Search Results - "Van Speybroeck, Michel"

Haematology Outcomes Network in Europe (HONEUR)—A collaborative, interdisciplinary platform to harness the potential of real‐world data in hematology by Bardenheuer, Kristina, Van Speybroeck, Michel, Hague, Clare, Nikai, Enkeleida, Price, Martin

“…Introduction There remains a need to optimize treatments and improve outcomes among patients with hematologic malignancies. The timely synthesis and analysis…”
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Increase transparency and reproducibility of real‐world evidence in rare diseases through disease‐specific Federated Data Networks by Baalen, Valerie, Didden, Eva‐Maria, Rosenberg, Daniel, Bardenheuer, Kristina, Speybroeck, Michel, Brand, Monika

“…Purpose In rare diseases, real‐world evidence (RWE) generation is often restricted due to small patient numbers and global geographic distribution. A federated…”
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611 Advancing data harmonization in a federated model/network for assessing patient characteristics in systemic lupus erythematosus by Speybroeck, Michel van, Simon, Teresa A, Lewi, Martine, Sonmez, Reyhan, Nikai, Enkeleida, Carter, Chureen, Sbarigia, Urbano, Zazzetti, Federico, Lavie, Frederic, Karyekar, Chetan S

“…Background/PurposeSystemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations across patient populations. Although real-word…”
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Identification of PsA phenotypes with machine learning analytics using data from two phase III clinical trials of guselkumab in a bio-naïve population of patients with PsA by Richette, Pascal, Vis, Marijn, Ohrndorf, Sarah, Tillett, William, Ramírez, Julio, Neuhold, Marlies, van Speybroeck, Michel, Theander, Elke, Noel, Wim, Zimmermann, Miriam, Shawi, May, Kollmeier, Alexa, Zabotti, Alen

“…ObjectivesPsoriatic arthritis (PsA) phenotypes are typically defined by their clinical components, which may not reflect patients’ overlapping symptoms. This…”
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P944: REAL‐WORLD PATIENT CHARACTERISTICS AND SURVIVAL OUTCOMES OF LENALIDOMIDE REFRACTORY VS. LENALIDOMIDE EXPOSED RRMM PATIENTS IN THE HONEUR FEDERATED DATA NETWORK by Spicka, Ivan, Lapidot, Ido, Merz, Maximilian, Radocha, Jakub, Stork, Martin, Jelínek, Tomas, Jungova, Alexandra, Minarik, Jiri, Soukup, Jan, Van Speybroeck, Michel, Perualila, Nolen, Diels, Joris, Duarte Mendes, João, Nimwegen, Kirsten, Strobel, Kai, Wischlen, Sebastien, Sliwka, Henrik, Gros Otero, Blanca, Hajek, Roman

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An Honeur Framework for Generating Computer Understandable Cohort Definitions from Clinical Trial Protocols in Multiple Myeloma through Generative AI for Comparing with Real-World Data by Camarrone, Flavio, van Speybroeck, Michel, Little, Linda, Scott, Hugh, Powles, Raymond

“…Background Study protocols define the population(s) of interest through a set of inclusion and exclusion criteria -often in the form of a textual description…”
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P180 Minimal disease activity response patterns in bio-naïve patients with psoriatic arthritis treated with guselkumab: a machine learning analysis by Zabotti, Alen, Ohrndorf, Sarah, Tillett, William, Neuhold, Marlies, van Speybroeck, Michel, Theander, Elke, Contré, Christine, Sharaf, Mohamed, Shawi, May, Perate, Michelle, Kollmeier, Alexa, Richette, Pascal

“…Abstract Background/Aims Guselkumab, a human monoclonal antibody targeting the interleukin-23 p19 subunit, demonstrated joint and skin efficacy in patients…”
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European Health Data & Evidence Network—learnings from building out a standardized international health data network by Voss, Erica A, Blacketer, Clair, van Sandijk, Sebastiaan, Moinat, Maxim, Kallfelz, Michael, van Speybroeck, Michel, Prieto-Alhambra, Daniel, Schuemie, Martijn J, Rijnbeek, Peter R

