumya, Marshalik, Maxim, Hernandez, Selena, Radu, Caius Gabriel, Zink, Jeffrey I.

“…Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results…”
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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity by Kim, Woosuk, Le, Thuc M., Wei, Liu, Poddar, Soumya, Bazzy, Jimmy, Wang, Xuemeng, Uong, Nhu T., Abt, Evan R., Capri, Joseph R., Austin, Wayne R., Van Valkenburgh, Juno S., Steele, Dalton, Gipson, Raymond M., Slavik, Roger, Cabebe, Anthony E., Taechariyakul, Thotsophon, Yaghoubi, Shahriar S., Lee, Jason T., Sadeghi, Saman, Lavie, Arnon, Faull, Kym F., Witte, Owen N., Donahue, Timothy R., Phelps, Michael E., Herschman, Harvey R., Herrmann, Ken, Czernin, Johannes, Radu, Caius G.

“…Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission…”
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Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge by Wang, Siwen, Li, Zhonghan, Aispuro, Desiree, Guevara, Nathan, Van Valkenburgh, Juno, Chen, Boxi, Zhou, Xiaoyun, McCarroll, Matthew N., Ji, Fei, Cong, Xu, Sarkar, Priyanka, Chaudhuri, Rohit, Guo, Zhili, Perkins, Nicole P., Shao, Shiqun, Sello, Jason K., Chen, Kai, Xue, Min

“…Delivering cargo molecules across the plasma membrane is critical for biomedical research, and the need to develop molecularly well-defined tags that enable…”
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Monitoring DHA and AA Brain Uptake in ApoE4 Mice with 18 F‐Fluorinated PET Tracers by Duro, Marlon Vincent V., Van Valkenburgh, Juno S., Kerman, Bilal E., Wang, Shaowei, Liu, Xiaodan, Sta, Naomi, Zanderigo, Francesca, Jacobs, Russell E., Chen, Kai, Yassine, Hussein N.

“…Abstract Background Polyunsaturated fatty acids (PUFAs) are the precursors of various lipid mediators of inflammation. Brain imaging techniques for monitoring…”
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Monitoring DHA and AA Brain Uptake in ApoE4 Mice with 18F‐Fluorinated PET Tracers by Duro, Marlon Vincent V., Van Valkenburgh, Juno S., Kerman, Bilal E., Wang, Shaowei, Liu, Xiaodan, Sta, Naomi, Zanderigo, Francesca, Jacobs, Russell E., Chen, Kai, Yassine, Hussein N.

“…Background Polyunsaturated fatty acids (PUFAs) are the precursors of various lipid mediators of inflammation. Brain imaging techniques for monitoring the…”
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Inhibition of calcium‐dependent phospholipase A2 improves blood‐brain barrier integrity in ApoE4 carrying mice by Kerman, Bilal E., Duro, Marlon Vincent V., Maria, Naomi Sta, Liu, Xiaodan, Wang, Shaowei, Van Valkenburgh, Juno S., Chen, Kai, Jacobs, Russell E., Yassine, Hussein N.

“…Background Blood‐brain barrier (BBB) is essential for neural health and function. Degradation of BBB is observed in Alzheimer’s disease (AD) and is more…”
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Manipulation of Dietary DHA does not Alter DHA Brain Uptake Kinetics in Mice Despite Changing Brain and Plasma DHA Levelsvs by Duro, Marlon Vincent V., Van Valkenburgh, Juno S., Abdullah, Laila, Ingles, Diana E., Cai, Zhiheng, Kerman, Bilal Ersen, Wang, Shaowei, Jacobs, Russell E., Sta. Maria, Naomi, Zanderigo, Francesca, Croteau, Etienne, Cunnane, Stephen, Rapoport, Stanley I., Chen, Kai, Yassine, Hussein N.

“…Background Increased brain docosahexaenoic acid (DHA) uptake reflects a compensatory mechanism for maintaining brain DHA homeostasis and can be captured…”
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EGFR Mutation Status and Subtypes Predicted by CT-Based 3D Radiomic Features in Lung Adenocarcinoma by Chen, Quan, Li, Yan, Cheng, Qiguang, Van Valkenburgh, Juno, Sun, Xiaotian, Zheng, Chuansheng, Zhang, Ruiguang, Yuan, Rong

“…In this study, we aim to establish a non-invasive tool to predict epidermal growth factor receptor (EGFR) mutation status and subtypes based on radiomic…”
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Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice by Van Valkenburgh, Juno, Duro, Marlon Vincent V., Burnham, Erica, Chen, Quan, Wang, Shaowei, Tran, Jenny, Kerman, Bilal E., Hwang, Sung Hee, Liu, Xiaodan, Sta. Maria, Naomi S., Zanderigo, Francesca, Croteau, Etienne, Rapoport, Stanley I., Cunnane, Stephen C., Jacobs, Russell E., Yassine, Hussein N., Chen, Kai

