Search Results - "Van Kanegan, Michael J"

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models by Quinti, Luisa, Casale, Malcolm, Moniot, Sébastien, Pais, Teresa F, Van Kanegan, Michael J, Kaltenbach, Linda S, Pallos, Judit, Lim, Ryan G, Naidu, Sharadha Dayalan, Runne, Heike, Meisel, Lisa, Rauf, Nazifa Abdul, Leyfer, Dmitriy, Maxwell, Michele M, Saiah, Eddine, Landers, John E, Luthi-Carter, Ruth, Abagyan, Ruben, Dinkova-Kostova, Albena T, Steegborn, Clemens, Marsh, J Lawrence, Lo, Donald C, Thompson, Leslie M, Kazantsev, Aleksey G

“…There are currently no disease-modifying therapies for the neurodegenerative disorder Huntington's disease (HD). This study identified novel…”
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Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A by Christensen, Dale J, Ohkubo, Nobutaka, Oddo, Jessica, Van Kanegan, Michael J, Neil, Jessica, Li, Fengqiao, Colton, Carol A, Vitek, Michael P

“…The molecular mechanism by which apolipoprotein E (apoE) suppresses inflammatory cytokine and NO production is unknown. Using an affinity purification…”
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BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin by Van Kanegan, Michael J, He, Dong Ning, Dunn, Denise E, Yang, Peiying, Newman, Robert A, West, Anne E, Lo, Donald C

“…We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro…”
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Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke by Van Kanegan, Michael J., Dunn, Denise E., Kaltenbach, Linda S., Shah, Bijal, He, Dong Ning, McCoy, Daniel D., Yang, Peiying, Peng, Jiangnan, Shen, Li, Du, Lin, Cichewicz, Robert H., Newman, Robert A., Lo, Donald C.

“…We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO 2 extract of Nerium oleander , in…”
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Distinct Protein Phosphatase 2A Heterotrimers Modulate Growth Factor Signaling to Extracellular Signal-regulated Kinases and Akt by Van Kanegan, Michael J., Adams, Deanna G., Wadzinski, Brian E., Strack, Stefan

“…A key regulator of many kinase cascades, heterotrimeric protein serine/threonine phosphatase 2A (PP2A), is composed of catalytic (C), scaffold (A), and…”
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Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells by West, Michael D, Chang, Ching-Fang, Larocca, Dana, Li, Jie, Jiang, Jianjie, Sim, Pamela, Labat, Ivan, Chapman, Karen B, Wong, Kari E, Nicoll, James, Van Kanegan, Michael J, de Grey, Aubrey D N J, Nasonkin, Igor O, Stahl, Andreas, Sternberg, Hal

“…The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research…”
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Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells by Filonov, Daria, Tice, Raymond, Luo, Ruiyan, Grotegut, Chad, Van Kanegan, Michael J, Ludlow, John W, Il'yasova, Dora, Kinev, Alexander

“…There is increased interest in using high throughput assays to characterize human population variability in response to toxicants and drugs. Utilizing primary…”
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PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis by Dickey, Audrey S, Sanchez, Dafne N, Arreola, Martin, Sampat, Kunal R, Fan, Weiwei, Arbez, Nicolas, Akimov, Sergey, Van Kanegan, Michael J, Ohnishi, Kohta, Gilmore-Hall, Stephen K, Flores, April L, Nguyen, Janice M, Lomas, Nicole, Hsu, Cynthia L, Lo, Donald C, Ross, Christopher A, Masliah, Eliezer, Evans, Ronald M, La Spada, Albert R

“…Neurons must maintain protein and mitochondrial quality control for optimal function, an energetically expensive process. The peroxisome proliferator-activated…”
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The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation by Van Kanegan, Michael J, Strack, Stefan

“…Nerve growth factor (NGF) is critical for the differentiation and maintenance of neurons in the peripheral and central nervous system. Sustained…”
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Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons by Schnizler, Katrin, Shutov, Leonid P, Van Kanegan, Michael J, Merrill, Michelle A, Nichols, Blake, McKnight, G. Stanley, Strack, Stefan, Hell, Johannes W, Usachev, Yuriy M

“…Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key mechanisms mediating the hyperalgesic effects of inflammatory mediators,…”
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The Protein Phosphatase 2A Regulatory Subunits B′β and B′δ Mediate Sustained TrkA Neurotrophin Receptor Autophosphorylation and Neuronal Differentiation by Van Kanegan, Michael J., Strack, Stefan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients by Quinti, Luisa, Naidu, Sharadha Dayalan, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., Kazantsev, Aleksey G.

“…The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of…”
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Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E 2 in Mouse Sensory Neurons by Schnizler, Katrin, Shutov, Leonid P., Van Kanegan, Michael J., Merrill, Michelle A., Nichols, Blake, McKnight, G. Stanley, Strack, Stefan, Hell, Johannes W., Usachev, Yuriy M.

“…Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key mechanisms mediating the hyperalgesic effects of inflammatory mediators,…”
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The Protein Phosphatase 2A Regulatory Subunits B'? and B' Mediate Sustained TrkA Neurotrophin Receptor Autophosphorylation and Neuronal Differentiation by Van Kanegan, Michael J, Strack, Stefan

“…Nerve growth factor (NGF) is critical for the differentiation and maintenance of neurons in the peripheral and central nervous system. Sustained…”
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Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E sub(2) in Mouse Sensory Neurons by Schnizler, Katrin, Shutov, Leonid P, Van Kanegan, Michael J, Merrill, Michelle A, Nichols, Blake, McKnight, GStanley, Strack, Stefan, Hell, Johannes W, Usachev, Yuriy M

“…Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key mechanisms mediating the hyperalgesic effects of inflammatory mediators,…”
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Regulation of nerve growth factor signaling by protein phosphatase 2A by Van Kanegan, Michael J

“…The goal of this dissertation research is to determine novel regulatory mechanisms of neurotrophin signaling mediated by protein phosphatase 2A (PP2A). PP2A is…”
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