Search Results - "Van Nostrand, Jeanine L."

Fine-tuning AMPK in physiology and disease using point-mutant mouse models by Ashraf, Naghmana, Van Nostrand, Jeanine L

“…AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that monitors the cellular energy status to adapt it to the…”
Get full text

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models by Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J

“…An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination…”
Get full text

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes by Young, Nathan P, Kamireddy, Anwesh, Van Nostrand, Jeanine L, Eichner, Lillian J, Shokhirev, Maxim Nikolaievich, Dayn, Yelena, Shaw, Reuben J

“…Faithful execution of developmental programs relies on the acquisition of unique cell identities from pluripotent progenitors, a process governed by…”
Get full text

The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes by Bowen, Margot E., McClendon, Jacob, Long, Hannah K., Sorayya, Aryo, Van Nostrand, Jeanine L., Wysocka, Joanna, Attardi, Laura D.

“…Inappropriate activation of the p53 transcription factor contributes to numerous developmental syndromes characterized by distinct constellations of…”
Get full text

Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models by Oravecz-Wilson, Katherine, Lauder, Emma, Taylor, Austin, Maneix, Laure, Van Nostrand, Jeanine L, Sun, Yaping, Li, Lu, Zhao, Dongchang, Liu, Chen, Reddy, Pavan

“…Tissue-intrinsic mechanisms that regulate severity of systemic pathogenic immune-mediated diseases, such as acute graft-versus-host disease (GVHD), remain…”
Get full text

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy by Hung, Chien-Min, Lombardo, Portia S, Malik, Nazma, Brun, Sonja N, Hellberg, Kristina, Van Nostrand, Jeanine L, Garcia, Daniel, Baumgart, Joshua, Diffenderfer, Ken, Asara, John M, Shaw, Reuben J

“…The serine/threonine kinase ULK1 mediates autophagy initiation in response to various cellular stresses, and genetic deletion of ULK1 leads to accumulation of…”
Get full text

Inappropriate p53 activation during development induces features of CHARGE syndrome by Van Nostrand, Jeanine L., Brady, Colleen A., Jung, Heiyoun, Fuentes, Daniel R., Kozak, Margaret M., Johnson, Thomas M., Lin, Chieh-Yu, Lin, Chien-Jung, Swiderski, Donald L., Vogel, Hannes, Bernstein, Jonathan A., Attié-Bitach, Tania, Chang, Ching-Pin, Wysocka, Joanna, Martin, Donna M., Attardi, Laura D.

“…Inappropriate activation of the tumour-suppressor protein p53 during development can promote phenotypes similar to those of CHARGE syndrome, suggesting that…”
Get full text

Siva plays a critical role in mouse embryonic development by Jacobs, Suzanne B. R., Van Nostrand, Jeanine L., Bowen, Margot E., Baker, Julie C., Attardi, Laura D.

“…The Siva protein, named after the Hindu God of Destruction, plays important roles in apoptosis in various contexts, including downstream of death receptor…”
Get full text

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation by Van Nostrand, Jeanine L, Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L, Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N, Dayn, Yelena, Yeo, Gene W, Shaw, Reuben J

“…Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular,…”
Get full text

The p53 family members have distinct roles during mammalian embryonic development by Van Nostrand, Jeanine L, Bowen, Margot E, Vogel, Hannes, Barna, Maria, Attardi, Laura D

“…The p53 tumor suppressor is a member of a multi-protein family, including the p63 and p73 transcription factors. These proteins can bind to the same consensus…”
Get full text

Guilty as CHARGED: p53's expanding role in disease by Van Nostrand, Jeanine L, Attardi, Laura D

“…Unrestrained p53 activity during development, as occurs upon loss of the p53 negative regulators Mdm2 or Mdmx, causes early embryonic lethality. Surprisingly,…”
Get full text

The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development by Van Nostrand, Jeanine L, Brisac, Alice, Mello, Stephano S, Jacobs, Suzanne B R, Luong, Richard, Attardi, Laura D

“…Although p53 transcriptional activation potential is critical for its ability to suppress cancer, the specific target genes involved in tumor suppression…”
Get more information

Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models by Oravecz-Wilson, Katherine, Lauder, Emma, Taylor, Austin, Maneix, Laure, Van Nostrand, Jeanine L, Sun, Yaping, Li, Lu, Zhao, Dongchang, Liu, Chen, Reddy, Pavan

“…Tissue-intrinsic mechanisms that regulate severity of systemic pathogenic immune-mediated diseases, such as acute graft-versus-host disease (CVHD), remain…”
Get full text

The spatiotemporal pattern and intensity of p53 activation during embryogenesis dictates phenotypic diversity in p53-driven developmental syndromes by Bowen, Margot E., McClendon, Jacob, Long, Hannah K., Sorayya, Aryo, Van Nostrand, Jeanine L., Wysocka, Joanna, Attardi, Laura D.

“…Inappropriate activation of the p53 transcription factor contributes to numerous developmental syndromes characterized by distinct constellations of…”
Get full text