Search Results - "Van Lier, Rene"

Tissue-resident memory T cells at the center of immunity to solid tumors by Amsen, Derk, van Gisbergen, Klaas P. J. M., Hombrink, Pleun, van Lier, Rene A. W.

“…Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (T RM cells) are a recently…”
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Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes by Mackay, Laura K., Minnich, Martina, Kragten, Natasja A. M., Liao, Yang, Nota, Benjamin, Seillet, Cyril, Zaid, Ali, Man, Kevin, Preston, Simon, Freestone, David, Braun, Asolina, Wynne-Jones, Erica, Behr, Felix M., Stark, Regina, Pellicci, Daniel G., Godfrey, Dale I., Belz, Gabrielle T., Pellegrini, Marc, Gebhardt, Thomas, Busslinger, Meinrad, Shi, Wei, Carbone, Francis R., van Lier, René A. W., Kallies, Axel, van Gisbergen, Klaas P. J. M.

“…Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce…”
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Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses by Behr, Felix M., Parga-Vidal, Loreto, Kragten, Natasja A. M., van Dam, Teunis J. P., Wesselink, Thomas H., Sheridan, Brian S., Arens, Ramon, van Lier, Rene A. W., Stark, Regina, van Gisbergen, Klaas P. J. M.

“…Tissue-resident memory CD8 + T cells (T RM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue…”
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Phenotype and function of human T lymphocyte subsets: Consensus and issues by Appay, Victor, van Lier, Rene A.W, Sallusto, Federica, Roederer, Mario

“…In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in…”
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Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity by Cuadrado, Eloy, van den Biggelaar, Maartje, de Kivit, Sander, Chen, Yi-yen, Slot, Manon, Doubal, Ihsane, Meijer, Alexander, van Lier, Rene A.W., Borst, Jannie, Amsen, Derk

“…To obtain a molecular definition of regulatory T (Treg) cell identity, we performed proteomics and transcriptomics on various populations of human regulatory…”
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Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis by Matlung, Hanke L., Babes, Liane, Zhao, Xi Wen, van Houdt, Michel, Treffers, Louise W., van Rees, Dieke J., Franke, Katka, Schornagel, Karin, Verkuijlen, Paul, Janssen, Hans, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Leusen, Jeanette H.W., Boelens, Jaap J., Kuhnle, Ingrid, van der Werff Ten Bosch, Jutte, Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Matozaki, Takashi, Suzuki, Eiji, Menke-van der Houven van Oordt, Catharina Willemien, van Bruggen, Robin, Roos, Dirk, van Lier, Rene A.W., Kuijpers, Taco W., Kubes, Paul, van den Berg, Timo K.

“…Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be…”
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CD20 deficiency in humans results in impaired T cell-independent antibody responses by Kuijpers, Taco W, Bende, Richard J, Baars, Paul A, Grummels, Annette, Derks, Ingrid A M, Dolman, Koert M, Beaumont, Tim, Tedder, Thomas F, van Noesel, Carel J M, Eldering, Eric, van Lier, René A W

“…CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and…”
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CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets by Vossen, Mireille T. M, Matmati, Mourad, Hertoghs, Kirsten M. L, Baars, Paul A, Gent, Mi-Ran, Leclercq, Georges, Hamann, Jorg, Kuijpers, Taco W, van Lier, Rene A. W

“…The absence of the TNF-receptor family member CD27 marks the stable acquisition of cytolytic effector functions by both CD4(+) and CD8(+) T cells. We found…”
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Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8 + T Cells in the Lungs by Behr, Felix M, Kragten, Natasja A M, Wesselink, Thomas H, Nota, Benjamin, van Lier, Rene A W, Amsen, Derk, Stark, Regina, Hombrink, Pleun, van Gisbergen, Klaas P J M

“…Tissue-resident memory CD8 T (T ) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection…”
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How to Reliably Define Human CD8 + T-Cell Subsets: Markers Playing Tricks by van Aalderen, Michiel C, van Lier, Rene A W, Hombrink, Pleun

“…In recent years, our understanding about the functional complexity of CD8 T-cell populations has increased tremendously. The immunology field is now facing…”
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Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55 by Karpus, Olga N, Veninga, Henrike, Hoek, Robert M, Flierman, Dennis, van Buul, Jaap D, Vandenakker, Corianne C, vanBavel, Ed, Medof, M Edward, van Lier, René A W, Reedquist, Kris A, Hamann, Jörg

“…Adhesion G protein-coupled receptors (aGPCRs) are two-subunit molecules, consisting of an adhesive extracellular α subunit that couples noncovalently to a…”
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Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool by van de Berg, Pablo J. E. J, Griffiths, Stephen J, Yong, Si-La, Macaulay, Richard, Bemelman, Frederike J, Jackson, Sarah, Henson, Sian M, ten Berge, Ineke J. M, Akbar, Arne N, van Lier, Rene A. W

“…Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations…”
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The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8 + T Cell Responses of Low Antigen Affinity to Protect against Viral Variants by van Gisbergen, Klaas P.J.M., Klarenbeek, Paul L., Kragten, Natasja A.M., Unger, Peter-Paul A., Nieuwenhuis, Marieke B.B., Wensveen, Felix M., ten Brinke, Anja, Tak, Paul P., Eldering, Eric, Nolte, Martijn A., van Lier, Rene A.W.

“…CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8 + T cells. Here, we show that CD27-driven…”
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Human NK cells can control CMV infection in the absence of T cells by Kuijpers, Taco W., Baars, Paul A., Dantin, Carole, van den Burg, Mirjam, van Lier, Rene A.W., Roosnek, Eddy

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Cytomegalovirus-Induced Effector T Cells Cause Endothelial Cell Damage by van de Berg, Pablo J E J, Yong, Si-La, Remmerswaal, Ester B M, van Lier, René A W, ten Berge, Ineke J M

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Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment by Kragten, Natasja AM, Taggenbrock, Renske LRE, Parga Vidal, Loreto, van Lier, Rene AW, Stark, Regina, van Gisbergen, Klaas PJM

“…iNKT cells are CD1d‐restricted T cells that play a pro‐inflammatory or regulatory role in infectious and autoimmune diseases. Thymic precursors of iNKT cells…”
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Tumor immunity requires border patrol to fight the enemy within by Amsen, Derk, Hombrink, Pleun, van Lier, Rene A W

“…The infiltration of solid tumors by CD8 + T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from…”
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Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations by Kuijpers, Taco W., Ijspeert, Hanna, van Leeuwen, Ester M.M., Jansen, Machiel H., Hazenberg, Mette D., Weijer, Kees C., van Lier, Rene A.W., van der Burg, Mirjam

“…A girl presented during childhood with a single course of extensive chickenpox and moderate albeit recurrent pneumonia in the presence of idiopathic CD4+ T…”
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Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy by de Niet, Annikki, Stelma, Femke, Jansen, Louis, Sinnige, Marjan J, Remmerswaal, Ester B.M, Takkenberg, R. Bart, Kootstra, Neeltje A, Reesink, Hendrik W, van Lier, Rene A.W, van Leeuwen, Ester M.M

“…Graphical abstract…”
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B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function by Serriari, Nacer-Eddine, Gondois-Rey, Françoise, Guillaume, Yves, Remmerswaal, Ester B M, Pastor, Sonia, Messal, Nassima, Truneh, Alemseged, Hirsch, Ivan, van Lier, René A W, Olive, Daniel

“…B and T lymphocyte attenuator (BTLA), like its relative programmed cell death-1 (PD-1), is a receptor that negatively regulates murine T cell activation…”
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