Search Results - "Van Hooser, Aaron A."

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A by Van Hooser, A A, Ouspenski, I I, Gregson, H C, Starr, D A, Yen, T J, Goldberg, M L, Yokomori, K, Earnshaw, W C, Sullivan, K F, Brinkley, B R

“…The mechanisms that specify precisely where mammalian kinetochores form within arrays of centromeric heterochromatin remain largely unknown. Localization of…”
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The mammalian centromere: structural domains and the attenuation of chromatin modeling by Van Hooser, Aaron A., Mancini, Michael A., Allis, C. David, Sullivan, Kevin F., Brinkley, B. R.

“…ABSTRACTThe centromere‐kinetochore complex can be divided into distinct domains based on structure and function. Previous work has used CREST auto‐antibodies…”
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Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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perichromosomal layer by Van Hooser, Aaron A, Yuh, Patrick, Heald, Rebecca

“…In addition to genetic information, mitotic chromosomes transmit essential components for nuclear assembly and function in a new cell cycle. A specialized…”
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Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy by Laifenfeld, Daphna, Drubin, David A, Catlett, Natalie L, Park, Jennifer S, Van Hooser, Aaron A, Frushour, Brian P, de Graaf, David, Fryburg, David A, Deehan, Renée

“…The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major…”
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Localization of human SMC1 protein at kinetochores by Gregson, Heather C, Van Hooser, Aaron A, Ball, Jr, Alexander R, Brinkley, B R, Yokomori, Kyoko

“…Proper cohesion of sister chromatids is prerequisite for correct segregation of chromosomes during cell division. The cohesin multiprotein complex, conserved…”
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Kinetochore function: The complications of becoming attached by Van Hooser, Aaron A, Heald, Rebecca

“…Kinetochores are specialized protein complexes assembled on centromeric DNA that connect to spindle microtubules and mediate proper chromosome segregation…”
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Relevance of histone acetylation and replication timing for deposition of centromeric histone CENP-A by Ouspenski, Ilia I, Van Hooser, Aaron A, Brinkley, B.R

“…A centromere-specific variant of histone H3, centromere protein A (CENP-A), is a critical determinant of centromeric chromatin, and its location on the…”
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Abstract 4132: Predictive classifiers for response to c-Met targeted therapies in lung and colon cancer by Drubin, David, Catlett, Natalie L., Park, Jennifer, Van Hooser, Aaron A., Frushour, Brian P., Kenney, Renee Deehan

“…Abstract A fundamental challenge in the development of cancer therapies is the co-development of companion biomarkers to select patients most likely to respond…”
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