Search Results - "Van Summeren, Anke"

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro by Van den Hof, Wim F.P.M., Ruiz-Aracama, Ainhoa, Van Summeren, Anke, Jennen, Danyel G.J., Gaj, Stan, Coonen, Maarten L.J., Brauers, Karen, Wodzig, Will K.W.H., van Delft, Joost H.M., Kleinjans, Jos C.S.

“…•Integrated analyses of transcriptome and metabonome results in relevant pathways.•We could unravel mechanisms underlying Cyclosporin A-induced…”
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Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells by Van Summeren, Anke, Renes, Johan, Bouwman, Freek G, Noben, Jean-Paul, van Delft, Joost H M, Kleinjans, Jos C S, Mariman, Edwin C M

“…Unexpected hepatotoxicity is one of the major reasons of drugs failing in clinical trials. This emphasizes the need for new screening methods that address…”
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Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity by Van Summeren, Anke, Renes, Johan, van Delft, Joost H.M., Kleinjans, Jos C.S., Mariman, Edwin C.M.

“…The safety assessment for pharmaceuticals includes in vivo repeated dose toxicity tests in laboratory animals. These in vivo studies often generate false…”
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Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity by Van den Hof, Wim F.P.M, Van Summeren, Anke, Lommen, Arjen, Coonen, Maarten L.J, Brauers, Karen, van Herwijnen, Marcel, Wodzig, Will K.W.H, Kleinjans, Jos C.S

“…Abstract The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better…”
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Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain by Jiang, Jian, Briedé, Jacob J., Jennen, Danyel G.J., Van Summeren, Anke, Saritas-Brauers, Karen, Schaart, Gert, Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…•Toxic doses of acetaminophen (APAP) boost the formation of mitochondrial reactive oxygen species (ROS).•Toxic doses of APAP disrupt the expression of many…”
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Response to Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells by Van Summeren, Anke, Renes, Johan, Mariman, Edwin C. M., Kleinjans, Jos C. S., van Delft, Joost H. M.

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Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach by Van Summeren, Anke, Renes, Johan, Lizarraga, Daneida, Bouwman, Freek G, Noben, Jean-Paul, van Delft, Joost H M, Kleinjans, Jos C S, Mariman, Edwin C M

“…Drug-induced hepatotoxicity is a leading cause of attrition for candidate pharmaceuticals in development. New preclinical screening methods are crucial to…”
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