Search Results - "Van Rompaey, Luc"

Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method by Flieswasser, Tal, Camara-Clayette, Valérie, Danu, Alina, Bosq, Jacques, Ribrag, Vincent, Zabrocki, Piotr, Van Rompaey, Luc, de Haard, Hans, Zwaenepoel, Karen, Smits, Evelien, Pauwels, Patrick, Jacobs, Julie

“…The constitutive expression of CD70 has been described in various haematological and solid tumour types. In addition, the co-expression of its receptor in…”
Get full text

Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies by Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Offner, Fritz, Bron, Dominique, Maerevoet, Marie, Soria, Jean-Charles, Moshir, Mahan, Dreier, Torsten, Van Rompaey, Luc, Michot, Jean-Marie, Silence, Karen, Hultberg, Anna, Gandini, Domenica, de Haard, Hans, Ribrag, Vincent, Peeters, Marc, Thibault, Alain, Leupin, Nicolas, Awada, Ahmad

“…The purpose of this study was to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor efficacy of ARGX-110, a glyco-engineered…”
Get full text

Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents by Riether, Carsten, Pabst, Thomas, Höpner, Sabine, Bacher, Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid H., Francisco, David, Bruggmann, Remy, van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, de Haard, Hans, Leupin, Nicolas, Ochsenbein, Adrian F.

“…Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist conventional chemotherapy and are the major cause of relapse 1 , 2 …”
Get full text

Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases by Van Rompaey, Luc, Galien, René, van der Aar, Ellen M, Clement-Lacroix, Philippe, Nelles, Luc, Smets, Bart, Lepescheux, Liên, Christophe, Thierry, Conrath, Katja, Vandeghinste, Nick, Vayssiere, Béatrice, De Vos, Steve, Fletcher, Stephen, Brys, Reginald, van 't Klooster, Gerben, Feyen, Jean H M, Menet, Christel

“…The JAKs receive continued interest as therapeutic targets for autoimmune, inflammatory, and oncological diseases. JAKs play critical roles in the development…”
Get full text

Cusatuzumab for treatment of CD70‐positive relapsed or refractory cutaneous T‐cell lymphoma by Leupin, Nicolas, Zinzani, Pier Luigi, Morschhauser, Franck, Dalle, Stéphane, Maerevoet, Marie, Michot, Jean‐Marie, Ribrag, Vincent, Offner, Fritz, Beylot‐Barry, Marie, Moins‐Teisserenc, Hélène, Zwaenepoel, Karen, Winne, Koen, Battistella, Maxime, Hultberg, Anna, Gandini, Domenica, Moshir, Mahan, Jacobs, Julie, Delahaye, Tim, Khan, Aitzaz, Zabrocki, Piotr, Silence, Karen, Rompaey, Luc, Borg, Christophe, Motta, Giovanna, Melle, Federica, Calleri, Angelica, Pauwels, Patrick, Haard, Hans, Pileri, Stefano, Bagot, Martine

“…Background The clinical benefit of cusatuzumab, a CD70‐directed monoclonal antibody with enhanced effector functions, was investigated in patients with…”
Get full text

Advances in the discovery of selective JAK inhibitors by Menet, Christel J, Rompaey, Luc Van, Geney, Raphaël

“…In this review, we describe the current knowledge of the biology of the JAKs. The JAK family comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3,…”
Get more information

The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients by Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S., Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad

“…Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor…”
Get full text

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes by Schwaller, Juerg, Frantsve, Julie, Aster, Jon, Williams, Ifor R., Tomasson, Michael H., Ross, Theodora S., Peeters, Pieter, Van Rompaey, Luc, Van Etten, Richard A., Ilaria Jr, Robert, Marynen, Peter, Gilliland, D.Gary

“…Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the…”
Get full text

Arrayed adenoviral expression libraries for functional screening by van Es, Helmuth, Michiels, Frits, van Rompaey, Luc, Merchiers, Pascal, Francken, Bart, Pittois, Karen, van der Schueren, Jan, Brys, Reginald, Vandersmissen, Johan, Beirinckx, Filip, Herman, Sofie, Dokic, Kristina, Klaassen, Hugo, Narinx, Evi, Hagers, Annick, Laenen, Wendy, Piest, Ivo, Pavliska, Heidi, Rombout, Yvonne, Langemeijer, Ellen, Ma, Libin, Schipper, Christel, Raeymaeker, Marc De, Schweicher, Stephane, Jans, Mia, van Beeck, Kris, Tsang, Ing-Ren, van de Stolpe, Onno, Tomme, Peter

“…With the publication of the sequence of the human genome, we are challenged to identify the functions of an estimated 70,000 human genes and the much larger…”
Get full text

The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity by Buijs, Arjan, van Rompaey, Luc, Molijn, Anco C., Davis, J. Nathan, Vertegaal, Alfred C. O., Potter, Mark D., Adams, Constantin, van Baal, Sjozèf, Zwarthoff, Ellen C., Roussel, Martine F., Grosveld, Gerard C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Anti-CD70 Monoclonal Antibodies Show Efficacy in Preclinical Models for Chronic Lymphoblastic Leukemia by Chen, Shih-Shih, Yan, Xiao-Jie, Van Rompaey, Luc, Zabrocki, Piotr, Chiorazzi, Nicholas

Get full text

Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 by Menet, Christel J, Fletcher, Stephen R, Van Lommen, Guy, Geney, Raphael, Blanc, Javier, Smits, Koen, Jouannigot, Nolwenn, Deprez, Pierre, van der Aar, Ellen M, Clement-Lacroix, Philippe, Lepescheux, Liên, Galien, René, Vayssiere, Béatrice, Nelles, Luc, Christophe, Thierry, Brys, Reginald, Uhring, Muriel, Ciesielski, Fabrice, Van Rompaey, Luc

