Search Results - "Van Slyke, Greta"

Endpoint and epitope-specific antibody responses as correlates of vaccine-mediated protection of mice against ricin toxin by Slyke, Greta Van, Ehrbar, Dylan J., Doering, Jennifer, Yates, Jennifer L., Vitetta, Ellen S., Donini, Oreola, Mantis, Nicholas J.

“…The successful licensure of vaccines for biodefense is contingent upon the availability of well-established correlates of protection (CoP) in at least two…”
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Cooperative interactions in the West Nile virus mutant swarm by Ciota, Alexander T, Ehrbar, Dylan J, Van Slyke, Greta A, Willsey, Graham G, Kramer, Laura D

“…RNA viruses including arthropod-borne viruses (arboviruses) exist as highly genetically diverse mutant swarms within individual hosts. A more complete…”
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Exposure to West Nile Virus Increases Bacterial Diversity and Immune Gene Expression in Culex pipiens by Zink, Steven D, Van Slyke, Greta A, Palumbo, Michael J, Kramer, Laura D, Ciota, Alexander T

“…Complex interactions between microbial residents of mosquitoes and arboviruses are likely to influence many aspects of vectorial capacity and could potentially…”
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Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit by Rong, Yinghui, Van Slyke, Greta, Vance, David J, Westfall, Jennifer, Ehrbar, Dylan, Mantis, Nicholas J

“…Ricin toxin's binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of…”
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Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes by Van Slyke, Greta A, Arnold, Jamie J, Lugo, Alex J, Griesemer, Sara B, Moustafa, Ibrahim M, Kramer, Laura D, Cameron, Craig E, Ciota, Alexander T

“…High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are…”
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The evolution of virulence of West Nile virus in a mosquito vector: implications for arbovirus adaptation and evolution by Ciota, Alexander T, Ehrbar, Dylan J, Matacchiero, Amy C, Van Slyke, Greta A, Kramer, Laura D

“…Virulence is often coupled with replicative fitness of viruses in vertebrate systems, yet the relationship between virulence and fitness of arthropod-borne…”
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Mutagen resistance and mutation restriction of St. Louis encephalitis virus by Griesemer, Sara B, Kramer, Laura D, Van Slyke, Greta A, Pata, Janice D, Gohara, David W, Cameron, Craig E, Ciota, Alexander T

“…The error rate of the RNA-dependent RNA polymerase (RdRp) of RNA viruses is important in maintaining genetic diversity for viral adaptation and fitness…”
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Serological Analysis Identifies Consequential B Cell Epitopes on the Flexible Linker and C-Terminus of Decorin Binding Protein A (DbpA) from Borrelia burgdorferi by Movahed, Elaheh, Vance, David J., Ehrbar, Dylan, Van Slyke, Greta, Yates, Jennifer, Kullas, Karen, Rudolph, Michael, Mantis, Nicholas J.

“…Decorin binding protein A (DbpA) is a surface adhesin of Borrelia burgdorferi, the causative agent of Lyme disease. While DbpA is one of the most immunogenic…”
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Development and Characterization of Stable Sediment-Free Anaerobic Bacterial Enrichment Cultures That Dechlorinate Aroclor 1260 by Bedard, Donna L, Bailey, Jessica J, Reiss, Brandon L, Van Slyke Jerzak, Greta

“…We have developed sediment-free anaerobic enrichment cultures that dechlorinate a broad spectrum of highly chlorinated polychlorinated biphenyls (PCBs). The…”
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Assessment of Sample Pooling for Clinical SARS-CoV-2 Testing by Griesemer, Sara B, Van Slyke, Greta, St George, Kirsten

“…Accommodating large increases in sample workloads has presented a major challenge to clinical laboratories during the coronavirus disease 2019 (COVID-19)…”
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Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing by Griesemer, Sara B, Van Slyke, Greta, Ehrbar, Dylan, Strle, Klemen, Yildirim, Tugba, Centurioni, Dominick A, Walsh, Anne C, Chang, Andrew K, Waxman, Michael J, St George, Kirsten

“…Identifying SARS-CoV-2 infections through aggressive diagnostic testing remains critical to tracking and curbing the spread of the COVID-19 pandemic…”
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Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine by Westfall, Jennifer, Yates, Jennifer L., Van Slyke, Greta, Ehrbar, Dylan, Measey, Thomas, Straube, Richard, Donini, Oreola, Mantis, Nicholas J.

“…Biodefense vaccine are destined to be stockpiled for periods of time and deployed in the event of a public health emergency. In this report, we compared the…”
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Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge by Van Slyke, Greta, Sully, Erin K, Bohorova, Natasha, Bohorov, Ognian, Kim, Do, Pauly, Michael H, Whaley, Kevin J, Zeitlin, Larry, Mantis, Nicholas J

“…PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of…”
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Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants by Bajoria, Sakshi, Kaur, Kawaljit, Kumru, Ozan S., Van Slyke, Greta, Doering, Jennifer, Novak, Hayley, Rodriguez Aponte, Sergio A., Dalvie, Neil C., Naranjo, Christopher A., Johnston, Ryan S., Silverman, Judith Maxwell, Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end,…”
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Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD) by Kumru, Ozan S., Bajoria, Sakshi, Kaur, Kawaljit, Hickey, John M., Van Slyke, Greta, Doering, Jennifer, Berman, Katherine, Richardson, Charles, Lien, Hans, Kleanthous, Harry, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Second-generation COVID-19 vaccines with improved immunogenicity (e.g., breadth, duration) and availability (e.g., lower costs, refrigerator stable) are needed…”
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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018[sup.TM] Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen by Bajoria, Sakshi, Kumru, Ozan S, Doering, Jennifer, Berman, Katherine, Slyke, Greta Van, Prigodich, Anneka, Rodriguez-Aponte, Sergio A, Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J, Joshi, Sangeeta B, Volkin, David B

“…Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are…”
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Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques by Roy, Chad J., Ehrbar, Dylan, Van Slyke, Greta, Doering, Jennifer, Didier, Peter J., Doyle-Meyers, Lara, Donini, Oreola, Vitetta, Ellen S., Mantis, Nicholas J.

“…Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema, neutrophil…”
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Geographic and Ecological Diversity of Green Sulfur Bacteria in Hot Spring Mat Communities by Bedard, Donna L, Van Slyke, Greta, Nübel, Ulrich, Bateson, Mary M, Brumfield, Sue, An, Yong Jun, Becraft, Eric D, Wood, Jason M, Thiel, Vera, Ward, David M

“…Three strains of thermophilic green sulfur bacteria (GSB) are known; all are from microbial mats in hot springs in Rotorua, New Zealand (NZ) and belong to the…”
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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen by Bajoria, Sakshi, Kumru, Ozan S., Doering, Jennifer, Berman, Katherine, Slyke, Greta Van, Prigodich, Anneka, Rodriguez-Aponte, Sergio A., Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are…”
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Quantification of intrahost bottlenecks of West Nile virus in Culex pipiens mosquitoes using an artificial mutant swarm by Ciota, Alexander T., Ehrbar, Dylan J., Van Slyke, Greta A., Payne, Anne F., Willsey, Graham G., Viscio, Rachael E., Kramer, Laura D.

“…► An artificial mutant swarm of neutral West Nile virus variants was created. ► Changes to mutant swarm breadth in Culexpipiens were tracked over time and…”
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