Search Results - "Van Hooff, Johannes P."

Lower Variability in 24-Hour Exposure During Once-Daily Compared to Twice-Daily Tacrolimus Formulation in Kidney Transplantation by Stifft, Frank, Stolk, Leo M.L, Undre, Nasrullah, van Hooff, Johannes P, Christiaans, Maarten H.L

“…INTRODUCTIONTacrolimus has originally been registered as a twice-daily formulation (Prograf, Tac BID), although a once-daily formulation (Advagraf, Tac QD) is…”
Get full text

Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients by Stifft, Frank, Undre, Nasrullah, van Hooff, Johannes P, Christiaans, Maarten H L

“…The once-daily Tacrolimus formulation (Tac ONCE-DAILY) has to be taken on an empty stomach. This is inconvenient for patients and may hamper compliance. The…”
Get full text

Early Loss of Peritubular Capillaries after Kidney Transplantation by STEEGH, Floortje M. E. G, GELENS, Marielle A. C. J, NIEMAN, Fred H. M, VAN HOOFF, Johannes P, CLEUTJENS, Jack P. M, JAN VAN SUYLEN, Robert, DAEMEN, Mat J. A. P, VAN HEURN, Ernst L. W, CHRISTIAANS, Maarten H. L, PEUTZ-KOOTSTRA, Carine J

“…Inflammation, interstitial fibrosis (IF), and tubular atrophy (TA) precede chronic transplant dysfunction, which is a major cause of renal allograft loss…”
Get full text

Similarities in Skeletal Muscle Strength and Exercise Capacity Between Renal Transplant and Hemodialysis Patients by Van Den Ham, Eugénie C.H., Kooman, Jeroen P., Schols, Annemie M.W.J., Nieman, Fred H.M., Does, Joan D., Franssen, Frits M.E., Akkermans, Marco A., Janssen, Paul P., Van Hooff, Johannes P.

“…Exercise intolerance is common in hemodialysis (HD) and renal transplant (RTx) patients. Aim of the study was to assess to what extent exercise capacity and…”
Get full text

Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation by Stifft, Frank, Stolk, Leo M L, Undre, Nasrullah, van Hooff, Johannes P, Christiaans, Maarten H L

“…Tacrolimus has originally been registered as a twice-daily formulation (Prograf, Tac BID), although a once-daily formulation (Advagraf, Tac QD) is also…”
Get full text

Immunosuppressive Regimen and Interstitial Fibrosis and Tubules Atrophy at 12 Months Postrenal Transplant by Gelens, Mariëlle A C J, Steegh, Floor M E G, van Hooff, Johannes P, van Suylen, Robert Jan, Nieman, Frederikus H M, van Heurn, Lodewijk W E, Peutz-Kootstra, Carine J, Christiaans, Maarten H L

“…Chronic renal transplant dysfunction is histopathologically characterized by interstitial fibrosis and tubular atrophy. This study investigated the relative…”
Get full text

Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms by Op den Buijsch, Robert A.M., Christiaans, Maarten H.L., Stolk, Leo M.L., De Vries, Johan E., Cheung, Chi Yuen, Undre, Nas A., Van Hooff, Johannes P., Van Dieijen-Visser, Marja P., Bekers, Otto

“…Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range and its pharmacokinetic variability complicates its daily…”
Get full text

Influence of tacrolimus on glucose metabolism before and after renal transplantation : A prospective study by VAN DUIJNHOVEN, Elly M, BOOTS, Johannes M. M, CHRISTIAANS, Maarten H. L, WOLFFENBUTTEL, Bruce H. R, VAN HOOFF, Johannes P

“…Most studies concerning the influence of tacrolimus on glucose metabolism have been performed either in animals or after organ transplantation. These clinical…”
Get full text

Effect of closure of the arteriovenous fistula on left ventricular dimensions in renal transplant patients by van Duijnhoven, Elly C. M., Cheriex, Emile C. M., Tordoir, Jan H. M., Kooman, Jeroen P., van Hooff, Johannes P.

“…Background. Left ventricular hypertrophy is common in renal transplant patients. One of the factors that might contribute to this phenomenon is the persisting…”
Get full text

Impact of CYP3A5 Genetic Polymorphism on Intrapatient Variability of Tacrolimus Exposure in Chinese Kidney Transplant Recipients by Cheung, Chi Yuen, Chan, Koon Ming, Wong, Yuen Ting, Chak, Wai Leung, Bekers, Otto, van Hooff, Johannes P.