“…•An increase in brain arachidonic acid (AA) uptake is a marker of calcium-dependent phospholipase A2 activation and neuroinflammation.•A novel translational…”
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Exploring Solvent Effects in the Radiosynthesis of 18 F-Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging by Li, Jindian, Van Valkenburgh, Juno, Conti, Peter S, Chen, Kai

“…Thymidine analogues, 5-substituted 2'-deoxy-2'-[ F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being…”
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Exploring Solvent Effects in the Radiosynthesis of 18F‑Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging by Li, Jindian, Van Valkenburgh, Juno, Conti, Peter S, Chen, Kai

“…Thymidine analogues, 5-substituted 2′-deoxy-2′-[18F]­fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being…”
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Synthesis and Preclinical Evaluation of 22‑[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics by Duro, Marlon Vincent V., Van Valkenburgh, Juno, Ingles, Diana E., Tran, Jenny, Cai, Zhiheng, Ebright, Brandon, Wang, Shaowei, Kerman, Bilal E., Galvan, Jasmin, Hwang, Sung Hee, Sta Maria, Naomi S., Zanderigo, Francesca, Croteau, Etienne, Cunnane, Stephen C., Rapoport, Stanley I., Louie, Stan G., Jacobs, Russell E., Yassine, Hussein N., Chen, Kai

“…Docosahexaenoic acid [22:6­(n-3), DHA], a polyunsaturated fatty acid, has an important role in regulating neuronal functions and in normal brain development…”
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Development of Small-Molecule Modulators of Nucleotide Metabolism Enzymes by Van Valkenburgh, Juno Simone

“…In chapter 1, strategies toward the asymmetric synthesis of a deoxycytidine kinase (dCK) inhibitor are presented. Small molecule dCK inhibitors are potential…”
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Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias by Sun, Daniel L, Poddar, Soumya, Pan, Roy D, Rosser, Ethan W, Abt, Evan R, Van Valkenburgh, Juno, Le, Thuc M, Lok, Vincent, Hernandez, Selena P, Song, Janet, Li, Joanna, Turlik, Aneta, Chen, Xiaohong, Cheng, Chi-An, Chen, Wei, Mona, Christine E, Stuparu, Andreea D, Vergnes, Laurent, Reue, Karen, Damoiseaux, Robert, Zink, Jeffrey I, Czernin, Johannes, Donahue, Timothy R, Houk, Kendall N, Jung, Michael E, Radu, Caius G

“…A potent class of isoquinoline-based α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) compounds has been rediscovered; based upon this scaffold, three…”
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Isoquinoline thiosemicarbazone displays potent anticancer activity with efficacy against aggressive leukemias by Sun, Daniel L, Poddar, Soumya, Pan, Roy D, Rosser, Ethan W, Abt, Evan R, Van Valkenburgh, Juno, Le, Thuc M, Lok, Vincent, Hernandez, Selena P, Song, Janet, Li, Joanna, Turlik, Aneta, Chen, Xiaohong, Cheng, Chi-An, Chen, Wei, Mona, Christine E, Stuparu, Andreea D, Vergnes, Laurent, Reue, Karen, Damoiseaux, Robert, Zink, Jeffrey I, Czernin, Johannes, Donahue, Timothy R, Houk, Kendall N, Jung, Michael E, Radu, Caius G

“…A potent class of isoquinoline-based α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) compounds has been rediscovered; based upon this scaffold, three…”
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Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias† †The authors declare the following competing financial interest(s): C. G. R., J. C., and M. E. J. are co-founders of Trethera Corporation. They and the University of California hold equity in Trethera Corporation. The University of California has patented additional intellectual property for thiosemicarbazone-based antiproliferative compounds. ‡ ‡Electronic supplementary informa by Sun, Daniel L., Poddar, Soumya, Pan, Roy D., Rosser, Ethan W., Abt, Evan R., Van Valkenburgh, Juno, Le, Thuc M., Lok, Vincent, Hernandez, Selena P., Song, Janet, Li, Joanna, Turlik, Aneta, Chen, Xiaohong, Cheng, Chi-An, Chen, Wei, Mona, Christine E., Stuparu, Andreea D., Vergnes, Laurent, Reue, Karen, Damoiseaux, Robert, Zink, Jeffrey I., Czernin, Johannes, Donahue, Timothy R., Houk, Kendall N., Jung, Michael E., Radu, Caius G.

“…Potent α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) antiproliferatives were synthesized through iterative rounds of methylation and fluorination…”
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