Search Results - "Van Kempen, Leon C"

Identification of Six Loci Associated With Pelvic Organ Prolapse Using Genome-Wide Association Analysis by Allen-Brady, Kristina, Cannon-Albright, Lisa, Farnham, James M., Teerlink, Craig, Vierhout, Mark E., van Kempen, Léon C. L., Kluivers, Kirsten B., Norton, Peggy A.

“…There is evidence that both environmental and genetic factors contribute to pelvic organ prolapse. We conducted a genome-wide association study to investigate…”
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The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene by van Kempen, Léon C L, Redpath, Margaret, Elchebly, Mounib, Klein, Kathleen Oros, Papadakis, Andreas I, Wilmott, James S, Scolyer, Richard A, Edqvist, Per-Henrik, Pontén, Fredrik, Schadendorf, Dirk, van Rijk, Anke F, Michiels, Stefan, Dumay, Anne, Helbling-Leclerc, Anne, Dessen, Philippe, Wouters, Jasper, Stass, Marguerite, Greenwood, Celia M T, Ghanem, Ghanem E, van den Oord, Joost, Feunteun, Jean, Spatz, Alan

“…Male gender is independently and significantly associated with poor prognosis in melanoma of all clinical stages. The biological underpinnings of this sex…”
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Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research by Ehrlich, Aliza T., Maroteaux, Grégoire, Robe, Anne, Venteo, Lydie, Nasseef, Md. Taufiq, van Kempen, Leon C., Mechawar, Naguib, Turecki, Gustavo, Darcq, Emmanuel, Kieffer, Brigitte L.

“…Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug discovery. In the brain, oGPCRs are generally expressed at low abundance and…”
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GLI2-Mediated Melanoma Invasion and Metastasis by Alexaki, Vasileia-Ismini, Javelaud, Delphine, Van Kempen, Leon C. L., Mohammad, Khalid S., Dennler, Sylviane, Luciani, Flavie, Hoek, Keith S., Juàrez, Patricia, Goydos, James S., Fournier, Pierrick J., Sibon, Claire, Bertolotto, Corine, Verrecchia, Franck, Saule, Simon, Delmas, Veronique, Ballotti, Robert, Larue, Lionel, Saiag, Philippe, Guise, Theresa A., Mauviel, Alain

“…Background The transforming growth factor-β (TGF-β) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in…”
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Intratumoral rhIL‐12 administration in head and neck squamous cell carcinoma patients induces B cell activation by van Herpen, Carla M.L., van der Voort, Robbert, van der Laak, Jeroen A.W.M., Klasen, Ina S., de Graaf, Aniek O., van Kempen, Léon C.L., de Vries, I. Jolanda M., Boer, Tjitske Duiveman‐de, Dolstra, Harry, Torensma, Ruurd, van Krieken, Johan H., Adema, Gosse J., De Mulder, Pieter H.M.

“…The objectives of this study were to investigate the effects of intratumorally (i.t.) administered recombinant human interleukin‐12 (rhIL‐12) on the…”
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Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma by van Kempen, Léon C.L.T., Rijntjes, Jos, Mamor‐Cornelissen, Ine, Vincent‐Naulleau, Silvia, Gerritsen, Marie‐Jeanne P., Ruiter, Dirk J., van Dijk, Marcory C.R.F., Geffrotin, Claudine, van Muijen, Goos N.P.

“…Tumors are complex tissues composed of neoplastic cells, soluble and insoluble matrix components and stromal cells. Here we report that in melanoma, turn‐over…”
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Modulation of Activated Leukocyte Cell Adhesion Molecule–Mediated Invasion Triggers an Innate Immune Gene Response in Melanoma by van Kilsdonk, Jeroen W.J., Takahashi, Nozomi, Weidle, Ulrich, Burtscher, Helmut, Jarry, Jonathan, Daha, Mohamed R., Swart, Guido W.M., van Kempen, Léon C.L.T.

“…Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a progression marker of a variety of cancers, including melanoma, and is a marker for mesenchymal…”
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Multicenter Evaluation of the Idylla GeneFusion in Non–Small-Cell Lung Cancer by Depoilly, Thomas, Garinet, Simon, van Kempen, Léon C., Schuuring, Ed, Clavé, Sergi, Bellosillo, Beatriz, Ercolani, Cristiana, Buglioni, Simonetta, Siemanowski, Janna, Merkelbach-Bruse, Sabine, Tischler, Verena, Demes, Melanie-Christin, Paridaens, Henry, Sibille, Catherine, de Montpreville, Vincent Thomas, Rouleau, Etienne, Bartczak, Artur, Pasieka-Lis, Monika, Teo, Ryan Yee Wei, Chuah, Khoon Leong, Barbosa, Marta, Quintana, Carlos, Biscuola, Michele, Delgado-Garcia, Mercedes, Vacirca, Davide, Rappa, Alessandra, Cashmore, Matthew, Smith, Matthew, Jasionowicz, Piotr, Meeney, Adam, Desmeules, Patrice, Terris, Benoit, Mansuet-Lupo, Audrey

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A systematic review of clinical studies on hereditary factors in pelvic organ prolapse by Lince, Sabrina L., van Kempen, Leon C., Vierhout, Mark E., Kluivers, Kirsten B.

