Search Results - "Van Lent, Peter L. E. M."

Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis by ter Huurne, Menno, Schelbergen, Rik, Blattes, Roxane, Blom, Arjen, de Munter, Wouter, Grevers, Lilyanne C., Jeanson, Jannik, Noël, Danièle, Casteilla, Louis, Jorgensen, Christian, van den Berg, Wim, van Lent, Peter L. E. M.

“…Objective In experimental collagenase‐induced osteoarthritis (OA) in the mouse, synovial lining macrophages are crucial in mediating joint destruction. It was…”
Get full text

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane by Broeren, Mathijs G A, de Vries, Marieke, Bennink, Miranda B, Arntz, Onno J, van Lent, Peter L E M, van der Kraan, Peter M, van den Berg, Wim B, van den Hoogen, Frank H J, Koenders, Marije I, van de Loo, Fons A J

“…Gene therapy has the potential to provide long-term production of therapeutic proteins in the joints of osteoarthritis (OA) patients. The objective of this…”
Get full text

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis by Cremers, Niels A. J., van den Bosch, Martijn H. J., van Dalen, Stephanie, Di Ceglie, Irene, Ascone, Giuliana, van de Loo, Fons, Koenders, Marije, van der Kraan, Peter, Sloetjes, Annet, Vogl, Thomas, Roth, Johannes, Geven, Edwin J. W., Blom, Arjen B., van Lent, Peter L. E. M.

“…Background Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets…”
Get full text

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis by Waterborg, Claire E J, Koenders, Marije I, van Lent, Peter L E M, van der Kraan, Peter M, van de Loo, Fons A J

“…Rheumatoid arthritis is an auto-immune disease of the synovial joints, hallmarked by chronic inflammation and subsequent progressive tissue destruction. TYRO3,…”
Get full text

S100A8/A9 is not essential for the development of inflammation and joint pathology in interleukin-1 receptor antagonist knockout mice by Di Ceglie, Irene, van Lent, Peter L E M, Geven, Edwin J W, Koenders, Marije I, Blom, Arjen B, Vogl, Thomas, Roth, Johannes, van den Bosch, Martijn H J

“…Excessive osteoclast activity, which is strongly stimulated by pro-inflammatory mediators, results in bone and cartilage degeneration as central features of…”
Get full text

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium by Broeren, Mathijs G A, de Vries, Marieke, Bennink, Miranda B, van Lent, Peter L E M, van der Kraan, Peter M, Koenders, Marije I, Thurlings, Rogier M, van de Loo, Fons A J

“…Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and is the most common form of arthritis worldwide. One third of OA patients have…”
Get full text

S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll‐like receptor 4: Implications for bone destruction in murine antigen‐induced arthritis by Grevers, Lilyanne C., de Vries, Teun J., Vogl, Thomas, Abdollahi‐Roodsaz, Shahla, Sloetjes, Annet W., Leenen, Pieter J. M., Roth, Johannes, Everts, Vincent, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective Rheumatoid arthritis, which is associated with elevated levels of S100A8 and S100A9, is characterized by severe bone erosions caused by enhanced…”
Get full text

Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice by Rogier, Rebecca, Ederveen, Thomas H A, Wopereis, Harm, Hartog, Anita, Boekhorst, Jos, van Hijum, Sacha A F T, Knol, Jan, Garssen, Johan, Walgreen, Birgitte, Helsen, Monique M, van der Kraan, Peter M, van Lent, Peter L E M, van de Loo, Fons A J, Abdollahi-Roodsaz, Shahla, Koenders, Marije I

“…[This corrects the article DOI: 10.1371/journal.pone.0219366.]…”
Get full text

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis by Vermeij, Eline A, Koenders, Marije I, Bennink, Miranda B, Crowe, Lindsey A, Maurizi, Lionel, Vallée, Jean-Paul, Hofmann, Heinrich, van den Berg, Wim B, van Lent, Peter L E M, van de Loo, Fons A J

“…Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an…”
Get full text

S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis by Geven, Edwin J W, van den Bosch, Martijn H J, Di Ceglie, Irene, Ascone, Giuliana, Abdollahi-Roodsaz, Shahla, Sloetjes, Annet W, Hermann, Sven, Schäfers, Michael, van de Loo, Fons A J, van der Kraan, Peter M, Koenders, Marije I, Foell, Dirk, Roth, Johannes, Vogl, Thomas, van Lent, Peter L E M

