Search Results - "Van Nyen, G"

Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo by Van Wauwe, J, Van Nyen, G, Coene, M C, Stoppie, P, Cools, W, Goossens, J, Borghgraef, P, Janssen, P A

“…Liarozole is an imidazole-containing compound that inhibits the cytochrome P-450-dependent metabolism of all-trans-retinoic acid (RA). In vitro, liarozole…”
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Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis by Van Wauwe, J, Aerts, F, Cools, M, Deroose, F, Freyne, E, Goossens, J, Hermans, B, Lacrampe, J, Van Genechten, H, Van Gerven, F, Van Nyen, G

“…Interleukin (IL)-5 regulates the growth, differentiation, and activation of eosinophils. When activated, eosinophils release an array of proinflammatory and…”
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Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid by Van Wauwe, J, Coene, M C, Cools, W, Goossens, J, Lauwers, W, Le Jeune, L, Van Hove, C, Van Nyen, G

“…The metabolism of 4-keto-all-trans-retinoic-acid (4-keto-RA), a biologically active oxygenated metabolite of all-trans-retinoic (RA), has been examined. In…”
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R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents by Stoppie, P, Borgers, M, Borghgraef, P, Dillen, L, Goossens, J, Sanz, G, Szel, H, Van Hove, C, Van Nyen, G, Nobels, G, Vanden Bossche, H, Venet, M, Willemsens, G, Van Wauwe, J

“…All-trans-retinoic acid (RA) regulates epithelial differentiation and growth through activation of specific nuclear RA receptors (RARs). Because high-rate…”
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NADPH-dependent formation of 15- and 12-hydroxyeicosatrienoic acid from arachidonic acid by rat epidermal microsomes by Van Wauwe, J, Coene, M C, Van Nyen, G, Cools, W, Goossens, J, Le Jeune, L, Lauwers, W, Janssen, P A

“…Rat epidermal microsomes were incubated with [1-14C]-arachidonic acid for 30 min at 37 degrees C in the absence and presence of NADPH. The arachidonate…”
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Suggested mechanism for the formation of 15-hydroxyeicosatrienoic acid by rat epidermal microsomes by Van Wauwe, J, Coene, M C, Van Nyen, G, Cools, W, Le Jeune, L, Lauwers, W

“…We have previously demonstrated that rat epidermal microsomes NADPH-dependently convert 15(S)-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) into…”
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Inhibition of lymphocyte proliferation by monoclonal antibody directed against the T3 antigen on human T cells by Van Wauwe, J P, Goossens, J, Van Nyen, G

“…Peripheral blood mononuclear cells from 40% of normal donors are mitogenically unresponsive to UCHT1, a monoclonal antibody reactive to the T3 surface molecule…”
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