“…Abstract Objective Health data standardized to a common data model (CDM) simplifies and facilitates research. This study examines the factors that make…”
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Honeur (Heamatology Outcomes Network in Europe): A Federated Model to Support Real World Data Research in Hematology by Bardenheuer, Kristina, Passey, Alun, d'Errico, Maria, Millier, Barbara, Guinard-Azadian, Carine, Aschan, Johan, van Speybroeck, Michel

“…Introduction: The Haematology Outcomes Network in EURope (HONEUR) is an interdisciplinary initiative aimed at improving patient outcomes by analyzing real…”
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Patient Characteristics and Survival Outcomes of Lenalidomide Exposed non- Refractory vs. Lenalidomide Refractory Multiple Myeloma Patients in the HONEUR Federated Data Network by Hajek, Roman, Sliwka, Henrik, Stork, Martin, Spicka, Ivan, Jelinek, Tomas, Radocha, Jakub, Jungova, Alexandra, Minarik, Jiri, Soukup, Jan, Perualila, Nolen Joy, Diels, Joris, van Speybroeck, Michel, Erler-Yates, Nichola, Mendes, João, Strobel, Kai, Wischlen, Sébastien, Merz, Maximilian

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Machine Learning Provides Individualized Prediction of Outcomes after First Complete Remission in Adult AML Patients - Results from the Harmony Platform by Hernández Sánchez, Alberto, Martínez Elicegui, Javier, Sobas, Marta, Sträng, Eric, Benner, Axel, Abáigar, María, Castellani, Gastone, Tur, Laura, Valk, Peter J. M., Villaverde Ramiro, Angela, Metzeler, Klaus H, Azibeiro Melchor, Raúl, Versluis, Jurjen, Dall'Olio, Daniele, González, Teresa, Tettero, Jesse M., Martinez-Lopez, Joaquin, Fidalgo, Helena, Sierra, Jorge, Damm, Frederik, Mills, Ken I, Lehmann, Soren, Thomas, Ian, Mayer, Jiří, Thiede, Christian, Voso, Maria Teresa, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, van Speybroeck, Michel, Schulze-Rath, Renate, Barbus, Martje, Butler, John E, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

“…Background: Acute myeloid leukemia (AML) is a heterogeneous disease with high disease-related mortality and allogeneic hematopoietic stem cell transplantation…”
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Machine Learning Allows the Identification of New Co-Mutational Patterns with Prognostic Implications in NPM1 Mutated AML - Results of the European Harmony Alliance by Hernández Sánchez, Alberto, Villaverde Ramiro, Angela, Sträng, Eric, Gastone, Castellani, Heckman, Caroline A., Versluis, Jurjen, Abáigar, María, Sobas, Marta Anna, Azibeiro Melchor, Raúl, Benner, Axel, Valk, Peter JM, Metzeler, Klaus H., González, Teresa, Dall'Olio, Daniele, Tettero, Jesse M., Martinez Elicegui, Javier, Martínez-López, Joaquín, Pratcorona, Marta, Damm, Frederik, Mills, Ken I, Thiede, Christian, Voso, Maria Teresa, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Villoria Medina, Rubén, van Speybroeck, Michel, Schulze-Rath, Renate, Barbus, Martje, Butler, John E, Hernández-Rivas, Jesús María, Huntly, Brian James Patrick, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

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Harmony Alliance Provides a Machine Learning Researching Tool to Predict the Risk of Relapse after First Remission in AML Patients Treated without Allogeneic Haematopoietic Stem Cell Transplantation by Sobas, Marta, Martinez Elicegui, Javier, Villaverde Ramiro, Angela, González, Teresa, Hernandez-Sanchez, Alberto, Azibeiro Melchor, Raúl, Benner, Axel, Sträng, Eric, Gastone, Castellani, Heckman, Caroline A., Heredia Casanoves, Ana, Versluis, Jurjen, Abáigar, María, Jamilis, Laura, Valk, Peter JM, Metzeler, Klaus H., Ayala, Rosa, Martinez Lopez, Joaquin, Dombret, Hervé, Sierra, Jorge, Preudomme, Claude, Damm, Frederick, Mills, Ken I, Mayer, Jiří, Thiede, Christian, Voso, Maria Teresa, Amadori, Sergio, Sanz, Guillermo, Calado, Frederico, Döhner, Konstanze, Gaidzik, Verena I, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Villoria Medina, Rubén, Van Speybroeck, Michel, Schulze-Rath, Renate, Butler, John E, Huntly, Brian J.P, Dohner, Hartmut, Ossenkoppele, Gert J., Bullinger, Lars, Hernández-Rivas, Jesus Maria

