Acute generalized exanthematous pustulosis induced by paracetamol. A case with severe hemodynamic disturbances

We report on a 28-year-old Bangladesh man with acute generalized exanthematous pustulosis, induced by paracetamol. The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. After intravenous administration of propacetamol hydrochloride (...

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Bibliographic Details
Published in:	Dermatology (Basel) Vol. 193; no. 4; p. 338
Main Authors:	De Coninck, A L, Van Strubarq, A S, Pipeleers-Marichal, M A, Huyghens, L P, Suys, E T, Roseeuw, D I
Format:	Journal Article
Language:	English
Published:	Switzerland 1996
Subjects:	Acetaminophen - adverse effects Acetaminophen - therapeutic use Acute Disease Adult Analgesics, Non-Narcotic - adverse effects Analgesics, Non-Narcotic - therapeutic use Diagnosis, Differential Drug Eruptions - etiology Drug Eruptions - physiopathology Humans Male Patch Tests Skin Diseases, Papulosquamous - chemically induced
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Summary:	We report on a 28-year-old Bangladesh man with acute generalized exanthematous pustulosis, induced by paracetamol. The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. After intravenous administration of propacetamol hydrochloride (which is a prodrug of paracetamol), the rash became worse, showing a toxic epidermal necrolysis-like appearance and the patient suffered from severe hemodynamic disturbances. After discontinuation of propacetamol hydrochloride, the eruption cleared within 2 days. Prick testing performed in the patient revealed a positive reaction for propacetamol hydrochloride.
ISSN:	1018-8665
DOI:	10.1159/000246286