“…Introduction and hypothesis There is growing evidence that pelvic organ prolapse (POP) is at least partly caused by underlying hereditary risk factors. The aim…”
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Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material by Steeghs, Elisabeth M P, Kroeze, Leonie I, Tops, Bastiaan B J, van Kempen, Leon C, Ter Elst, Arja, Kastner-van Raaij, Annemiek W M, Hendriks-Cornelissen, Sandra J B, Hermsen, Mandy J W, Jansen, Erik A M, Nederlof, Petra M, Schuuring, Ed, Ligtenberg, Marjolijn J L, Eijkelenboom, Astrid

“…Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for…”
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Keratin 19: a key role player in the invasion of human hepatocellular carcinomas by Govaere, Olivier, Komuta, Mina, Berkers, Johannes, Spee, Bart, Janssen, Carl, de Luca, Francesca, Katoonizadeh, Aezam, Wouters, Jasper, van Kempen, Léon C, Durnez, Anne, Verslype, Chris, De Kock, Joery, Rogiers, Vera, van Grunsven, Leo A, Topal, Baki, Pirenne, Jacques, Vankelecom, Hugo, Nevens, Frederik, van den Oord, Joost, Pinzani, Massimo, Roskams, Tania

“…Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying…”
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Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age by van de Nieuwenhof, Hedwig P, Massuger, Leon F.A.G, van der Avoort, Irene A.M, Bekkers, Ruud L.M, Casparie, Mariel, Abma, Wim, van Kempen, Léon C.L.T, de Hullu, Joanne A

“…Abstract Objective The purpose of the present study is to investigate the trends in incidence of both usual (u) and differentiated (d) vulvar intraepithelial…”
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ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants by de la Fouchardiere, Arnaud, Blokx, Willeke, van Kempen, Léon C., Luzar, Boštjan, Piperno-Neumann, Sophie, Puig, Susana, Alos, Llucia, Calonje, Eduardo, Massi, Daniela

“…The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep…”
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Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation by Lutz, Pierre-Eric, Chay, Marc-Aurèle, Pacis, Alain, Chen, Gary G., Aouabed, Zahia, Maffioletti, Elisabetta, Théroux, Jean-François, Grenier, Jean-Christophe, Yang, Jennie, Aguirre, Maria, Ernst, Carl, Redensek, Adriana, van Kempen, Léon C., Yalcin, Ipek, Kwan, Tony, Mechawar, Naguib, Pastinen, Tomi, Turecki, Gustavo

“…Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifetime risk by epigenetically regulating the genome. Here,…”
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Radiogenomic Models Using Machine Learning Techniques to Predict EGFR Mutations in Non-Small Cell Lung Cancer by Nair, Jay Kumar Raghavan, Saeed, Umar Abid, McDougall, Connor C., Sabri, Ali, Kovacina, Bojan, Raidu, B. V. S., Khokhar, Riaz Ahmed, Probst, Stephan, Hirsh, Vera, Chankowsky, Jeffrey, Van Kempen, Léon C., Taylor, Jana

“…Background: The purpose of this study was to build radiogenomics models from texture signatures derived from computed tomography (CT) and 18F-FDG PET-CT (FDG…”
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The Etiologic Role of HPV in Vulvar Squamous Cell Carcinoma Fine Tuned by VAN DE NIEUWENHOF, Hedwig P, VAN KEMPEN, Léon C. L. T, DE HULLU, Joanne A, BEKKERS, Ruud L. M, BULTEN, Johan, MELCHERS, Willem J. G, MASSUGER, Leon F. A. G

“…Purpose: High-risk human papilloma virus (HPV) plays a role in the development of a subset of vulvar squamous cell carcinomas. Uncertainty exists about the…”
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Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients by Leest, Paul van der, Janning, Melanie, Rifaela, Naomi, Azpurua, Maria L. Aguirre, Kropidlowski, Jolanthe, Loges, Sonja, Lozano, Nicolas, Sartori, Alexander, Irwin, Darryl, Lamy, Pierre-Jean, Hiltermann, T. Jeroen N, Groen, Harry J. M, Pantel, Klaus, Kempen, Léon C. van, Wikman, Harriet, Schuuring, Ed

“…Analysis of circulating tumor DNA (ctDNA) is a potential minimally invasive molecular tool to guide treatment decision-making and disease monitoring. A…”
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Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors by Leest, Paul, Hiddinga, Birgitta, Miedema, Anneke, Aguirre Azpurua, Maria L., Rifaela, Naomi, Elst, Arja, Timens, Wim, Groen, Harry J. M., Kempen, Léon C., Hiltermann, T. Jeroen N., Schuuring, Ed

“…Immunotherapy for metastasized non‐small‐cell lung cancer (NSCLC) can show long‐lasting clinical responses. Selection of patients based on programmed…”
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CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2: Characterizing CD4+ T cells in Hodgkin lymphoma by Veldman, Johanna, Rodrigues Plaça, Jessica, Chong, Lauren, Terpstra, Miente Martijn, Mastik, Mirjam, van Kempen, Léon C., Kok, Klaas, Aoki, Tomohiro, Steidl, Christian, van den Berg, Anke, Visser, Lydia, Diepstra, Arjan

“…In classical Hodgkin lymphoma (cHL), the highly abundant CD4+ T cells in the vicinity of tumor cells are considered essential for tumor cell survival, but are…”
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Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma by van de Nieuwenhof, Hedwig P, Bulten, Johan, Hollema, Harrie, Dommerholt, Rianne G, Massuger, Leon F A G, van der Zee, Ate G J, de Hullu, Joanne A, van Kempen, Leon C L T

“…Lichen sclerosus is considered to be the precursor lesion of vulvar squamous cell carcinoma, of which only 2–5% progress to squamous cell carcinoma…”
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