“…Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a…”
Get full text

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis by Di Ceglie, Irene, Ascone, Giuliana, Cremers, Niels A J, Sloetjes, Annet W, Walgreen, Birgitte, Vogl, Thomas, Roth, Johannes, Verbeek, J Sjef, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ…”
Get full text

Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis by van de Loo, Fons A., Amaral, Flávio A., van Lent, Peter L. E. M., Koenders, Marije I., Thurlings, Rogier M., Waterborg, Claire E. J., Vago, Juliana Priscila, Vullings, Julia, van der Kraan, Peter M.

“…Objective. To investigate the role of TAM receptors in rheumatoid arthritis (RA) by determining synovial tissue TAM receptor expression, synovial fluid levels…”
Get full text

Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes by Thielen, Nathalie G M, Neefjes, Margot, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Koenders, Marije I, van Lent, Peter L E M, van de Loo, Fons A J, Blaney Davidson, Esmeralda N, van Caam, Arjan P M, van der Kraan, Peter M

“…During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like)…”
Get full text

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β by Pieters, Bartijn C H, Arntz, Onno J, Bennink, Miranda B, Broeren, Mathijs G A, van Caam, Arjan P M, Koenders, Marije I, van Lent, Peter L E M, van den Berg, Wim B, de Vries, Marieke, van der Kraan, Peter M, van de Loo, Fons A J

“…Extracellular vesicles, including exosomes, have been identified in all biological fluids and rediscovered as an important part of the intercellular…”
Get full text

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis by van Lent, Peter L. E. M., Blom, Arjen B., Schelbergen, Rik F. P., Slöetjes, Annet, Lafeber, Floris P. J. G., Lems, Willem F., Cats, Hans, Vogl, Thomas, Roth, Johannes, van den Berg, Wim B.

“…Objective To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)…”
Get full text

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis? by de Munter, Wouter, van der Kraan, Peter M, van den Berg, Wim B, van Lent, Peter L E M

“…There is increasing evidence that low-density lipoprotein (LDL) cholesterol plays a role in the pathology of OA. Specifically, oxidized LDL (oxLDL), which has…”
Get full text

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4 by Schelbergen, Rik F. P., Blom, Arjen B., van den Bosch, Martijn H. J., Slöetjes, Annet, Abdollahi-Roodsaz, Shahla, Schreurs, B. Wim, Mort, John S., Vogl, Thomas, Roth, Johannes, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective S100A8 and S100A9 are two Ca2+ binding proteins classified as damage‐associated molecular patterns or alarmins that are found in high amounts in the…”
Get full text

Long‐Term Detection of Human Adipose‐Derived Mesenchymal Stem Cells After Intraarticular Injection in SCID Mice by Toupet, Karine, Maumus, Marie, Peyrafitte, Julie‐Anne, Bourin, Philippe, Lent, Peter L. E. M., Ferreira, Rosanna, Orsetti, Béatrice, Pirot, Nelly, Casteilla, Louis, Jorgensen, Christian, Noël, Danièle

“…Objective Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy for several disorders, among them the osteoarticular diseases. For such…”
Get full text

Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc by van den Akker, Guus G. H., Koenders, Marije I., van de Loo, Fons A. J., van Lent, Peter L. E. M., Blaney Davidson, Esmeralda, van der Kraan, Peter M.

“…Background Cells in the intervertebral disc have unique phenotypes and marker genes that separate the nucleus pulposus (NP), annulus fibrosus (AF) and…”
Get full text

An optimized method for plasma extracellular vesicles isolation to exclude the copresence of biological drugs and plasma proteins which impairs their biological characterization by Arntz, Onno J, Pieters, Bartijn C.H, van Lent, Peter L.E.M, Koenders, Marije I, van der Kraan, Peter M, van de Loo, Fons A.J

“…Extracellular vesicles (EVs) are cell membrane-derived phospholipid bilayer nanostructures that contain bioactive proteins, enzymes, lipids and polymers of…”
Get full text