Search Results - "Van Ravenzwaay, Ben"

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells by Ramirez, Tzutzuy, Strigun, Alexander, Verlohner, Andreas, Huener, Hans-Albrecht, Peter, Erik, Herold, Michael, Bordag, Natalie, Mellert, Werner, Walk, Tilmann, Spitzer, Michael, Jiang, Xiaoqi, Sperber, Saskia, Hofmann, Thomas, Hartung, Thomas, Kamp, Hennicke, van Ravenzwaay, Ben

“…Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In…”
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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop by Buesen, Roland, Chorley, Brian N., da Silva Lima, Beatriz, Daston, George, Deferme, Lize, Ebbels, Timothy, Gant, Timothy W., Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H., Sauer, Ursula G., Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut E., Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J.M., Worth, Andrew, Yauk, Carole, Poole, Alan

“…Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and…”
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Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats by Fabian, Eric, Landsiedel, Robert, Ma-Hock, Lan, Wiench, Karin, Wohlleben, Wendel, van Ravenzwaay, Ben

“…The tissue distribution and toxicity of intravenously administered nanoparticles of titanium dioxide (TiO 2 ) (>10 wt.% at <100 nm size) were investigated…”
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Comparing fate and effects of three particles of different surface properties: Nano-TiO2, pigmentary TiO2 and quartz by van Ravenzwaay, Ben, Landsiedel, Robert, Fabian, Eric, Burkhardt, Silke, Strauss, Volker, Ma-Hock, Lan

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A generic Transcriptomics Reporting Framework (TRF) for ‘omics data processing and analysis by Gant, Timothy W., Sauer, Ursula G., Zhang, Shu-Dong, Chorley, Brian N., Hackermüller, Jörg, Perdichizzi, Stefania, Tollefsen, Knut E., van Ravenzwaay, Ben, Yauk, Carole, Tong, Weida, Poole, Alan

“…A generic Transcriptomics Reporting Framework (TRF) is presented that lists parameters that should be reported in ‘omics studies used in a regulatory context…”
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Framework for the quality assurance of ’omics technologies considering GLP requirements by Kauffmann, Hans-Martin, Kamp, Hennicke, Fuchs, Regine, Chorley, Brian N., Deferme, Lize, Ebbels, Timothy, Hackermüller, Jörg, Perdichizzi, Stefania, Poole, Alan, Sauer, Ursula G., Tollefsen, Knut E., Tralau, Tewes, Yauk, Carole, van Ravenzwaay, Ben

“…‘Omics technologies are gaining importance to support regulatory toxicity studies. Prerequisites for performing ‘omics studies considering GLP principles were…”
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Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes by Bridges, Jim, Sauer, Ursula G., Buesen, Roland, Deferme, Lize, Tollefsen, Knut E., Tralau, Tewes, van Ravenzwaay, Ben, Poole, Alan, Pemberton, Mark

“…A framework for the quantitative weight-of-evidence (QWoE) analysis of ‘omics data for regulatory purposes is presented. The QWoE framework encompasses seven…”
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Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations by Landsiedel, Robert, Ma-Hock, Lan, Van Ravenzwaay, Ben, Schulz, Markus, Wiench, Karin, Champ, Samantha, Schulte, Stefan, Wohlleben, Wendel, Oesch, Franz

“…Abstract Titanium dioxide and zinc oxide nanomaterials, used as UV protecting agents in sunscreens, were investigated for their potential genotoxicity in in…”
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Experience with the HET-CAM Method in the Routine Testing of a Broad Variety of Chemicals and Formulations by Schrage, Arnhild, Gamer, Armin O, Ravenzwaay, Ben van, Landsiedel, Robert

“…Data on eye irritation are generally needed for the hazard identification of chemicals. For the routine testing of a broad variety of chemicals and…”
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Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward by Landsiedel, Robert, Ma-Hock, Lan, Haussmann, Hans-Juergen, van Ravenzwaay, Ben, Kayser, Martin, Wiench, Karin

“…While technical and medical potential offered by nanotechnologies increase, the safety assessment of engineered nanomaterials (NMs) needs to follow this pace…”
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Suitability of skin integrity tests for dermal absorption studies in vitro by Guth, Katharina, Schäfer-Korting, Monika, Fabian, Eric, Landsiedel, Robert, van Ravenzwaay, Ben

