Search Results - "Van Loo, J A"

Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing by Fafián-Labora, Juan, Morente-López, Miriam, Sánchez-Dopico, María José, Arntz, Onno J, van de Loo, Fons A J, De Toro, Javier, Arufe, María C

“…This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they…”
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Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants by Vago, Juliana P, Valdrighi, Natália, Blaney-Davidson, Esmeralda N, Hornikx, Daniel L A H, Neefjes, Margot, Barba-Sarasua, María E, Thielen, Nathalie G M, van den Bosch, Martijn H J, van der Kraan, Peter M, Koenders, Marije I, Amaral, Flávio A, van de Loo, Fons A J

“…Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage degeneration, synovitis, and bone sclerosis, resulting in…”
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Innate Immunity and Sex: Distinct Inflammatory Profiles Associated with Murine Pain in Acute Synovitis by Valdrighi, Natália, Blom, Arjen B, Vago, Juliana P, van Beuningen, Henk M, Vitters, Elly L, Helsen, Monique M, Walgreen, Birgitte, Arntz, Onno J, Koenders, Marije I, van der Kraan, Peter M, Blaney Davidson, Esmeralda N, van de Loo, Fons A J

“…Joint pain severity in arthritic diseases differs between sexes and is often more pronounced in women. This disparity is thought to stem from biological…”
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Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells by Mato-Basalo, Rocío, Morente-López, Miriam, Arntz, Onno J, van de Loo, Fons A J, Fafián-Labora, Juan, Arufe, María C

“…Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these…”
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A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis by Oude Ophuis, Ralph J A, Wijers, Mietske, Bennink, Miranda B, van de Loo, Fons A J, Fransen, Jack A M, Wieringa, Bé, Wansink, Derick G

“…Studies on the myotonic dystrophy protein kinase (DMPK) gene and gene products have thus far mainly concentrated on the fate of length mutation in the (CTG)n…”
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Polyethylene glycol precipitation is an efficient method to obtain extracellular vesicle-depleted fetal bovine serum by Wang, Peng, Arntz, Onno J, Husch, Johanna F A, Kraan P M, Van der, Beucken, Jeroen J J P van den, van de Loo, Fons A J

“…Mesenchymal stromal/stem cell derived-extracellular vesicles (MSC-EVs) have gained interest as drug delivery nanoparticles, having immunoregulatory and…”
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Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis by van den Brand, Ben T, Vermeij, Eline A, Waterborg, Claire E J, Arntz, Onno J, Kracht, Michael, Bennink, Miranda B, van den Berg, Wim B, van de Loo, Fons A J

“…Antigen presenting cells (APCs) play an important role in arthritis and APC specific gene therapeutic targeting will enable intracellular modulation of cell…”
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The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment by Kumrungsee, Thanutchaporn, Kariya, Taishi, Hashimoto, Kotaro, Koyano, Takayuki, Yazawa, Nao, Hashimoto, Takao, Sanada, Yohei, Matsuyama, Makoto, Sotomaru, Yusuke, Sakurai, Hiroaki, van de Loo, Fons A. J., Yanaka, Noriyuki

“…Tubulointerstitial fibrosis is a progressive process affecting the kidneys, causing renal failure that can be life-threatening. Thus, renal fibrosis has become…”
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Driving performance of long-term users of sedating antidepressants and benzodiazepines by Westerhuis, F., Van Dijken, J. H., Veldstra, J. L., Brookhuis, K. A., Verster, J. C., Van de Loo, A. J. A. E., Vinckenbosch, F. R. J., Vermeeren, A., Van der Sluiszen, N. N. J. J. M., Ramaekers, J. G., De Waard, D.

