Incidental Coronary Artery Calcification Seen on Low-Dose Computed Tomography Is a Risk Factor for Obstructive Coronary Artery Disease in Patients Undergoing Liver Transplant

Incidental arterial calcification (Ca) on low-dose computed tomography (CT) prior to liver transplant (LT) may help identify those at risk for obstructive coronary artery disease (CAD). A single-center retrospective study of 358 consecutive patients who had undergone LT was performed. Of the 296 pat...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 50; no. 10; pp. 3487 - 3495
Main Authors:	Othman, T., Tun, H., Bainiwal, J.S., Andersen, E.S., Dharmavaram, N.L., Schwartzman, W.S., Baffo, A.N., Butera, B.C., Phuong, N.S., Xu, P.Z., Yasmeh, B., Gertsvolf, N.A., Yoon, A.J., Shavelle, D.M., Garg, P.K., Van Herle, H.M., Kahn, J.A., Kim, B.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2018
Subjects:	Aged Calcinosis - complications Calcinosis - diagnostic imaging Calcinosis - mortality Coronary Angiography - methods Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Female Humans Liver Transplantation - mortality Male Middle Aged Odds Ratio Retrospective Studies Risk Factors Tomography, X-Ray Computed - methods
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Summary:	Incidental arterial calcification (Ca) on low-dose computed tomography (CT) prior to liver transplant (LT) may help identify those at risk for obstructive coronary artery disease (CAD). A single-center retrospective study of 358 consecutive patients who had undergone LT was performed. Of the 296 patients who met inclusion criteria, 193 patients (65.2%) had CT Ca. Aortic Ca was seen in 116 (39.2%), coronary Ca in 141 (47.6%), and peripheral Ca in 8 patients (2.7%). Patients with coronary Ca were assigned ordinal coronary artery Ca scores and classified as mild, moderate, and severe. All-cause mortality was higher in patients with Ca in any location (14.5% vs 6.8%, P = .05). Of the patients who underwent coronary angiography, those with obstructive CAD were more likely to have aortic and coronary Ca than patients with nonobstructive or no CAD (85.7% vs 50.0%, P = .02 and 92.9% vs 37.9%, P = < .001, respectively). Severe coronary artery Ca scores were more frequent in patients with obstructive CAD (35.7% vs 0%, P < .001). Any severity coronary Ca had an odds ratio of 11.57 (95% CI, 1.61–244.92; P = .04) for obstructive CAD. In conclusion, incidental coronary Ca seen on low-dose CT is a risk factor for obstructive CAD in patients undergoing LT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2018.11.001