Search Results - "Van Ly, David"
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Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress
Published in Nature cell biology (01-12-2020)“…Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally…”
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Telomere Loop Dynamics in Chromosome End Protection
Published in Molecular cell (16-08-2018)“…Telomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation…”
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3
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
Published in Nature (London) (01-11-2019)“…The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the…”
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Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma
Published in Respirology (Carlton, Vic.) (01-01-2016)“…Background and objective Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in the airways and the mechanisms that…”
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5
Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells
Published in PloS one (15-02-2013)“…Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to β2…”
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6
Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase
Published in Ocular oncology and pathology (01-12-2020)“…Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the…”
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Effects of β_2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
Published in Journal of Allergy (01-12-2011)“…Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia. The cellular mechanism underlying this…”
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8
TRF2-independent chromosome end protection during pluripotency
Published in Nature (London) (07-01-2021)“…Mammalian telomeres protect chromosome ends from aberrant DNA repair 1 . TRF2, a component of the telomere-specific shelterin protein complex, facilitates end…”
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9
Differential neutrophil activation in viral infections: Enhanced TLR ‐7/8‐mediated CXCL 8 release in asthma
Published in Respirology (Carlton, Vic.) (01-01-2016)“…Abstract Background and objective Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in the airways and the…”
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10
Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle
Published in Respiratory research (15-11-2013)“…Virus-induced exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a significant health burden and occur even in those receiving the best current…”
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11
Characterising the Mechanism of Airway Smooth Muscle [beta].sub.2 Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells
Published in PloS one (15-02-2013)“…Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to…”
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12
Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12
Published in Oncoimmunology (03-03-2016)“…Activated antigen-presenting cells (APC) deliver the three signals cytotoxic T cells require to differentiate into effector cells that destroy the tumor. These…”
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13
Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts
Published in American journal of physiology. Lung cellular and molecular physiology (01-08-2012)“…Eicosanoids are lipid-signaling mediators released by many cells in response to various stimuli. Increasing evidence suggests that eicosanoids such as…”
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14
Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
Published in Journal of allergy (2011)“…Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia. The cellular mechanism underlying this…”
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15
Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
Published in Journal of allergy (2011)“…Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia. The cellular mechanism underlying this…”
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16
Do we really need to keep redesigning β2-agonists for the management of asthma?
Published in Current drug delivery (2015)“…There is an enormous drive to refine therapeutic designs and delivery systems, but in this review we ask if this is always the right direction? We choose to…”
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17
Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase
Published in Ocular oncology and pathology (01-12-2020)Get full text
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