Search Results - "Van Sebille, Ysabella Z.A"

Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction by Wardill, Hannah R., Mander, Kimberley A., Van Sebille, Ysabella Z.A., Gibson, Rachel J., Logan, Richard M., Bowen, Joanne M., Sonis, Stephen T.

“…Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic…”
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ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis by Van Sebille, Ysabella Z.A, Gibson, Rachel J, Wardill, Hannah R, Bowen, Joanne M

“…Highlights • The mechanisms of ErbB TKI-induced diarrhoea are likely different to chemotherapy. • This paper provides rationale for chloride secretion as a…”
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Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis by Wardill, Hannah R., Van Sebille, Ysabella Z.A., Ciorba, Matthew A., Bowen, Joanne M.

“…PURPOSE OF REVIEWStrong preclinical data support prophylactic probiotics as an effective preventive strategy for diarrhoea secondary to anticancer therapies…”
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TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea by Wardill, Hannah R, Bowen, Joanne M, Van Sebille, Ysabella Z A, Secombe, Kate R, Coller, Janet K, Ball, Imogen A, Logan, Richard M, Gibson, Rachel J

“…We have previously shown increased intestinal permeability, to 4-kDa FITC-dextran, in BALB/c mice treated with irinotecan. Importantly, genetic deletion of…”
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Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols by Secombe, Kate R., Al-Qadami, Ghanyah H., Subramaniam, Courtney B., Bowen, Joanne M., Scott, Jacqui, Van Sebille, Ysabella Z.A., Snelson, Matthew, Cowan, Caitlin, Clarke, Gerard, Gheorghe, Cassandra E., Cryan, John F., Wardill, Hannah R.

“…Fecal microbiota transplant (FMT) is a powerful tool used to connect changes in gut microbial composition with a variety of disease states and pathologies…”
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Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model by Gibson, Rachel J, van Sebille, Ysabella Z A, Wardill, Hannah R, Wignall, Anthony, Shirren, Joseph, Ball, Imogen A, Williams, Nicole, Wanner, Kiara, Bowen, Joanne M

“…The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly…”
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Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer by Van Sebille, Ysabella Z.A., Gibson, Rachel J., Wardill, Hannah R., Bowen, Joanne M.

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Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities by Wardill, Hannah R, Van Sebille, Ysabella Z.A, Mander, Kimberley A, Gibson, Rachel J, Logan, Richard M, Bowen, Joanne M, Sonis, Stephen T

“…Highlights • Regimen-related toxicities exhibit symptom clusters indicative of common biology. • Neuropathy and GI toxicity are dose-limiting side effects of…”
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Editorial Comment: Does gut-derived inflammation enhance pain signaling following chemotherapy in a Toll-like receptor 4-dependent manner? by Wardill, Hannah R., Van Sebille, Ysabella Z.A., Bowen, Joanne M., Gibson, Rachel J.

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Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms by Wardill, Hannah R, Gibson, Rachel J, Van Sebille, Ysabella Z A, Secombe, Kate R, Coller, Janet K, White, Imogen A, Manavis, Jim, Hutchinson, Mark R, Staikopoulos, Vasiliki, Logan, Richard M, Bowen, Joanne M

“…Strong epidemiological data indicate that chemotherapy-induced gut toxicity and pain occur in parallel, indicating common underlying mechanisms. We have…”
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Highlight article: Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity by Van Sebille, Ysabella ZA, Gibson, Rachel J, Wardill, Hannah R, Carney, Thomas J, Bowen, Joanne M

“…Gastrointestinal toxicity arising from cancer treatment remains a key reason for treatment discontinuation, significantly compromising remission. There are…”
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Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines by Bowen, Joanne M., Gibson, Rachel J., Coller, Janet K., Blijlevens, Nicole, Bossi, Paolo, Al-Dasooqi, Noor, Bateman, Emma H., Chiang, Karen, de Mooij, Charlotte, Mayo, Bronwen, Stringer, Andrea M., Tissing, Wim, Wardill, Hannah R., van Sebille, Ysabella Z. A., Ranna, Vinisha, Vaddi, Anusha, Keefe, Dorothy MK, Lalla, Rajesh V., Cheng, Karis Kin Fong, Elad, Sharon

“…Purpose The aim of this study was to update the clinical practice guidelines for the use of agents for the prevention and/or treatment of gastrointestinal…”
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Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics by Van Sebille, Ysabella Z. A., Stansborough, Romany, Wardill, Hannah R., Bateman, Emma, Gibson, Rachel J., Keefe, Dorothy M.

“…Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which…”
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Diarrhea Induced by Small Molecule Tyrosine Kinase Inhibitors Compared With Chemotherapy: Potential Role of the Microbiome by Secombe, Kate R., Van Sebille, Ysabella Z. A., Mayo, Bronwen J., Coller, Janet K., Gibson, Rachel J., Bowen, Joanne M.

“…Small molecule receptor tyrosine kinase inhibitors (SM-TKIs) are among a group of targeted cancer therapies, intended to be more specific to cancer cells…”
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Dacomitinib‐induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats by Van Sebille, Ysabella Z.A., Gibson, Rachel J., Wardill, Hannah R., Secombe, Kate R., Ball, Imogen A., Keefe, Dorothy M.K., Finnie, John W., Bowen, Joanne M.

“…Dacomitinib—an irreversible pan‐ErbB tyrosine kinase inhibitor (TKI)—causes diarrhoea in 75% of patients. Dacomitinib‐induced diarrhoea has not previously been…”
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Dacomitinib‐induced diarrhea: Targeting chloride secretion with crofelemer by Van Sebille, Ysabella Z.A., Gibson, Rachel J., Wardill, Hannah R., Ball, Imogen A., Keefe, Dorothy M.K., Bowen, Joanne M.

“…Dacomitinib, an irreversible small‐molecule pan‐ErbB TKI, has a high incidence of diarrhea, which has been suggested to be due to chloride secretory…”
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Toll-like receptor 4 signaling: a common biological mechanism of regimen-related toxicities: an emerging hypothesis for neuropathy and gastrointestinal toxicity by Wardill, Hannah R, Van Sebille, Ysabella Z A, Mander, Kimberley A, Gibson, Rachel J, Logan, Richard M, Bowen, Joanne M, Sonis, Stephen T

“…Regimen-related toxicities remain a priority concern within the field of supportive care in cancer. Despite this, many forms of toxicity are under reported and…”
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Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer by Wardill, Hannah R., Logan, Richard M., Bowen, Joanne M., Van Sebille, Ysabella Z. A., Gibson, Rachel J.

“…Purpose Oral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can…”
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A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options by Wardill, Hannah R, Gibson, Rachel J, Van Sebille, Ysabella ZA, Secombe, Kate R, Logan, Richard M, Bowen, Joanne M

“…Tight junction and epithelial barrier disruption is a common trait of many gastrointestinal pathologies, including chemotherapy-induced gut toxicity…”
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Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report by Coller, Janet K., Bowen, Joanne M., Ball, Imogen A., Wardill, Hannah R., van Sebille, Ysabella Z. A., Stansborough, Romany L., Lightwala, Zenab, Wignall, Anthony, Shirren, Joseph, Secombe, Kate, Gibson, Rachel J.

“…Purpose Irinotecan-induced gut toxicity is mediated in part by Toll-Like receptor 4 (TLR4) signalling. The primary purpose of this preclinical study was to…”
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