Search Results - "Van Ryn, J."

Rapid determination of anticoagulating effects of dabigatran in whole blood with rotational thromboelastometry and a thrombin‐based trigger by Taune, V., Skeppholm, M., Ågren, A., Gryfelt, G., Malmström, R. E., Wikman, A., Van Ryn, J., Wallén, H.

“…Essentials A rapid test to detect thrombin inhibition by dabigatran would be valuable in acute situations. A thrombin‐based trigger was applied in whole blood…”
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Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples by Postnikova, Elena N, Pettitt, James, Van Ryn, Collin J, Holbrook, Michael R, Bollinger, Laura, Yú, Shuǐqìng, Caì, Yíngyún, Liang, Janie, Sneller, Michael C, Jahrling, Peter B, Hensley, Lisa E, Kuhn, Jens H, Fallah, Mosoka P, Bennett, Richard S, Reilly, Cavan

“…Antibody titers against a viral pathogen are typically measured using an antigen binding assay, such as an enzyme-linked immunosorbent assay (ELISA), which…”
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Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model by PRAGST, I., ZEITLER, S. H., DOERR, B., KASPEREIT, F. J., HERZOG, E., DICKNEITE, G., van RYN, J.

“…Background:  One limitation of the direct thrombin inhibitor dabigatran is the lack of specific antidotes that allow acute bleeding events to be managed or…”
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The addition of idarucizumab to plasma samples containing dabigatran allows the use of routine coagulation assays for the diagnosis of hemostasis disorders by Jacquemin, M., Toelen, J., Schoeters, J., van Horenbeeck, I., Vanlinthout, I., Debasse, M., Peetermans, M., Vanassche, T., Peerlinck, K., Ryn, J., Verhamme, P.

“…Summary Background The anticoagulant effect of dabigatran can be approximated by its prolongation of routine coagulation assays. Consequently, dabigatran also…”
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Efficacy of idarucizumab, prothrombin complex concentrate (PCC) and activated PCC to reverse the anticoagulatory potential of dabigatran in a porcine polytrauma model by Honickel, M, Braunschweig, T, Ryn, J Van, Rossaint, R, Grottke, O

“…[...]the impact on clinical parameters such as blood loss is not known. [...]this study assessed the efficacy of idarucizumab in comparison with PCC and aPCC…”
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In a trauma experimental pig model prothrombin complex concentrates and a specific antidote (idarucizumab) are effective to reverse the anticoagulant effects of dabigatran by Grottke, O, Van Ryn, J, Rossaint, R

“…Keywords: Dabigatran, Clot Formation, Anticoagulant Effect, Dabigatran Etexilate, Total Blood Loss…”
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Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence by VANASSCHE, T., VERHAEGEN, J., PEETERMANS, W. E., VAN RYN, J., CHENG, A., SCHNEEWIND, O., HOYLAERTS, M. F., VERHAMME, P.

“…Background: Staphylocoagulase and von Willebrand binding protein (VWbp) bind to prothrombin to form the staphylothrombin complex that converts fibrinogen into…”
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Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer by Pairet, M, van Ryn, J, Schierok, H, Mauz, A, Trummlitz, G, Engelhardt, G

“…Two structurally related compounds, meloxicam (Mel) and its structural 4'-isomer (4'-Mel), were compared to examine the role of a slightly different chemical…”
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Prothrombin complex concentrate restores haemostasis in a dabigatran anticoagulated polytrauma pig model by Honickel, M, Van Ryn, J, Spronk, HM, Ten Cate, H, Rossaint, R, Grottke, O

“…Keywords: Blood Loss, Thrombin, Dabigatran, Femur Fracture, Anticoagulant Effect…”
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Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs by Pairet, M, van Ryn, J

“…Numerous in vitro assays have been developed for testing and comparing the relative inhibitory activities of non-steroidal anti-inflammatory drugs against…”
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PO-82 Dabigatran etexilate blocks breast cancer progression in vitro and in a 4T1 breast cancer tumor model in mice by DeFeo, K, Hayes, C, van Ryn, J, Gilmour, S.K

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OC-04 Expression of protease activated receptor-1 and tissue factor in human cancers determined by gene expression profiling and laser capture microdissection by Haslinger, C, Rupp, C, Dolznig, H, Schweifer, N, van Ryn, J, Garin-Chesa, P

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Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E2 synthesis in rat microglial cells by FIEBICH, B. L, LIEB, K, HÜLL, M, AICHER, B, VAN RYN, J, PAIRET, M, ENGELHARDT, G

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Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E 2 synthesis in rat microglial cells by Fiebich, B.L., Lieb, K., Hüll, M., Aicher, B., van Ryn, J., Pairet, M., Engelhardt, G.

“…Paracetamol has mild analgesic and antipyretic properties and is, along with acetylsalicylic acid, one of the most popular “over the counter” analgesic agents…”
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Clinical experience with cyclooxygenase-2 inhibitors by van Ryn, J, Pairet, M

“…Increasing amounts of experimental and clinical data support the role of selective cyclooxygenase (COX)-2 inhibition in anti-inflammatory processes and the…”
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A comparison of the thrombolytic and hemorrhagic effects of tissue-type plasminogen activator and streptokinase in rabbits by AGNELLI, G, BUCHANAN, M. R, FERNANDEZ, F, BONEU, B, VAN RYN, J, HIRSH, J, COLLEN, D

“…Tissue-type plasminogen activator (t-PA) is a promising thrombolytic agent because it can produce thrombolysis without inducing a plasma proteolytic state. It…”
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A specific antidote for dabigatran: functional and structural characterization by Schiele, Felix, van Ryn, Joanne, Canada, Keith, Newsome, Corey, Sepulveda, Eliud, Park, John, Nar, Herbert, Litzenburger, Tobias

“…Dabigatran etexilate is a direct thrombin inhibitor and used widely as an anticoagulant for the prevention of stroke in patients with atrial fibrillation…”
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Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity by van Ryn, Joanne, Stangier, Joachim, Haertter, Sebastian, Liesenfeld, Karl-Heinz, Wienen, Wolfgang, Feuring, Martin, Clemens, Andreas

“…Dabigatran etexilate is an oral, reversible direct thrombin inhibitor that is approved in the EU and several other countries for the prevention of venous…”
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Endothelial cells produce a lipoxygenase derived chemo-repellent which influences platelet/endothelial cell interactions--effect of aspirin and salicylate by Buchanan, M R, Butt, R W, Magas, Z, van Ryn, J, Hirsh, J, Nazir, D J

“…We performed experiments to determine whether endothelial cells synthesize phospholipid metabolites via the lipoxygenase pathway and whether these metabolites…”
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The effects of heparin and annexin V on fibrin accretion after injury in the jugular veins of rabbits by Van Ryn-McKenna, J, Merk, H, Müller, T H, Buchanan, M R, Eisert, W G

“…We compared the relative abilities of unfractionated heparin and annexin V to prevent fibrin accretion onto injured jugular veins in vivo. Heparin was used to…”
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