“…Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway…”
Get full text

Corrigendum: Arrayed adenoviral expression libraries for functional screening by Michiels, Frits, van Es, Helmuth, van Rompaey, Luc, Merchiers, Pascal, Francken, Bart, Pittois, Karen, van der Schueren, Jan, Brys, Reginald, Vandersmissen, Johan, Beirinckx, Filip, Herman, Sofie, Dokic, Kristina, Klaassen, Hugo, Narinx, Evi, Hagers, Annick, Laenen, Wendy, Piest, Ivo, Pavliska, Heidi, Rombout, Yvonne, Langemeijer, Ellen, Ma, Libin, Schipper, Christel, De Raeymaeker, Marc, Schweicher, Stephane, Jans, Mia, van Beeck, Kris, Tsang, Ing-Ren, van de Stolpe, Onno, Tomme, Peter

Get full text

Generic design principles for antibody-based tumour necrosis factor (TNF) receptor 2 (TNFR2) agonists with FcγR-independent agonism by Anany, Mohamed A, Haack, Stefanie, Lang, Isabell, Dahlhoff, Julia, Vargas, Juan Gamboa, Steinfatt, Tim, Päckert, Lea, Weisenberger, Daniela, Zaitseva, Olena, Medler, Juliane, Kucka, Kirstin, Zhang, Tengyu, Van Belle, Tom, van Rompaey, Luc, Beilhack, Andreas, Wajant, Harald

“…Selective TNFR2 activation can be used to treat immune pathologies by activating and expanding regulatory T-cells (Tregs) but may also restore anti-tumour…”
Get full text

Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34+ AML Stem and Progenitor Cells in Vitro and In Vivo by Hinterbrandner, Magdalena, Kallen, Nils Maria, Lüthi, Ursina, Pabst, Thomas, Van Rompaey, Luc, Leupin, Nicolas, De Haard, Hans, Ochsenbein, Adrian F, Riether, Carsten

“…Leukemia stem cells (LSCs) are the origin of acute myeloid leukemia (AML) and are resistant to standard therapeutic regimens resulting in frequent relapse of…”
Get full text

Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans by Ochsenbein, Adrian F, Pabst, Thomas, Höpner, Sabine, Bacher, Vera Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid, Francisco, David, Bruggmann, Rémy, Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Riether, Carsten

“…▪ Introduction Acute myeloid leukemia (AML) is a heterogenous hematological malignancy driven by leukemia stem cells (LSCs) (Lapidot et al, 1994). LSCs…”
Get full text

Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial by Ochsenbein, Adrian F, Riether, Carsten, Bacher, Ulrike, Müller, Rouven, Höpner, Sabine, Banz, Yara, Hinterbrandner, Magdalena, Bargetzi, Mario, Manz, Markus G., Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Pabst, Thomas

“…Outcomes in elderly patients with acute myeloid leukemia (AML) are still adverse, as the majority does not qualify for intensive therapy or allogenic stem cell…”
Get full text

Argx-110 for Treatment of CD70-Positive Advanced Cutaneous T-Cell Lymphoma in a Phase 1/2 Clinical Trial by Bagot, Martine, Maerevoet, Marie, Zinzani, Pier Luigi, Offner, Fritz, Morschhauser, Franck, Michot, Jean-Marie, Ribrag, Vincent, Battistella, Maxime, Moins, Helene, Calleri, Angelica, Dalle, Stéphane, Beylot-Barry, Marie, Zwaenepoel, Karen, De Winnie, Koen, Marie-Cardine, Anne, Cayuela, Jean-Michel, Tabanelli, Valentina, Motta, Giovanna, Melle, Federica, Hultberg, Anna, Gandini, Domenica, Marafioti, Teresa, Moshir, Mahan, Delahaye, Tim, Zabrocki, Piotr, Silence, Karen, Van Rompaey, Luc, Bensussan, Armand, De Haard, Hans, Pauwels, Patrick, Leupin, Nicolas, Pileri, Stefano A.

“…Introduction Cutaneous T-cell lymphoma (CTCL), a heterogeneous group of rare non-Hodgkin's lymphomas, is characterized by infiltration of malignant clonally…”
Get full text

ARGX-111 shows activity in MET-amplified patients in a phase-I study and in preclinical models of myeloid-derived suppressor cell (MDSC) depletion in the tumor microenvironment by Rolfo, Christian Diego, Aftimos, Philippe Georges, Pallandre, Jean-Rene, Morello, Virginia, Bouard, Adeline, Cazzanti, Manuela, Barthelemy, Philippe, Rottey, Sylvie, Awada, Ahmad, Hanssens, Valerie, De Jonge, Natalie, Van Rompaey, Luc, Fung, Samson Sau-Sing, Michieli, Paolo, Borg, Christophe

“…Abstract only…”
Get full text

Clinical response observed in a phase I study in T cell lymphoma patients treated with anti-CD70 SIMPLE Antibody ARGX-110 by Michot, Jean-Marie, Maerevoet, Marie, Aftimos, Philippe Georges, Rottey, Sylvie, Rolfo, Christian Diego, Offner, Fritz, Van Rompaey, Luc, Moshir, Mahan, de Haard, Hans, Silence, Karen, Pauwels, Patrick, Zwaenepoel, Karen, Awada, Ahmad, Bron, Dominique, Ribrag, Vincent

“…Abstract only…”
Get full text