“…Using benzodiazepines and certain antidepressants is associated with an increased risk of motor vehicle crashes due to impaired driving skills. Hence, several…”
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Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis by Waterborg, Claire E J, Koenders, Marije I, van Lent, Peter L E M, van der Kraan, Peter M, van de Loo, Fons A J

“…Rheumatoid arthritis is an auto-immune disease of the synovial joints, hallmarked by chronic inflammation and subsequent progressive tissue destruction. TYRO3,…”
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Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis by Broeren, Mathijs G A, de Vries, Marieke, Bennink, Miranda B, Arntz, Onno J, Blom, Arjen B, Koenders, Marije I, van Lent, Peter L E M, van der Kraan, Peter M, van den Berg, Wim B, van de Loo, Fons A J

“…Disease-inducible promoters for the treatment of rheumatoid arthritis (RA) have the potential to provide regulated expression of therapeutic proteins in…”
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Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium by Broeren, Mathijs G A, de Vries, Marieke, Bennink, Miranda B, van Lent, Peter L E M, van der Kraan, Peter M, Koenders, Marije I, Thurlings, Rogier M, van de Loo, Fons A J

“…Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and is the most common form of arthritis worldwide. One third of OA patients have…”
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The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study by van de Loo, Aurora J. A. E., Bervoets, Adriana C., Mooren, Loes, Bouwmeester, Noor H., Garssen, Johan, Zuiker, Rob, van Amerongen, Guido, van Gerven, Joop, Singh, Jaskaran, der Ark, Peter Van, Fedgchin, Maggie, Morrison, Randall, Wajs, Ewa, Verster, Joris C.

“…Rationale The purpose of this study is to evaluate the single dose effect of intranasal esketamine (84 mg) compared to placebo on on-road driving performance…”
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Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice by Rogier, Rebecca, Ederveen, Thomas H A, Wopereis, Harm, Hartog, Anita, Boekhorst, Jos, van Hijum, Sacha A F T, Knol, Jan, Garssen, Johan, Walgreen, Birgitte, Helsen, Monique M, van der Kraan, Peter M, van Lent, Peter L E M, van de Loo, Fons A J, Abdollahi-Roodsaz, Shahla, Koenders, Marije I

“…[This corrects the article DOI: 10.1371/journal.pone.0219366.]…”
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Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis by van de Loo, Fons A., Amaral, Flávio A., van Lent, Peter L. E. M., Koenders, Marije I., Thurlings, Rogier M., Waterborg, Claire E. J., Vago, Juliana Priscila, Vullings, Julia, van der Kraan, Peter M.

“…Objective. To investigate the role of TAM receptors in rheumatoid arthritis (RA) by determining synovial tissue TAM receptor expression, synovial fluid levels…”
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The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis by Vermeij, Eline A, Koenders, Marije I, Bennink, Miranda B, Crowe, Lindsey A, Maurizi, Lionel, Vallée, Jean-Paul, Hofmann, Heinrich, van den Berg, Wim B, van Lent, Peter L E M, van de Loo, Fons A J

“…Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an…”
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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis by Geven, Edwin J W, van den Bosch, Martijn H J, Di Ceglie, Irene, Ascone, Giuliana, Abdollahi-Roodsaz, Shahla, Sloetjes, Annet W, Hermann, Sven, Schäfers, Michael, van de Loo, Fons A J, van der Kraan, Peter M, Koenders, Marije I, Foell, Dirk, Roth, Johannes, Vogl, Thomas, van Lent, Peter L E M

“…Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a…”
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IL-32, a Proinflammatory Cytokine in Rheumatoid Arthritis by Joosten, Leo A. B., Netea, Mihai G., Kim, Soo-Hyun, Yoon, Do-Young, Oppers-Walgreen, Birgitte, Radstake, Timothy R. D., Barrera, Pilar, van de Loo, Fons A. J., Dinarello, Charles A., van den Berg, Wim B.

“…IL-32 is a recently discovered cytokine that induces TNFα, IL-1β, IL-6, and chemokines. We investigated whether IL-32 is expressed in the synovia of patients…”
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Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes by Thielen, Nathalie G M, Neefjes, Margot, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Koenders, Marije I, van Lent, Peter L E M, van de Loo, Fons A J, Blaney Davidson, Esmeralda N, van Caam, Arjan P M, van der Kraan, Peter M

“…During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like)…”
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Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis by Di Ceglie, Irene, Ascone, Giuliana, Cremers, Niels A J, Sloetjes, Annet W, Walgreen, Birgitte, Vogl, Thomas, Roth, Johannes, Verbeek, J Sjef, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ…”
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