Search Results - "Van Oosterhout, Antoon J. M"

Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice by Post, Sijranke, Heijink, Irene H, Petersen, Arjen H, de Bruin, Harold G, van Oosterhout, Antoon J M, Nawijn, Martijn C

“…Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous substances that can induce allergic sensitization upon…”
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Down-Regulation of E-Cadherin in Human Bronchial Epithelial Cells Leads to Epidermal Growth Factor Receptor-Dependent Th2 Cell-Promoting Activity by Heijink, Irene H, Kies, P. Marcel, Kauffman, Henk F, Postma, Dirkje S, van Oosterhout, Antoon J. M, Vellenga, Edo

“…Airway epithelial cells are well-known producers of thymus- and activation-regulated chemokine (TARC), a Th2 cell-attracting chemokine that may play an…”
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Cigarette smoke irreversibly modifies glutathione in airway epithelial cells by van der Toorn, Marco, Smit-de Vries, Maria P, Slebos, Dirk-Jan, de Bruin, Harold G, Abello, Nicolas, van Oosterhout, Antoon J M, Bischoff, Rainer, Kauffman, Henk F

“…In patients with chronic obstructive pulmonary disease (COPD), an imbalance between oxidants and antioxidants is acknowledged to result in disease development…”
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TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice by Nawijn, Martijn C, Motta, Alexandre C, Gras, Renée, Shirinbak, Soheila, Maazi, Hadi, van Oosterhout, Antoon J M

“…Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction and airway hyperresponsiveness (AHR). The T regulatory…”
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Advanced glycation endproducts and their receptor in different body compartments in COPD by Hoonhorst, Susan J M, Lo Tam Loi, Adèle T, Pouwels, Simon D, Faiz, Alen, Telenga, Eef D, van den Berge, Maarten, Koenderman, Leo, Lammers, Jan-Willem J, Boezen, H Marike, van Oosterhout, Antoon J M, Lodewijk, Monique E, Timens, Wim, Postma, Dirkje S, Ten Hacken, Nick H T

“…Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by chronic airway inflammation and emphysema, and is caused by exposure to…”
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Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells by Somborac‐Bačura, Anita, van der Toorn, Marco, Franciosi, Lorenza, Slebos, Dirk‐Jan, Žanić‐Grubišić, Tihana, Bischoff, Rainer, van Oosterhout, Antoon J. M.

“…New findings •  What is the central question of this study? The endoplasmic reticulum stress response caused by cigarette smoke may lead to excessive apoptosis…”
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Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells by van der Toorn, Marco, Rezayat, Delaram, Kauffman, Henk F, Bakker, Stephan J L, Gans, Rijk O B, Koëter, Gerard H, Choi, Augustine M K, van Oosterhout, Antoon J M, Slebos, Dirk-Jan

“…Reactive oxygen species (ROS) present in cigarette smoke (CS) are thought to contribute to the development of COPD. Although CS-ROS can hardly enter airway…”
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Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium by ZIJLSTRA, G. Jan, FATTAHI, Fatemeh, ROZEVELD, Dennie, JONKER, Marnix R, KLIPHUIS, Nathalie M, VAN DEN BERGE, Maarten, HYLKEMA, Machteld N, TEN HACKEN, Nick H. T, VAN OOSTERHOUT, Antoon J. M, HEIJINK, Irene H

“…Th17-mediated neutrophilic airway inflammation has been implicated in decreased response to glucocorticoids in asthma. We aimed to investigate the effect of…”
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Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis by van der Toorn, Marco, Slebos, Dirk-Jan, de Bruin, Harold G, Leuvenink, Henri G, Bakker, Stephan J L, Gans, Rijk O B, Koëter, Gerard H, van Oosterhout, Antoon J M, Kauffman, Henk F

“…Increased lung cell apoptosis and necrosis occur in patients with chronic obstructive pulmonary disease (COPD). Mitochondria are crucially involved in the…”
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Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice by Pouwels, Simon D, Zijlstra, G Jan, van der Toorn, Marco, Hesse, Laura, Gras, Renee, Ten Hacken, Nick H T, Krysko, Dmitri V, Vandenabeele, Peter, de Vries, Maaike, van Oosterhout, Antoon J M, Heijink, Irene H, Nawijn, Martijn C

“…Recent data indicate a role for airway epithelial necroptosis, a regulated form of necrosis, and the associated release of damage-associated molecular patterns…”
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Critical role of aldehydes in cigarette smoke-induced acute airway inflammation by van der Toorn, Marco, Slebos, Dirk-Jan, de Bruin, Harold G, Gras, Renee, Rezayat, Delaram, Jorge, Lucie, Sandra, Koen, van Oosterhout, Antoon J M

