Search Results - "Van Moorsel, C J"

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines by VAN MOORSEL, C. J. A, PINEDO, H. M, VEERMAN, G, BERGMAN, A. M, KUIPER, C. M, VERMORKEN, J. B, VAN DER VIJGH, W. J. F, PETERS, G. J

“…2',2'-Difluorodeoxycytidine (gemcitabine, dFdC) and cis-diammine-dichloroplatinum (cisplatin, CDDP) are active agents against ovarian cancer and non-small-cell…”
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Gemcitabine–cisplatin: A schedule finding study by Kroep, J. R., Peters, G. J., van Moorsel, C. J. A., Çatik, A., Vermorken, J. B., Pinedo, H. M., van Groeningen, C. J.

“…Purpose: To evaluate the tolerability of four alternating cisplatin–gemcitabine schedules. A secondary aim was to evaluate the clinical efficacy of this…”
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Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay by Smid, K, Van Moorsel, C J, Noordhuis, P, Voorn, D A, Peters, G J

“…The main mechanism of action of the anticancer drug gemcitabine is assumed to be incorporation of its triphosphate (dFdCTP) into DNA, resulting in inhibition…”
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Gemcitabine and Paclitaxel: Pharmacokinetic and Pharmacodynamic Interactions in Patients With Non–Small-Cell Lung Cancer by KROEP, J. R, GIACCONE, G, PETERS, G. J, VOORN, D. A, SMIT, E. F, BEIJNEN, J. H, ROSING, H, VAN MOORSEL, C. J. A, VAN GROENINGEN, C. J, POSTMUS, P. E, PINEDO, H. M

“…To assess possible pharmacokinetic and pharmacodynamic interactions between gemcitabine and paclitaxel in a phase I/II study in non-small-cell lung cancer…”
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Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors by van Moorsel, C.J.A., Kroep, J.R., Pinedo, H.M., Veerman, G., Voorn, D.A., Postmus, P.E., Vermorken, J. B., van Groeningen, C.J., van der Vijgh, W.J.F., Peters, G.J.

“…Purpose: To determine possible schedule dependent pharmacokinetic and pharmacodynamic interactions between gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and…”
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Scheduling of gemcitabine and cisplatin in Lewis Lung tumour bearing mice by van Moorsel, C.J.A, Pinedo, H.M, Veerman, G, Vermorken, J.B, Postmus, P.E, Peters, G.J

“…We used the gemcitabine (dFdC) and cisplatin (cis-diamine dichloroplatinum CDDP) resistant murine NSCLC tumour Lewis Lung (LL) in C57/Bl6 mice to optimise…”
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Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines by Van Moorsel, C J A, Smid, K, Voorn, D A, Bergman, A M, Pinedo, H M, Peters, G J

“…Gemcitabine (dFdC) and cisplatin (CDDP) act synergistically by an increase in platinum-DNA adduct formation. Since ribonucleotide (NTP) and deoxyribonucleotide…”
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Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs by Bergman, A.M., Giaccone, G., van Moorsel, C.J.A., Mauritz, R., Noordhuis, P., Pinedo, H.M., Peters, G.J.

“…Gemcitabine (2′-2′-difluorodeoxycytidine; dFdC) is a deoxycytidine analogue which is effective against solid tumours, including lung cancer and ovarian cancer…”
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Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours by van Moorsel, C.J.A, Pinedo, H.M, Smid, K, Comijn, E.M, Voorn, D.A, Veerman, G, Lakerveld, B, Van der Vijgh, W.J.F, Giaccone, G, Postmus, P.E, Peters, G.J

“…The combination of 2′,2′-difluorodeoxycytidine (gemcitabine, dFdC) and cis-diammine-dichloroplatinum(II) (cisplatin, CDDP) is increasingly applied in clinical…”
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Combination chemotherapy studies with gemcitabine by van Moorsel, C J, Veerman, G, Bergman, A M, Guechev, A, Vermorken, J B, Postmus, P E, Peters, G J

“…Gemcitabine (2',2'-difluorodeoxycytidine) is an antineoplastic agent with clinical activity against ovarian carcinoma, small cell and non-small cell lung…”
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Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines by van Moorsel, Catharina J.A, Pinedo, Herbert M, Veerman, Gijsbert, Guechev, Assen, Smid, Kees, Loves, Willem J.P, Vermorken, Jan B, Postmus, Pieter E, Peters, Godefridus J

“…Gemcitabine (2′,2′-difluorodeoxycytidine, dFdC) and etoposide (4′-demethylepipodo-phyllotoxin-9-4,6- O-ethylidene-β- d-glucopyranoside, VP-16) are…”
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Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC) by Kroep, J R, van Moorsel, C J, Veerman, G, Voorn, D A, Schultz, R M, Worzalla, J F, Tanzer, L R, Merriman, R L, Pinedo, H M, Peters, G J

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Mechanisms of synergism between gemcitabine and cisplatin by van Moorsel, C J, Veerman, G, Vermorken, J B, Voorn, D A, Kroep, J R, Bergman, A M, Pinedo, H M, Peters, G J

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TaqI and RsaI polymorphisms in the H19 gene (D11S813E) by Redeker, E, Van Moorsel, C J, Feinberg, A, Mannens, M

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Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines by van Moorsel, C J, Veerman, G, Ruiz van Haperen, V W, Bergman, A M, Jensen, P B, Sehested, M, Peters, G J

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An integrated physical map of 210 markers assigned to the short arm of human chromosome 11 by Redeker, E, Hoovers, J M, Alders, M, van Moorsel, C J, Ivens, A C, Gregory, S, Kalikin, L, Bliek, J, de Galan, L, van den Bogaard, R

“…Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15,…”
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Vitamin A and β-carotene influence the level of benzo[ a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture by Wolterbeek, Andreas P.M., Roggeband, Robert, van Moorsel, Catherina J.A., Baan, Robert A., Koeman, Jan H., Feron, Victor J., Rutten, Alphons A.J.J.L.

“…Although most studies concerning the effect of vitamin A and β-carotene on chemical carcinogenesis are focused on tumour promotion and progression, these…”
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Basis for effective combination cancer chemotherapy with antimetabolites by Peters, G.J., van der Wilt, C.L., van Moorsel, C.J.A., Kroep, J.R., Bergman, A.M., Ackland, S.P.

“…Most current chemotherapy regimens for cancer consist of empirically designed combinations, based on efficacy and lack of overlapping toxicity. In the…”
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Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines by van Moorsel, Catharina J.A, Bergman, Andries M, Veerman, Gijsbert, Voorn, Daphne A, Ruiz van Haperen, Veronique W.T, Kroep, Judith R, Pinedo, Herbert M, Peters, Godefridus J

“…To gain a more detailed insight into the metabolism of 2′,2′-difluoro-2′-deoxycytidine (dFdC, gemcitabine, Gemzar) and its effect on normal ribonucleotide…”
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Preclinical combination therapy with gemcitabine and mechanisms of resistance by Peters, G J, Ruiz van Haperen, V W, Bergman, A M, Veerman, G, Smitskamp-Wilms, E, van Moorsel, C J, Kuiper, C M, Braakhuis, B J

“…Cisplatin and gemcitabine both have activity in solid tumors, such as non-small cell lung, ovarian, and head and neck cancers. These drugs have the desired…”
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