“…Although high tacrolimus (FK) intrapatient variability (IPV) was shown to be associated with poor graft outcome in kidney transplant recipients (KTRs), it is…”
Get full text

Influence of CYP3A5 Genetic Polymorphism on Long-Term Renal Function in Chinese Kidney Transplant Recipients Using Limited Sampling Strategy and Abbreviated Area Under the Curve for Tacrolimus Monitoring by Cheung, Chi Yuen, Chan, Koon Ming, Wong, Yuen Ting, Chak, Wai Leung, Bekers, Otto, van Hooff, Johannes P.

“…Introduction: Although the association between CYP3A5 gene polymorphism and tacrolimus dosing requirements was well established, the impact on how CYP3A5…”
Get full text

No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12 years tacrolimus exposure by Gelens, Mariëlle ACJ, van Hooff, Johannes P, Usvyat, Len, Christiaans, Maarten H

“…Aims Tacrolimus (Tac) inhibits insulin secretion in a Tac-trough blood level dependent way earlypost-transplant in renal transplant recipients (Rtx). It is…”
Get full text

Four-year experience with tacrolimus once-daily prolonged release in patients from phase II conversion and de novo kidney, liver, and heart studies by van Hooff, Johannes P., Alloway, Rita R., Trunečka, Pavel, Mourad, Michel

“…van Hooff JP, Alloway RR, Trunečka P, Mourad M. Four‐year experience with tacrolimus once‐daily prolonged release in patients from phase II conversion and de…”
Get full text

Three-year observational follow-up of a multicenter, randomized trial on tacrolimus-based therapy with withdrawal of steroids or mycophenolate mofetil after renal transplant by PASCUAL, Julio, VAN HOOFF, Johannes P, SALMELA, Kaija, LONG, Philippe, RIGOTTI, Paolo, BUDDE, Klemens

“…The challenge in renal transplantation is to improve long-term patient and graft survival without increasing early acute rejection by minimizing…”
Get full text

No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12years tacrolimus exposure by Gelens, Mariëlle A.C.J., van Hooff, Johannes P., Usvyat, Len, Christiaans, Maarten H.

“…Tacrolimus (Tac) inhibits insulin secretion in a Tac-trough blood level dependent way early post-transplant in renal transplant recipients (Rtx). It is unknown…”
Get full text

Clinical Relevance of Pretransplant Donor-Directed Antibodies Detected by Single Antigen Beads in Highly Sensitized Renal Transplant Patients by VAN DEN BERG-LOONEN, Ella M, BITTEN, Evy V. A, VOORTER, Christina E. M, VAN HEWN, L. W. Ernest, CLAAS, Frans H. J, VAN HOOF, Johannes P, CHRISTIAANS, Maarten H. L

“…Highly sensitized (HS) patients (>85% panel-reactive antibodies) have a lower chance of receiving a donor kidney. Within Eurotransplant the Acceptable Mismatch…”
Get full text

Minimization of Immunosuppressive Therapy After Renal Transplantation: Results of a Randomized Controlled Trial by Vanrenterghem, Yves, Van Hooff, Johannes P., Squifflet, Jean‐Paul, Salmela, Kaija, Rigotti, Paolo, Jindal, Rahul M., Pascual, Julio, Ekberg, Henrik, Sicilia, Luis Sanchez, Boletis, John N., Grinyo, Josep M., Rodriguez, Manuel Arias

“…Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunosuppressant like tacrolimus or cyclosporine with adjunctive…”
Get full text

Effect of immunosuppressive agents on long-term survival of renal transplant recipients: Focus on the cardiovascular risk by BOOTS, Johannes M. M, CHRISTIAANS, Maarten H. L, VAN HOOFF, Johannes P

“…In the control of acute rejection, attention is being focused more and more on the long-term adverse effects of the immunosuppressive agents used. Since…”
Get full text

Tacrolimus and posttransplant diabetes mellitus in renal transplantation by VAN HOOFF, Johannes P, CHRISTIAANS, Maarten H. L, VAN DUIJNHOVEN, Elly M

“…The most prominent side effect of tacrolimus is the induction of posttransplant diabetes mellitus (PTDM). In this review, the authors discuss the incidence,…”
Get full text

Evaluating mechanisms of post-transplant diabetes mellitus by van Hooff, Johannes P., Christiaans, Maarten H. L., van Duijnhoven, Elly M.

“…Post-transplant diabetes mellitus (PTDM) is a frequent complication in renal transplantation. While both tacrolimus and ciclosporin are known to be associated…”
Get full text