Search Results - "Van Swearingen, Amanda E D"

Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice by Biskup, Caroline Sarah, Sánchez, Cristina L, Arrant, Andrew, Van Swearingen, Amanda E D, Kuhn, Cynthia, Zepf, Florian Daniel

“…Acute tryptophan depletion (ATD) is a method of lowering brain serotonin (5-HT). Administration of large neutral amino acids (LNAA) limits the transport of…”
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Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes by Leslie, Patrick L., Chao, Yvonne L., Tsai, Yi-Hsuan, Ghosh, Subrata K., Porrello, Alessandro, Van Swearingen, Amanda E. D., Harrison, Emily B., Cooley, Brian C., Parker, Joel S., Carey, Lisa A., Pecot, Chad V.

“…Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial…”
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HER2‐positive breast cancer brain metastasis: A new and exciting landscape by Zimmer, Alexandra S., Van Swearingen, Amanda E. D., Anders, Carey K.

“…Background Brain metastases (BrM) incidence is 25% to 50% in women with advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer…”
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LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases by Van Swearingen, Amanda E. D., Siegel, Marni B., Deal, Allison M., Sambade, Maria J., Hoyle, Alan, Hayes, D. Neil, Jo, Heejoon, Little, Paul, Dees, Elizabeth Claire, Muss, Hyman, Jolly, Trevor, Zagar, Timothy M., Patel, Nirali, Miller, C. Ryan, Parker, Joel S., Smith, J. Keith, Fisher, Julie, Shah, Nikita, Nabell, Lisle, Nanda, Rita, Dillon, Patrick, Abramson, Vandana, Carey, Lisa A., Anders, Carey K.

“…Purpose HER2 + breast cancer (BC) is an aggressive subtype with high rates of brain metastases (BCBM). Two-thirds of HER2 + BCBM demonstrate activation of the…”
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Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan by Alder, Laura, Trapani, Dario, Bradbury, Claire, Van Swearingen, Amanda E. D., Tolaney, Sara M., Khasraw, Mustafa, Anders, Carey K., Lascola, Christopher D., Hsu, Liangge, Lin, Nancy U., Sammons, Sarah

“…Leptomeningeal metastases (LM) are a devastating complication of HER2 + metastatic breast cancer (MBC), with no effective treatments. In a case series of 8…”
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Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice by Van Swearingen, Amanda E. D., Walker, Q. David, Kuhn, Cynthia M.

“…Rationale Women are more sensitive than men to psychostimulants and progress from initial use to drug addiction more quickly. The mouse has been an…”
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Brain metastasis as the first and only metastatic relapse site portends worse survival in patients with advanced HER2 + breast cancer by Noteware, Laura, Broadwater, Gloria, Dalal, Nicole, Alder, Laura, Herndon II, James E., Floyd, Scott, Giles, William, Van Swearingen, Amanda E. D., Anders, Carey K., Sammons, Sarah

“…Purpose Current systemic therapy guidelines for patients with HER2 + breast cancer brain metastases (BCBrM) diverge based on the status of extracranial disease…”
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Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases by Dhakal, Ajay, Van Swearingen, Amanda E. D., O’Regan, Ruth, Anders, Carey K.

“…Opinion statement Brain metastasis arising from breast cancer is associated with a poor prognosis. Various systemic chemotherapy and targeted therapies which…”
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Simplified dietary acute tryptophan depletion: effects of a novel amino acid mixture on the neurochemistry of C57BL/6J mice by Sánchez, Cristina L., Van Swearingen, Amanda E. D., Arrant, Andrew E., Biskup, Caroline S., Kuhn, Cynthia M., Zepf, Florian D.

“…Diet and nutrition can impact on the biological processes underpinning neuropsychiatric disorders. Amino acid (AA) mixtures lacking a specific neurotransmitter…”
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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis by Nelson, Kimberly J, Perkins, Arden, Van Swearingen, Amanda E D, Hartman, Steven, Brereton, Andrew E, Parsonage, Derek, Salsbury, Jr, Freddie R, Karplus, P Andrew, Poole, Leslie B

“…Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of…”
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Systemic Therapy Type and Timing Effects on Radiation Necrosis Risk in HER2+ Breast Cancer Brain Metastases Patients Treated With Stereotactic Radiosurgery by Park, Christine, Buckley, Evan D, Van Swearingen, Amanda E D, Giles, Will, Herndon, James E, Kirkpatrick, John P, Anders, Carey K, Floyd, Scott R

“…There is a concern that HER2-directed systemic therapies, when administered concurrently with stereotactic radiosurgery (SRS), may increase the risk of…”
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Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419 by Routh, Eric D., Van Swearingen, Amanda E. D., Sambade, Maria J., Vensko, Steven, McClure, Marni B., Woodcock, Mark G., Chai, Shengjie, Cuaboy, Luz A., Wheless, Amy, Garrett, Amy, Carey, Lisa A., Hoyle, Alan P., Parker, Joel S., Vincent, Benjamin G., Anders, Carey K.

