Search Results - "Van Lent, Jonas"

Harmony in chaos: understanding cancer through the lenses of developmental biology by Van Lent, Jonas, Baggiolini, Arianna

“…When we think about cancer, the link to development might not immediately spring to mind. Yet, many foundational concepts in cancer biology trace their roots…”
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A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins by Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin

“…HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause…”
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Advances and challenges in modeling inherited peripheral neuropathies using iPSCs by Van Lent, Jonas, Prior, Robert, Pérez Siles, Gonzalo, Cutrupi, Anthony N., Kennerson, Marina L., Vangansewinkel, Tim, Wolfs, Esther, Mukherjee-Clavin, Bipasha, Nevin, Zachary, Judge, Luke, Conklin, Bruce, Tyynismaa, Henna, Clark, Alex J., Bennett, David L., Van Den Bosch, Ludo, Saporta, Mario, Timmerman, Vincent

“…Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations in various genes with fundamental roles in the development and…”
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Defects in Axonal Transport in Inherited Neuropathies by Beijer, Danique, Sisto, Angela, Van Lent, Jonas, Baets, Jonathan, Timmerman, Vincent

“…Axonal transport is a highly complex process essential for sustaining proper neuronal functioning. Disturbances can result in an altered neuronal homeostasis,…”
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Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A by Van Lent, Jonas, Vendredy, Leen, Adriaenssens, Elias, Da Silva Authier, Tatiana, Asselbergh, Bob, Kaji, Marcus, Weckhuysen, Sarah, Van Den Bosch, Ludo, Baets, Jonathan, Timmerman, Vincent

“…Abstract Charcot–Marie–Tooth disease is the most common inherited disorder of the PNS. CMT1A accounts for 40–50% of all cases and is caused by a duplication of…”
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Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction by Van Lent, Jonas, Verstraelen, Peter, Asselbergh, Bob, Adriaenssens, Elias, Mateiu, Ligia, Verbist, Christophe, De Winter, Vicky, Eggermont, Kristel, Van Den Bosch, Ludo, De Vos, Winnok H, Timmerman, Vincent

“…Axonal Charcot-Marie-Tooth neuropathies (CMT type 2) are caused by inherited mutations in various genes functioning in different pathways. The types of genes…”
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A reference human induced pluripotent stem cell line for collaborative studies by Pantazis, CB, Yang, A, Lara, E, McDonough, JA, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D

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Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies by Lischka, Annette, Eggermann, Katja, Record, Christopher J, Dohrn, Maike F, Laššuthová, Petra, Kraft, Florian, Begemann, Matthias, Dey, Daniela, Eggermann, Thomas, Beijer, Danique, Šoukalová, Jana, Laura, Matilde, Rossor, Alexander M, Mazanec, Radim, Van Lent, Jonas, Tomaselli, Pedro J, Ungelenk, Martin, Debus, Karlien Y, Feely, Shawna M E, Gläser, Dieter, Jagadeesh, Sujatha, Martin, Madelena, Govindaraj, Geeta M, Singhi, Pratibha, Baineni, Revanth, Biswal, Niranjan, Ibarra-Ramírez, Marisol, Bonduelle, Maryse, Gess, Burkhard, Romero Sánchez, Juan, Suthar, Renu, Udani, Vrajesh, Nalini, Atchayaram, Unnikrishnan, Gopikrishnan, Marques, Junior, Wilson, Mercier, Sandra, Procaccio, Vincent, Bris, Céline, Suresh, Beena, Reddy, Vaishnavi, Skorupinska, Mariola, Bonello-Palot, Nathalie, Mochel, Fanny, Dahl, Georg, Sasidharan, Karthika, Devassikutty, Fiji M, Nampoothiri, Sheela, Rodovalho Doriqui, Maria J, Müller-Felber, Wolfgang, Vill, Katharina, Haack, Tobias B, Dufke, Andreas, Abele, Michael, Stucka, Rolf, Siddiqi, Saima, Ullah, Noor, Spranger, Stephanie, Chiabrando, Deborah, Bolgül, Behiye S, Parman, Yesim, Seeman, Pavel, Lampert, Angelika, Schulz, Jörg B, Wood, John N, Cox, James J, Auer-Grumbach, Michaela, Timmerman, Vincent, de Winter, Jonathan, Themistocleous, Andreas C, Shy, Michael, Bennett, David L, Baets, Jonathan, Hübner, Christian A, Leipold, Enrico, Züchner, Stephan, Elbracht, Miriam, Çakar, Arman, Senderek, Jan, Hornemann, Thorsten, Woods, C Geoffrey, Reilly, Mary M, Kurth, Ingo

“…Congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders…”
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Genetic pain loss disorders by Lischka, Annette, Lassuthova, Petra, Çakar, Arman, Record, Christopher J., Van Lent, Jonas, Baets, Jonathan, Dohrn, Maike F., Senderek, Jan, Lampert, Angelika, Bennett, David L., Wood, John N., Timmerman, Vincent, Hornemann, Thorsten, Auer-Grumbach, Michaela, Parman, Yesim, Hübner, Christian A., Elbracht, Miriam, Eggermann, Katja, Geoffrey Woods, C., Cox, James J., Reilly, Mary M., Kurth, Ingo

“…Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory neuropathies and, if autonomic nerves are involved, hereditary sensory…”
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