Search Results - "Van Kirk, Edward A."

Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs by Sun, Qihang, Sun, Xuanrong, Ma, Xinpeng, Zhou, Zhuxian, Jin, Erlei, Zhang, Bo, Shen, Youqing, Van Kirk, Edward A., Murdoch, William J., Lott, Joseph R., Lodge, Timothy P., Radosz, Maciej, Zhao, Yuliang

“…A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade…”
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Virion-Mimicking Nanocapsules from pH-Controlled Hierarchical Self-Assembly for Gene Delivery by Xu, Peisheng, Li, Shi-Yan, Li, Qun, Van Kirk, Edward A, Ren, Jun, Murdoch, William J, Zhang, Zhaojie, Radosz, Maciej, Shen, Youqing

“…A new concept for fabricating nanocarriers carrying free DNA for gene delivery to overcome the intracellular dissociation barrier of cationic polymer/DNA…”
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Molecularly Precise Dendrimer-Drug Conjugates with Tunable Drug Release for Cancer Therapy by Zhou, Zhuxian, Ma, Xinpeng, Murphy, Caitlin J., Jin, Erlei, Sun, Qihang, Shen, Youqing, Van Kirk, Edward A., Murdoch, William J.

“…The structural preciseness of dendrimers makes them perfect drug delivery carriers, particularly in the form of dendrimer–drug conjugates. Current…”
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Targeted Charge-Reversal Nanoparticles for Nuclear Drug Delivery by Xu, Peisheng, Van Kirk, Edward A., Zhan, Yihong, Murdoch, William J., Radosz, Maciej, Shen, Youqing

“…Reversing the charges: Targeted charge‐reversal nanoparticles (TCRNs) comprised of poly(ε‐caprolactone)‐block‐polyethyleneimine (PCL‐PEI), whose amine groups…”
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Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery by Shen, Youqing, Zhou, Zhuxian, Sui, Meihua, Tang, Jianbin, Xu, Peisheng, Van Kirk, Edward A, Murdoch, William J, Fan, Maohong, Radosz, Maciej

“…Polyamidoamine (PAMAM) dendrimers with primary amine termini have been extensively explored as drug and gene carriers owing to their unique properties, but…”
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Anticancer Efficacies of Cisplatin-Releasing pH-Responsive Nanoparticles by Xu, Peisheng, Van Kirk, Edward A, Murdoch, William J, Zhan, Yihong, Isaak, Dale D, Radosz, Maciej, Shen, Youqing

“…The objective of these investigations was to test the hypothesis that a rapid cytoplasmic release profile from nanoparticles would potentiate the anticancer…”
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Degradable Poly(β-amino ester) nanoparticles for cancer cytoplasmic drug delivery by Shen, Youqing, PhD, Tang, Huadong, PhD, Zhan, Yihong, BS, Van Kirk, Edward A., MS, Murdoch, William J., PhD

“…Abstract Fast cytoplasmic drug delivery can overcome cancer cells' drug resistance and thus have an enhanced therapeutic efficacy. Such a drug delivery regime…”
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Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery by Sun, Qihang, Ma, Xinpeng, Zhang, Bo, Zhou, Zhuxian, Jin, Erlei, Shen, Youqing, Van Kirk, Edward A, Murdoch, William J, Radosz, Maciej, Sun, Weilin

“…An inherent dilemma in the use of nanomedicines for cancer drug delivery is their limited penetration into tumors due to their large size. We have demonstrated…”
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Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery by Zhou, Zhuxian, Ma, Xinpeng, Jin, Erlei, Tang, Jianbin, Sui, Meihua, Shen, Youqing, Van Kirk, Edward A, Murdoch, William J, Radosz, Maciej

“…Abstract Elongated micelles have many desirable characteristics for cancer-drug delivery, but they are difficult to obtain since amphiphilic polymers form such…”
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Charge-Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery by Zhou, Zhuxian, Shen, Youqing, Tang, Jianbin, Fan, Maohong, Van Kirk, Edward A, Murdoch, William J, Radosz, Maciej

“…DNA‐toxin anticancer drugs target nuclear DNA or its associated enzymes to elicit their pharmaceutical effects, but cancer cells have not only…”
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Curcumin polymers as anticancer conjugates by Tang, Huadong, Murphy, Caitlin J, Zhang, Bo, Shen, Youqing, Van Kirk, Edward A, Murdoch, William J, Radosz, Maciej

“…Abstract Curcumin has been shown highly cytotoxic towards various cancer cell lines, but its water-insolubility and instability make its bioavailability…”
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Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes by Xu, Peisheng, Li, Shi-Yan, Li, Qun, Ren, Jun, Van Kirk, Edward A., Murdoch, William J., Radosz, Maciej, Shen, Youqing

“…Viral‐mediated gene delivery has been explored for the treatment and protection of cardiomyocytes, but so far there is only one report using cationic polymer…”
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Luteal Dysfunction in Ewes Induced to Ovulate Early in the Follicular Phase by Murdoch, William J., Van Kirk, Edward A.

“…Abstract The purpose of this investigation was to determine whether the timing of ovulation induction during the follicular phase is a determinant of…”
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Reproductive effects of a pegylated curcumin by Murphy, Caitlin J., Tang, Huadong, Van Kirk, Edward A., Shen, Youqing, Murdoch, William J.

“…► A water-soluble conjugate of curcumin and polyethylene glycol with antitumor properties was constructed. ► Parenteral administration of pegylated curcumin…”
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Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery by Shen, Youqing, Zhan, Yihong, Tang, Jianbin, Xu, Peisheng, Johnson, Patrick A, Radosz, Maciej, Van Kirk, Edward A, Murdoch, William J

“…Polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release, slow cellular uptake, and…”
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Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells by McDonnel, Anna C, Van Kirk, Edward A, Isaak, Dale D, Murdoch, William J

“…The lethality of common (surface) epithelial ovarian cancer is contingent on its metastatic capacity. Dissemination of the neoplasia throughout the abdominal…”
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Ovarian responses to undernutrition in pregnant ewes, USA by Murdoch, William J, Van Kirk, Edward A, Vonnahme, Kimberly A, Ford, Stephen P

“…In most mammals oogonia proliferate by mitosis and begin meiotic development during fetal life. Previous studies indicated that there is a delay in the…”
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Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy by Xu, Peisheng, Van Kirk, Edward A., Li, Shiyan, Murdoch, William J., Ren, Jun, Hussain, Muhammad Delwar, Radosz, Maciej, Shen, Youqing

“…Cisplatin is a potent anticancer drug with low solubility in water. A new type of highly stable polymer micelles, namely core-surface-crosslinked nanoparticles…”
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Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts by Murdoch, William J, Van Kirk, Edward A, Isaak, Dale D, Shen, Youqing

“…Abstract Objectives The underlying premise of these investigations was that the lipophilic hormone progesterone, which partitions into and (at relatively high…”
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DNA damages in ovarian surface epithelial cells of ovulatory hens by Murdoch, William J, Van Kirk, Edward A, Alexander, Brenda M

“…A cause-effect relationship between ovulation and common (surface) epithelial ovarian cancer has been suspected for many years. The ovarian surface epithelium…”
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