“…Background Triple negative breast cancer (TNBC) is an aggressive variant of breast cancer that lacks the expression of estrogen and progesterone receptors (ER…”
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A Need for More Molecular Profiling in Brain Metastases by Shen, Erica, Van Swearingen, Amanda E D, Price, Meghan J, Bulsara, Ketan, Verhaak, Roeland G W, Baëta, César, Painter, Brice D, Reitman, Zachary J, Salama, April K S, Clarke, Jeffrey M, Anders, Carey K, Fecci, Peter E, Goodwin, C Rory, Walsh, Kyle M

“…As local disease control improves, the public health impact of brain metastases (BrM) continues to grow. Molecular features are frequently different between…”
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Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA by Papke, Bjoern, Azam, Salma H, Feng, Anne Y, Gutierrez-Ford, Christina, Huggins, Hayden, Pallan, Pradeep S, Van Swearingen, Amanda E. D, Egli, Martin, Cox, Adrienne D, Der, Channing J, Pecot, Chad V

“…Oncogenic mutations in the KRAS gene are well-established drivers of cancer. While the recently developed KRASG12C inhibitors offer a targeted KRAS therapy and…”
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Evaluating the efficacy of a priming dose of cyclophosphamide prior to pembrolizumab to treat metastatic triple negative breast cancer by Anders, Carey K, Woodcock, Mark G, Van Swearingen, Amanda E D, Moore, Dominic T, Sambade, Maria J, Laurie, Sonia, Robeson, Alexander, Kolupaev, Oleg, Cuaboy, Luz A, Garrett, Amy L, McKinnon, Karen, Cowens, Kristen, Bortone, Dante, Calhoun, Benjamin C, Wilkinson, Alec D, Carey, Lisa, Jolly, Trevor, Muss, Hyman, Reeder-Hayes, Katherine, Kaltman, Rebecca, Jankowitz, Rachel, Gudena, Vinay, Olajide, Oludamilola, Perou, Charles, Dees, E Claire, Vincent, Benjamin G, Serody, Jonathan S

“…PurposeTriple negative breast cancer (TNBC) is characterized by the presence of immune cells in the tumor microenvironment, however, the response to…”
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Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures by Sánchez, Cristina L., Van Swearingen, Amanda E. D., Arrant, Andrew E., Kuhn, Cynthia M., Zepf, Florian D.

“…Amino acid (AA) depletion techniques have been used to decrease serotonin (5-HT) and/or dopamine (DA) synthesis after administration of a tryptophan (acute…”
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Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy by Walker, Q. David, Johnson, Misha L., Van Swearingen, Amanda E.D., Arrant, Andrew E., Caster, Joseph M., Kuhn, Cynthia M.

“…Ovarian hormones modulate the pharmacological effects of psychostimulants and may enhance vulnerability to drug addiction. Female rats have more midbrain…”
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Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases by Kabraji, Sheheryar, Ni, Jing, Sammons, Sarah, Li, Tianyu, Van Swearingen, Amanda E D, Wang, Yanzhi, Pereslete, Alyssa, Hsu, Liangge, DiPiro, Pamela J, Lascola, Chris, Moore, Heather, Hughes, Melissa, Raghavendra, Akshara S, Gule-Monroe, Maria, Murthy, Rashmi K, Winer, Eric P, Anders, Carey K, Zhao, Jean J, Lin, Nancy U

“…Brain metastases can occur in up to 50% of patients with metastatic HER2-positive breast cancer. Because patients with active brain metastases were excluded…”
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Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer by Siegel, Marni B, He, Xiaping, Hoadley, Katherine A, Hoyle, Alan, Pearce, Julia B, Garrett, Amy L, Kumar, Sunil, Moylan, Vincent J, Brady, Claudia M, Van Swearingen, Amanda Ed, Marron, David, Gupta, Gaorav P, Thorne, Leigh B, Kieran, Niamh, Livasy, Chad, Mardis, Elaine R, Parker, Joel S, Chen, Mengjie, Anders, Carey K, Carey, Lisa A, Perou, Charles M

“…Breast cancer metastasis remains a clinical challenge, even within a single patient across multiple sites of the disease. Genome-wide comparisons of both the…”
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Triple Negative Breast Cancer and Brain Metastases by Bansal, Rani, Van Swearingen, Amanda E D, Anders, Carey K

“…The treatment of metastatic breast cancer (MBC) has improved over the past decade, however prognosis continues to be mitigated by the fact that about 1 in 5…”
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