“…•The study compared skin integrity tests with dermal absorption profiles.•TEER, TEWL and TWF detected a major part of impaired skin preparations.•Absorption of…”
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Toxico-/biokinetics of nanomaterials by Landsiedel, Robert, Fabian, Eric, Ma-Hock, Lan, Wohlleben, Wendel, Wiench, Karin, Oesch, Franz, van Ravenzwaay, Ben

“…Nanomaterials (NM) offer great technological advantages but their risks to human health are still under discussion. For toxicological testing and evaluation,…”
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The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook by Sauer, Ursula G., Deferme, Lize, Gribaldo, Laura, Hackermüller, Jörg, Tralau, Tewes, van Ravenzwaay, Ben, Yauk, Carole, Poole, Alan, Tong, Weida, Gant, Timothy W.

“…This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that ‘omics technologies are generally not yet applied to…”
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Adverse outcome pathways: opportunities, limitations and open questions by Leist, Marcel, Ghallab, Ahmed, Graepel, Rabea, Marchan, Rosemarie, Hassan, Reham, Bennekou, Susanne Hougaard, Limonciel, Alice, Vinken, Mathieu, Schildknecht, Stefan, Waldmann, Tanja, Danen, Erik, van Ravenzwaay, Ben, Kamp, Hennicke, Gardner, Iain, Godoy, Patricio, Bois, Frederic Y., Braeuning, Albert, Reif, Raymond, Oesch, Franz, Drasdo, Dirk, Höhme, Stefan, Schwarz, Michael, Hartung, Thomas, Braunbeck, Thomas, Beltman, Joost, Vrieling, Harry, Sanz, Ferran, Forsby, Anna, Gadaleta, Domenico, Fisher, Ciarán, Kelm, Jens, Fluri, David, Ecker, Gerhard, Zdrazil, Barbara, Terron, Andrea, Jennings, Paul, van der Burg, Bart, Dooley, Steven, Meijer, Annemarie H., Willighagen, Egon, Martens, Marvin, Evelo, Chris, Mombelli, Enrico, Taboureau, Olivier, Mantovani, Alberto, Hardy, Barry, Koch, Bjorn, Escher, Sylvia, van Thriel, Christoph, Cadenas, Cristina, Kroese, D., van de Water, Bob, Hengstler, Jan G.

“…Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic…”
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Limited applicability of in vitro skin corrosion and irritation tests for agrochemical formulations by Kolle, Susanne N., van Ravenzwaay, Ben, Landsiedel, Robert

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Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment by Najjar, Abdulkarim, Punt, Ans, Wambaugh, John, Paini, Alicia, Ellison, Corie, Fragki, Styliani, Bianchi, Enrica, Zhang, Fagen, Westerhout, Joost, Mueller, Dennis, Li, Hequn, Shi, Quan, Gant, Timothy W., Botham, Phil, Bars, Rémi, Piersma, Aldert, van Ravenzwaay, Ben, Kramer, Nynke I.

“…With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the…”
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Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies by Klein, Christoph L., Wiench, Karin, Wiemann, Martin, Ma-Hock, Lan, van Ravenzwaay, Ben, Landsiedel, Robert

“…A major health concern for nanomaterials is their potential toxic effect after inhalation of dusts. Correspondingly, the core element of tier 1 in the…”
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity by Gant, Timothy W., Auerbach, Scott S., Von Bergen, Martin, Bouhifd, Mounir, Botham, Philip A., Caiment, Florian, Currie, Richard A., Harrill, Joshua, Johnson, Kamin, Li, Dongying, Rouquie, David, van Ravenzwaay, Ben, Sistare, Frank, Tralau, Tewes, Viant, Mark R., van de Laan, Jan Willem, Yauk, Carole

“…In a joint effort involving scientists from academia, industry and regulatory agencies, ECETOC’s activities in Omics have led to conceptual proposals for: (1)…”
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The potential of protein reactivity to predict skin sensitizing potency: Of peptide depletion, reaction time and tested concentrations by Landsiedel, Robert, Kolle, Susanne N., Urbisch, Daniel, Wareing, Britta, van Ravenzwaay, Ben

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Metabolomics in vitro in kidney cells – A tool for investigation of the nephrotoxicity by Birk, Barbara, Sperber, Saskia, Huener, Hans-Albrecht, Verlohner, Andreas, Walk, Tilmann, Haake, Volker, Kamp, Hennicke, van Ravenzwaay, Ben

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