Search Results - "Van Ostrand, Robert P."

Structural Insights into the Mechanism of Base Excision by MBD4 by Pidugu, Lakshmi S., Bright, Hilary, Lin, Wen-Jen, Majumdar, Chandrima, Van Ostrand, Robert P., David, Sheila S., Pozharski, Edwin, Drohat, Alexander C.

“…[Display omitted] •DNA glycosylases remove damaged bases, initiating BER, but mechanisms for many are poorly defined.•MBD4, of the HhH superfamily, repairs…”
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Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2‑Amino Group of 8‑Oxoguanine by Lee, Andrea J, Majumdar, Chandrima, Kathe, Scott D, Van Ostrand, Robert P, Vickery, Holly R, Averill, April M, Nelson, Shane R, Manlove, Amelia H, McCord, Morgan A, David, Sheila S

“…MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and…”
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Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine by Lee, Andrea J., Majumdar, Chandrima, Kathe, Scott D., Van Ostrand, Robert P., Vickery, Holly R., Averill, April M., Nelson, Shane R., Manlove, Amelia H., McCord, Morgan A., David, Sheila S.

“…MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and…”
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