“…Background: The decision to perform allogeneic haematopoietic stem cell transplantation (alloHSCT) in acute myeloid leukemia (AML) is based on the risk-benefit…”
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Impact of Gender on Molecular AML Subclasses - a Harmony Alliance Study by Matteuzzi, Tommaso, Dall'Olio, Daniele, Sträng, Eric, Merlotti, Alessandra, Elicegui, Javier Martinez, Benner, Axel, Saadati, Maral, Krzykalla, Julia, Heckman, Caroline A., Heredia Casanoves, Ana, Versluis, Jurjen, Abáigar, María, Hernandez-Sanchez, Alberto, Jamilis, Laura, Valk, Peter JM, Metzeler, Klaus H., Ayala, Rosa, Martinez Lopez, Joaquin, Dombret, Herve, Montesinos, Pau, Sierra, Jorge, Preudomme, Claude, Damm, Frederick, Mills, Ken I, Azibeiro Melchor, Raúl, Mayer, Jiří, Thiede, Christian, Voso, Maria Teresa, Amadori, Sergio, Sanz, Guillermo, Calado, Frederico, Döhner, Konstanze, Gaidzik, Verena I, Heuser, Michael, Haferlach, Torsten, Sobas, Marta, Turki, Amin T., Reinhardt, Dirk, Villoria Medina, Rubén, van Speybroeck, Michel, Schulze-Rath, Renate, Hernández Rivas, Jesús M, Huntly, Brian J.P, Döhner, Hartmut, Ossenkoppele, Gert J., Gastone, Castellani, Bullinger, Lars

“…The large acute myeloid leukemia (AML) patient-derived data sets collected within the European HARMONY alliance allows to study the molecular heterogeneity…”
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Does RAD21 Co-Mutation Have a Role in DNMT3A Mutated AML? Results of Harmony Alliance AML Database by Azibeiro Melchor, Raúl, Hernández Sánchez, Alberto, González, Teresa, Sobas, Marta, Martinez Elicegui, Javier, Villaverde Ramiro, Angela, Benner, Axel, Sträng, Eric, Gastone, Castellani, Heckman, Caroline A., Heredia Casanoves, Ana, Versluis, Jurjen, Abáigar, María, Jamilis, Laura, Valk, Peter JM, Metzeler, Klaus H., Ayala, Rosa, Dombret, Herve, Sierra, Jorge, Preudomme, Claude, Damm, Frederick, Mills, Ken I, Mayer, Jiří, Thiede, Christian, Voso, Maria Teresa, Amadori, Sergio, Sanz, Guillermo, Calado, Frederico, Döhner, Konstanze, Gaidzik, Verena I, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Villoria Medina, Rubén, van Speybroeck, Michel, Schulze-Rath, Renate, Butler, John E, Huntly, Brian J.P, Hernández Rivas, Jesús M, Bullinger, Lars, Döhner, Hartmut, Ossenkoppele, Gert J.

“…Background: The development of new genetic profiling techniques such as Next Generation Sequencing (NGS) have helped to unravel the genomic landscape of a…”
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Nine Principles of Semantic Harmonization by Cunningham, James A, Van Speybroeck, Michel, Kalra, Dipak, Verbeeck, Rudi

“…Medical data is routinely collected, stored and recorded across different institutions and in a range of different formats. Semantic harmonization is the…”
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Intravenous infusion route in maternal resuscitation: a scoping review by Nakamura, Eishin, Takahashi, Shinji, Matsunaga, Shigetaka, Tanaka, Hiroaki, Furuta, Marie, Sakurai, Atsushi

“…The concept that upper extremities can be used as an infusion route during cardiopulmonary resuscitation in pregnant women is a reasonable recommendation…”
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The European medical information framework: A novel ecosystem for sharing healthcare data across Europe by Lovestone, Simon

“…Introduction The European medical information framework (EMIF) was an Innovative Medicines Initiative project jointly supported by the European Union and the…”
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