“…Cigarette smoking (CS) is the most important risk factor for COPD, which is associated with neutrophilic airway inflammation. We hypothesize, that highly…”
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GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma by Motta, Alexandre C, Vissers, Joost L M, Gras, Renée, Van Esch, Betty C A M, Van Oosterhout, Antoon J M, Nawijn, Martijn C

“…Allergic asthma is characterized by airway hyperresponsiveness (AHR) and allergic inflammation of the airways, driven by allergen-specific Th2 cells. The…”
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Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo by Koning, Henk, van Oosterhout, Antoon J M, Brouwer, Uilke, den Boef, Lisette E, Gras, Renée, Reinders-Luinge, Marjan, Brandsma, Corry-Anke, van der Toorn, Marco, Hylkema, Machteld N, Willemse, Brigitte W M, Sayers, Ian, Koppelman, Gerard H, Nawijn, Martijn C

“…Protocadherin-1 (PCDH1) is a novel susceptibility gene for airway hyperresponsiveness, first identified in families exposed to cigarette smoke and is expressed…”
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Indoleamine 2,3-dioxygenase–dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model by Taher, Yousef A., MSc, Piavaux, Benoit J.A., MSc, Gras, Reneé, BSc, van Esch, Betty C.A.M., BSc, Hofman, Gerard A., BSc, Bloksma, Nanne, PhD, Henricks, Paul A.J., PhD, van Oosterhout, Antoon J.M., PhD

“…Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in immune suppression and tolerance induction. Objective We…”
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Untargeted Lipidomic Analysis in Chronic Obstructive Pulmonary Disease: Uncovering Sphingolipids by TELENGA, Eef D, HOFFMANN, Roland F, POSTMA, Dirkje S, SANDRA, Koen, TEN HACKEN, Nick H. T, T'KINDT, Ruben, HOONHORST, Susan J. M, WILLEMSE, Brigitte W. M, VAN OOSTERHOUT, Antoon J. M, HEIJINK, Irene H, VAN DEN BERGE, Maarten, JORGE, Lucie, SANDRA, Pat

“…Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field…”
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MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation by Matusiak, Nathalie, van Waarde, Aren, Rozeveld, Dennie, van Oosterhout, Antoon J. M., Heijink, Irene H., Castelli, Riccardo, Overkleeft, Herman S., Bischoff, Rainer, Dierckx, Rudi A. J. O, Elsinga, Philip H.

“…Matrix metalloproteinases (MMPs) are the main proteolytic enzymes involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). A radiolabeled…”
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Poly(ethylene glycol)-Based Stable Isotope Labeling Reagents for the Quantitative Analysis of Low Molecular Weight Metabolites by LC−MS by Abello, Nicolas, Geurink, Paul P, Toorn, Marco van der, Oosterhout, Antoon J. M. van, Lugtenburg, Johan, Marel, Gijs A. van der, Kerstjens, Huib A. M, Postma, Dirkje S, Overkleeft, Hermen S, Bischoff, Rainer

“…Stable isotope labeling (SIL) in combination with liquid chromatography−mass spectrometry is one of the most widely used quantitative analytical methods due to…”
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Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease by Heijink, Irene H, Noordhoek, Jacobien A, Timens, Wim, van Oosterhout, Antoon J M, Postma, Dirkje S

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E-cadherin: gatekeeper of airway mucosa and allergic sensitization by Nawijn, Martijn C, Hackett, Tillie L, Postma, Dirkje S, van Oosterhout, Antoon J.M, Heijink, Irene H

“…The airway epithelium plays a role in immune regulation during environmental challenge, which is intertwined with its barrier function and capacity to limit…”
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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism by Wellaway, Christopher R, Baldwin, Ian R, Bamborough, Paul, Barker, Daniel, Bartholomew, Michelle A, Chung, Chun-wa, Dümpelfeld, Birgit, Evans, John P, Fazakerley, Neal J, Homes, Paul, Keeling, Steven P, Lewell, Xiao Q, McNab, Finlay W, Morley, Joanne, Needham, Deborah, Neu, Margarete, van Oosterhout, Antoon J. M, Pal, Anshu, Reinhard, Friedrich B. M, Rianjongdee, Francesco, Robertson, Craig M, Rowland, Paul, Shah, Rishi R, Sherriff, Emma B, Sloan, Lisa A, Teague, Simon, Thomas, Daniel A, Wellaway, Natalie, Wojno-Picon, Justyna, Woolven, James M, Coe, Diane M

“…The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in…”
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